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Doctor insights on: Active Control In Clinical Trials

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How effective are mri's in showing active current demyelinating lesions in ms?

How effective are mri's in showing active current demyelinating lesions in ms?

Very effective: MRI is indeed "Gold standard", and helps us make decisions regarding diagnosis and changes in therapy. Note you state diagnosis of MS, but do NOT find any disease modifying drug listed. Prednisone is fine for relapse, and IVIG might be used if you were pregnant, but neither helps control the disease chronically. Note fresh frozen plasma, and this too, has no role in MS therapy. ...Read more

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Dr. Gary Sandler
2 doctors shared insights

Clinical Trial (Definition)

Science is a method using simplicity, theories and then tests to see if the theory works; always. Clinical trials involve comparing one approach/choice/treatment option with another & checking outcomes. Key methodology is double blind & ideally cross-over design with outcome measures to be used determined in advance. Double blind: neither participants or people near them know ...Read more


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Is there any corrlational research on low birth weight and later life diseases states.?

Is there any corrlational research on low birth weight and later life diseases states.?

Depends: Premature infants are LBW (low birth weight). So are some other gestational age infants that did not achieve full growth potential. Depending on the severity of growth restriction (called SGA-small for gestational age), they may have no, small, or moderate learning disabilities. Depending on the severity of premature complications-they may have psychomotor, cognitive, or learning disabilities. ...Read more

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In drug trials, is a placebo used to avoid harming some of the volunteers?

In drug trials, is a placebo used to avoid harming some of the volunteers?

A placebo: Is a preparation made as much as possible just like the drug under test except missing the ingredient being tested. Ideally neither the patient nor the doctor knows which each patient is given. After a period of time, the results are evaluated to see if the drug group got a significant improvement over the control (placebo) group. Hopefully neither group is harmed. ...Read more

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Do children and adolescents have differential response rates in placebo-controlled trials of fluoxetine?

Do children and adolescents have differential response rates in placebo-controlled trials of fluoxetine?

Don't know: I don't know about placebo controlled trials and the response rates. I know that in most cases of children and teens that i treat with fluoxetine, there is dramatic improvement in 1-2 weeks. ...Read more

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What are the most important clinical trials currently being done in cardiology?

What are the most important clinical trials currently being done in cardiology?

Clinical trials: http://cardiologytrials.org/ this is a decent start but your cardiologist will be able to provide you with more resources. ...Read more

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Medical/Surgical Oncology: Have you heard anything promising about the use of Keytruda in pancreatic cancer remission that are in clinical trials?

Medical/Surgical Oncology: Have you heard anything promising about the use of Keytruda in pancreatic cancer remission that are in clinical trials?

Keytruda: This is a relatively new product and I strongly suggest you go online and read the several articles about Keytruga. If you can't do that online please go to nearest library and they should be able to help you. ...Read more

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Cancer: Is Keytruda, as a cancer immunotherapy, only currently available in a clinical trial?

Cancer: Is Keytruda, as a cancer immunotherapy, only currently available in a clinical trial?

Keytruda: Is available on the market for some cancer types of skin and lungs. May be it is still in trials for other forms of cancers. Ask your oncologist about the protocols meant for yourself or whom you're asking on his/her behalf, best wishes ...Read more

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Is there any research or study being conducted in the us on ketamine to relieve major depression, as in the recently published uk study at oxford heal?

Is there any research or study being conducted in the us on ketamine to relieve major depression, as in the recently published uk study at oxford heal?

Yes,several.: Several. You obviously read the research at oxford health nhs, one at houston's baylor college of medicine, new york mt. Sinai school of medicine and are the ones that immediately comes to mind. Although it is promising, the long term effects are yet unknown so more research is needed. ...Read more

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Are there any studies that demonstrates the efficacy of a gluten free diet for autoimmune diseases?

Are  there any studies that demonstrates the efficacy of a gluten free diet for autoimmune diseases?

No reason why: Gluten intolerance is considered an autoimmune disease affecting a small but significant number of individuals. If you are not gluten intolerance, avoiding it would make no difference on other diseases whether autoimmune or not. However you will likely be less inclined to gain weight since so many great desserts contain gluten. No evidence that gluten issue leads to other autoimmune disorders. ...Read more

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Please help? Is the drug rivaroxaban still under phase III clinical trials?

Please help? Is the drug rivaroxaban still under phase III clinical trials?

Available: As far as i know it is now available for treatment of nonvalvular afib, treatment and post-event prophylaxis for dvt/pe. ...Read more

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Is there no research evidence that common antibiotics lower birth control pill effectiveness? Drug-related diarrhea would lower effectiveness, right?

Is there no research evidence that common antibiotics lower birth control pill effectiveness? Drug-related diarrhea would lower effectiveness, right?

Plenty of research: There is a great deal of research on the effects of antibiotics on oral contraceptive reliability. Not all of it is consistent, though. It is clear that rifampin and griseofulvin are two antibiotics that definitely decrease the reliability of OC's. With other antibiotics, the evidence is not so clear. It is prudent to discuss this with your doctor when you're prescribed antibiotics. Good luck. ...Read more

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Are there any clinical trials using radiation therapy for hiv?

Are there any clinical trials using radiation therapy for hiv?

I don't think so.: Radiation is more standardly used to treat cancer and not illness such as hiv. Radiation has been used to treat kaposi's sarcoma which can be seen in HIV patients. Hiv medications are also being tested in combination with radiation to see if they make radiation treatment more effective. Also, radiation is a local treatment and HIV is a systemic problem so it doesn't make much sense to use. ...Read more

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Are there any therapies on the horizon to prevent the reoccurrence of chromophobe renal cancer? Any clinical trails currently taking place?

Advances in chemo: Chromophobe renal cancer accounts 5% of renal cancers, early detection and treatment has excellent prognosis. If there is over expression of cd 117 on cell membrane , kinase inhibitors like imatinib, disratinib, and nilotinib are very effective. Best thing is to see an oncologist, for more recent medications or trails. ...Read more

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Are there any statistical studies showing the effectiveness of heat-based male contraception.?

Are there any statistical studies showing the effectiveness of heat-based male contraception.?

Here is a summary: A brief summary can be found at: http://malecontraceptives.Org/methods/simple_heat.Php. ...Read more

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Are birth control pills for catamenial epilepsy contraindicated in case of family history of breast cancer and smoking? I am 41, have catamenial epilepsy, and it's been suggested that birth control pills could help. I tolerate aed's poorly, the side effec

Are birth control pills for catamenial epilepsy contraindicated in case of family history of breast cancer and smoking? I am 41, have catamenial epilepsy, and it's been suggested that birth control pills could help. I tolerate aed's poorly, the side effec

No: Birth control pills aren't contraindicate due to your family history of breast cancer. If you are still smoking, they may be contraindicated depending on your age. Be sure to ask your doctor about this. There is a higher risk of blood clots and stroke while on birth control pills. Be sure you understand the risks. It sounds like you might really benefit from them! ...Read more

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Are there any research papers on the ketogenic diet and PMS?

Are there any research papers on the ketogenic diet and PMS?

A lit search start: I don't know of one, but here is a starting point through which you may find what you want. http://www.theketogenicdiet.org/ Ask questions there. Good luck in your hunting! ...Read more

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Over active thyroid/ or under active cam that effect sex life in females?

Over active thyroid/ or under active cam that effect sex life in females?

Yes: Changes in thyroid can affect the mood and energy level which can be a cause of decreased libido/sex drive in anyone. Hyperthyroidism causes anxiety, insomnia and muscle weakness, hypothyroidism causes depressed mood, fatigue and also weakness. ...Read more

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Are reports from those clinical trials reliable?

Are reports from those clinical trials reliable?

Great question.: This is a complicated subject that people spend their entire careers on - what makes a good study/clinical trial? It depends on many things: what type of study is done, funding source, if the results are clinically significant or just statistically sig, how is the data analyzed, etc. If there's a particular study you see in the news, your doctor might be able to help clarify the take home points. ...Read more