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Doctor insights on: Activase Clot Buster

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Does aspirin dissolve blood clots?

Does aspirin dissolve blood clots?

No: Aspirin is used to prevent the formation of blood clots through the inhibition of aggregation of cells (platelets) that are part of the clot. Once the clot is formed, Aspirin is not very effective in dissolving it. This is because the clot has material incorporated in it that does not respond to the action of aspirin. ...Read more

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Dr. Lynne Weixel
12 doctors shared insights

Alteplase (Definition)

Alteplase is a clot buster which is a kind of ...Read more


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Inner lining clot formation -> mural thrombi ->?

Inner lining clot formation -> mural thrombi ->?

Clot: Usually inside the lumen of an artery, can be dangerous due to propensity to embolize. ...Read more

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Can Plavix (clopidogrel) prevent a blood clot forming due to AF? Can't take anticoagulants.

Can Plavix (clopidogrel) prevent a blood clot forming due to AF? Can't take anticoagulants.

Plavix (clopidogrel) and afib: ACTIVE trial -Plavix (clopidogrel) +ASA(100) reduced vascular event ( stroke, MI, embolism) in AF with bleeding comparable to warfarin,but ACTIVE W trial noted warfarin was superior to ASA + Plavix (clopidogrel) in preventing vascular events. That said The AHA does not recommend adding Plavix (clopidogrel) to ASA. The first choice is warfarin followed by dabigitran, apixaban and rivaroxaban.ASA would be last. Talk to a cardiologist. ...Read more

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So Coumadin (warfarin) thins the blood to prevent new clots from forming --is there anything in Coumadin (warfarin) to actively dissolve clot that are already formed or are?

So Coumadin (warfarin) thins the blood to prevent new clots from forming --is there anything in Coumadin (warfarin) to actively dissolve clot that are already formed or are?

No: Coumadin (warfarin) keeps more clots from forming and thus facilitates the working of the body's clot breakdown system. Nothing in Coumadin (warfarin) actively breaks down clot...Only fibrinolytic agents like tpa do this and are given intraarterially or intravenously. ...Read more

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Can aspirin dissolve blood clots in the legs?

Can aspirin dissolve blood clots in the legs?

No: Aspirin can inhibit coagulation of blood in the legs, but once a clot forms it will not dissolve the clot. At that point "blood thinners" are the treatment. ...Read more

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Could blood thinners dissolve the blood vessels as well?

Could blood thinners dissolve the blood vessels as well?

No: The blood thinners really do not " thin" the blood they alter the cascade of chemical events that lead to platelet clot formation. So in reality the blood isn't thinner it just has a difficult time clotting. THese drugs do not dissolve the vessels. ...Read more

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Leg blood clot from sinus surgery?

Leg blood clot from sinus surgery?

Possible: A period of immobility and surgery can contribute to risk of a blood clot. Especially if surgery was more than an hour. Also if no sequential compression devices on legs during surgery. If curious, call your doc. ...Read more

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Can anticoagulants and antiplatelet work on an already formed thrombus?

Prevent: They prevent it from becoming larger and from loosening and ending up somewhere else. Follow advice of your prescribing physician. ...Read more

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Could vasodilators dislodge bloodclots?

Could vasodilators dislodge bloodclots?

Vasodilator a: That would be a very unlikely occurrence. ...Read more

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Blood thinners prevent the formation of new clots, to allow the bodies anti-clotting mechanisms to break down actual clot more effectively. Correct?

Close enough: So called blood thinner prevent formation of new clots, but do not accelerate the breakdown of existing clots. There are other medications for that, i.e.., thrombolytic medications. ...Read more

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Dose Coumadin (warfarin) help with blood clot i ling?

Dose Coumadin (warfarin) help with blood clot i ling?

Anticoagulant: Coumadin (warfarin) is an anticoagulant that works to block production of some of the building blocks used in blod clotting. It needs to be monitored regularly due to the fact that the levels can very in the body, affected by foods you eat, interactions with other medications, and your own metabolism. ...Read more

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Omega 3s for blood clot prevention?

Omega 3s for blood clot prevention?

Omega threes: These agents are not anticoagulants and can not be counted on for clot prevention. ...Read more

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Blood clot followed by hydroxycut, chance of new clot?

Blood clot followed by hydroxycut, chance of new clot?

See below: I would not take it if you had a problem before.Check with your md there are better ways to lose weight than this! see www.Weighstation.Net for help and free information! ...Read more

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Is anticoagulation effective in pregnancy? Wil it defenitely stop blood clotting?

Effective: Anticoagulation is effective however options are limited in pregnancy. Anticoagulation reduces risk of abnormal clotting in most, however does not eliminate the risk. ...Read more

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What happens when a blood clot blocks a vessel?

What happens when a blood clot blocks a vessel?

Depends: It depends if the vessel is an artery or a vein, size of the vessel, collateral circulation, associated illnesses, and if the clot gets infected. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex, if you have sex. ...Read more

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What is a difference between calcium channel blocker and clot buster?

What is a difference between calcium channel blocker and clot buster?

Apples vs. oranges: They are both cardiac medicines. They are however used for totally different reasons. Calcium blockers are most commonly used to treat high blood pressure. They may also be used to treat chest pain or to slow the heart. Clot busters are used to dissolve a clot in the arteries that supply blood to the heart itself and therefore to limit the amount of heart damaged by removing the blockage. ...Read more

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Any drugs out there to break up plaque in coronary arteries rather than all invasive stuff? Clot buster drugs but nothing for plaque?

Any drugs out there to break up plaque in coronary arteries rather than all invasive stuff? Clot buster drugs but nothing for plaque?

No.: The various kinds of plaque that build up in the arteries have been building up for years, in some cases even decades. There is no medicine that will undo the remodeling due to years or decades of high blood pressure, smoking, cholesterol, etc. The best strategy is to modify the modifiable risk factors (and hope you have good genes). ...Read more

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My husband is hospitalized for dvt. Should he ask for inferior vena cava filter even if he doesn't undergo tpa (alteplase) treatment? (unsure when clot formed.)

My husband is hospitalized for dvt. Should he ask for inferior vena cava filter even if he doesn't undergo tpa (alteplase) treatment? (unsure when clot formed.)

No: The indication for ivc filter placement in a patient with an acute DVT is usually related to a contraindication of the patient to be anticoagulated. If your husband can be anticoagulated then ther is no reason for him to have a filter. ...Read more

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Who should not use Alteplase injections?

Who should not use Alteplase injections?

Alteplase injections: CONTRAINDICATIONS: Active internal bleeding. Recent intracranial or intraspinal surgery or serious head trauma. Intracranial conditions that may increase the risk of bleeding. Bleeding diathesis. Current severe uncontrolled hypertension. Acute Ischemic Stroke • Current intracranial hemorrhage. Subarachnoid hemorrhage. Acute Myocardial Infarction.or Pulmonary Embolism recent stroke. See: ...Read more

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How effective are Alteplase injections for treating stroke?

FDA approved for AIS: AIS = acute ischemic stroke. Think FAST (http://goo.gl/I9dyo2) = Face droopy, Arms (or legs) weak, Speech difficult, Time to call 911. We have less than 3hrs after symptom onset. Check out http://www.drugs.com/cdi/alteplase.html & http://www.activase.com/iscstroke (yes, I know it's Big Pharma but it's informative, and no, I have no relation). ...Read more

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What is tpa, (alteplase) and why is it important in stroke?

What is tpa, (alteplase) and why is it important in stroke?

TPA (alteplase): Tpa (alteplase) or tissue plasminogen activator is a subtance that is used to break up clots that form in the body. It has been used to stop heart attacks, strokes or clots that form in the arms or legs. It has even been used to dissolve clots in the lungs with some success. ...Read more

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What % of ischemic MCA stroke patients benefit from tpa (alteplase)?

What % of ischemic MCA stroke patients benefit from tpa (alteplase)?

Depends: This is a complex question. It depends on what percent of is already showing signs of infarction (dead brain) rather than just ischemia (brain at risk).... When we see > 1/3 of territory abnormal on initial ct scan, it is a contraindication for tpa (alteplase). It also depends on how long the symptoms have been occurring. But to answer your question, theoretically all could potentially benefit. ...Read more

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What is the age limit for being given tpa (alteplase)?

What is the age limit for being given tpa (alteplase)?

Gradient: The older one gets, the greater the risk of intracerebral hemorrhage. Especially after age 75 risk escalates. Then this turns on risk-benefit estimation. ...Read more

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What is the age limit for being given tpa (alteplase)?

Used to be rigid: Used to be arbitrary age which i believe was 75 and now is individualized. ...Read more

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What should be monitored before administering the tpa (alteplase)?

What should be monitored before administering the tpa (alteplase)?

Complicated : You need to check it with your physician since it depends on many parameters , but generally speaking: head ct, blood pressure, age, time onset of stroke, coagulant estate and use of anticoagulation, history of previous stroke, bleeding and recent surgeries.... ...Read more

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Why don't stroke patients get tpa (alteplase) therapy?

Why don't stroke patients get tpa (alteplase) therapy?

They can: If having a stroke one can receive intravenous tpa (alteplase) up to 3 hours once symptoms begin and up to 4.5 hours in certain cases. After this intra. ...Read more

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Could you tell me what happens if a person who is not actually having a stroke is given tpa (alteplase)?

Increased bleed risk: Tissue plasminogen activator, or tpa, (alteplase) "dissolves" clots, so the main risk from it's administration is an increased risk of bleeding. One way to reduce the risk is to have strict rules on who it is administered to, based on many factors including time since symptoms began. Another is to administer it right where it is needed, near the location of the artery which contains the clot. ...Read more

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Docs, could a patient be given tpa (alteplase) when on antiplatelet therapy?

Yes: TPA (alteplase) is not contraindicated with people taking aspirin, NSAIDs or antiplatelet drugs (dipyridamole, ticlopidine, clopidogrel). TPA (alteplase) is a contraindicated in people on warfarin whose INR is greater than 1.7. Use of low molecular weight heparin in the past 24 hours is also a contraindication. ...Read more

Dr. Jeffrey Stevens
3 doctors shared insights

Activase (Definition)

Activase is a clot buster which is a kind of ...Read more


Dr. Brian Santin
73 doctors shared insights

Clot Buster (Definition)

Clot busters are a kind of ...Read more