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Doctor insights on: Activase Clot Buster

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Dr. Gary Sandler
12 doctors shared insights

Alteplase (Definition)

Alteplase is a clot buster which is a kind of ...Read more


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What is a difference between calcium channel blocker and clot buster?

What is a difference between calcium channel blocker and clot buster?

Apples vs. oranges: They are both cardiac medicines. They are however used for totally different reasons. Calcium blockers are most commonly used to treat high blood pressure. They may also be used to treat chest pain or to slow the heart. Clot busters are used to dissolve a clot in the arteries that supply blood to the heart itself and therefore to limit the amount of heart damaged by removing the blockage. ...Read more

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Any drugs out there to break up plaque in coronary arteries rather than all invasive stuff? Clot buster drugs but nothing for plaque?

Any drugs out there to break up plaque in coronary arteries rather than all invasive stuff? Clot buster drugs but nothing for plaque?

No.: The various kinds of plaque that build up in the arteries have been building up for years, in some cases even decades. There is no medicine that will undo the remodeling due to years or decades of high blood pressure, smoking, cholesterol, etc. The best strategy is to modify the modifiable risk factors (and hope you have good genes). ...Read more

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My husband is hospitalized for dvt. Should he ask for inferior vena cava filter even if he doesn't undergo tpa (alteplase) treatment? (unsure when clot formed.)

My husband is hospitalized for dvt. Should he ask for inferior vena cava filter even if he doesn't undergo tpa (alteplase) treatment? (unsure when clot formed.)

No: The indication for ivc filter placement in a patient with an acute DVT is usually related to a contraindication of the patient to be anticoagulated. If your husband can be anticoagulated then ther is no reason for him to have a filter. ...Read more

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Who should not use Alteplase injections?

Who should not use Alteplase injections?

Alteplase injections: CONTRAINDICATIONS: Active internal bleeding. Recent intracranial or intraspinal surgery or serious head trauma. Intracranial conditions that may increase the risk of bleeding. Bleeding diathesis. Current severe uncontrolled hypertension. Acute Ischemic Stroke • Current intracranial hemorrhage. Subarachnoid hemorrhage. Acute Myocardial Infarction.or Pulmonary Embolism recent stroke. See: ...Read more

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How effective are Alteplase injections for treating stroke?

FDA approved for AIS: AIS = acute ischemic stroke. Think FAST (http://goo.gl/I9dyo2) = Face droopy, Arms (or legs) weak, Speech difficult, Time to call 911. We have less than 3hrs after symptom onset. Check out http://www.drugs.com/cdi/alteplase.html & http://www.activase.com/iscstroke (yes, I know it's Big Pharma but it's informative, and no, I have no relation). ...Read more

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What is tpa, (alteplase) and why is it important in stroke?

What is tpa, (alteplase) and why is it important in stroke?

TPA (alteplase): Tpa (alteplase) or tissue plasminogen activator is a subtance that is used to break up clots that form in the body. It has been used to stop heart attacks, strokes or clots that form in the arms or legs. It has even been used to dissolve clots in the lungs with some success. ...Read more

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What % of ischemic MCA stroke patients benefit from tpa (alteplase)?

What % of ischemic MCA stroke patients benefit from tpa (alteplase)?

Depends: This is a complex question. It depends on what percent of is already showing signs of infarction (dead brain) rather than just ischemia (brain at risk).... When we see > 1/3 of territory abnormal on initial ct scan, it is a contraindication for tpa (alteplase). It also depends on how long the symptoms have been occurring. But to answer your question, theoretically all could potentially benefit. ...Read more

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What is the age limit for being given tpa (alteplase)?

What is the age limit for being given tpa (alteplase)?

Gradient: The older one gets, the greater the risk of intracerebral hemorrhage. Especially after age 75 risk escalates. Then this turns on risk-benefit estimation. ...Read more

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What is the age limit for being given tpa (alteplase)?

Used to be rigid: Used to be arbitrary age which i believe was 75 and now is individualized. ...Read more

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What should be monitored before administering the tpa (alteplase)?

What should be monitored before administering the tpa (alteplase)?

Complicated : You need to check it with your physician since it depends on many parameters , but generally speaking: head ct, blood pressure, age, time onset of stroke, coagulant estate and use of anticoagulation, history of previous stroke, bleeding and recent surgeries.... ...Read more

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Why don't stroke patients get tpa (alteplase) therapy?

Why don't stroke patients get tpa (alteplase) therapy?

They can: If having a stroke one can receive intravenous tpa (alteplase) up to 3 hours once symptoms begin and up to 4.5 hours in certain cases. After this intra. ...Read more

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Could you tell me what happens if a person who is not actually having a stroke is given tpa (alteplase)?

Increased bleed risk: Tissue plasminogen activator, or tpa, (alteplase) "dissolves" clots, so the main risk from it's administration is an increased risk of bleeding. One way to reduce the risk is to have strict rules on who it is administered to, based on many factors including time since symptoms began. Another is to administer it right where it is needed, near the location of the artery which contains the clot. ...Read more

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Docs, could a patient be given tpa (alteplase) when on antiplatelet therapy?

Yes: TPA (alteplase) is not contraindicated with people taking aspirin, NSAIDs or antiplatelet drugs (dipyridamole, ticlopidine, clopidogrel). TPA (alteplase) is a contraindicated in people on warfarin whose INR is greater than 1.7. Use of low molecular weight heparin in the past 24 hours is also a contraindication. ...Read more

Dr. Ana Adelstein
3 doctors shared insights

Activase (Definition)

Activase is a clot buster which is a kind of ...Read more


Dr. Brian Santin
71 doctors shared insights

Clot Buster (Definition)

Clot busters are a kind of ...Read more