Doctor insights on:
Activase Clot Buster
No: Aspirin is used to prevent the formation of blood clots through the inhibition of aggregation of cells (platelets) that are part of the clot. Once the clot is formed, Aspirin is not very effective in dissolving it. This is because the clot has material incorporated in it that does not respond to the action of aspirin. ...Read moreSee 1 more doctor answer
Plavix (clopidogrel) and afib: ACTIVE trial -Plavix (clopidogrel) +ASA(100) reduced vascular event ( stroke, MI, embolism) in AF with bleeding comparable to warfarin,but ACTIVE W trial noted warfarin was superior to ASA + Plavix (clopidogrel) in preventing vascular events. That said The AHA does not recommend adding Plavix (clopidogrel) to ASA. The first choice is warfarin followed by dabigitran, apixaban and rivaroxaban.ASA would be last. Talk to a cardiologist. ...Read more
So Coumadin (warfarin) thins the blood to prevent new clots from forming --is there anything in Coumadin (warfarin) to actively dissolve clot that are already formed or are?
No: Coumadin (warfarin) keeps more clots from forming and thus facilitates the working of the body's clot breakdown system. Nothing in Coumadin (warfarin) actively breaks down clot...Only fibrinolytic agents like tpa do this and are given intraarterially or intravenously. ...Read moreSee 1 more doctor answer
Could plavix (clopidogrel) thin out plugs in blood vessels besides thinning one's blood to prevent clotting?
No: It doesn't dissolve clots - it lowers the risk of new ones forming. ...Read more
Which one better between pradaxa abd Plasmin Capsule( anti-coagulant drugs from china ; Lubrokinase)?
Prevent: They prevent it from becoming larger and from loosening and ending up somewhere else. Follow advice of your prescribing physician. ...Read more
Blood thinners prevent the formation of new clots, to allow the bodies anti-clotting mechanisms to break down actual clot more effectively. Correct?
Close enough: So called blood thinner prevent formation of new clots, but do not accelerate the breakdown of existing clots. There are other medications for that, i.e.., thrombolytic medications. ...Read more
Anticoagulant: Coumadin (warfarin) is an anticoagulant that works to block production of some of the building blocks used in blod clotting. It needs to be monitored regularly due to the fact that the levels can very in the body, affected by foods you eat, interactions with other medications, and your own metabolism. ...Read moreSee 3 more doctor answers
Depends: It depends if the vessel is an artery or a vein, size of the vessel, collateral circulation, associated illnesses, and if the clot gets infected. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex, if you have sex. ...Read more
Apples vs. oranges: They are both cardiac medicines. They are however used for totally different reasons. Calcium blockers are most commonly used to treat high blood pressure. They may also be used to treat chest pain or to slow the heart. Clot busters are used to dissolve a clot in the arteries that supply blood to the heart itself and therefore to limit the amount of heart damaged by removing the blockage. ...Read moreSee 1 more doctor answer
Any drugs out there to break up plaque in coronary arteries rather than all invasive stuff? Clot buster drugs but nothing for plaque?
No.: The various kinds of plaque that build up in the arteries have been building up for years, in some cases even decades. There is no medicine that will undo the remodeling due to years or decades of high blood pressure, smoking, cholesterol, etc. The best strategy is to modify the modifiable risk factors (and hope you have good genes). ...Read moreSee 1 more doctor answer
My husband is hospitalized for dvt. Should he ask for inferior vena cava filter even if he doesn't undergo tpa (alteplase) treatment? (unsure when clot formed.)
Alteplase injections: CONTRAINDICATIONS: Active internal bleeding. Recent intracranial or intraspinal surgery or serious head trauma. Intracranial conditions that may increase the risk of bleeding. Bleeding diathesis. Current severe uncontrolled hypertension. Acute Ischemic Stroke • Current intracranial hemorrhage. Subarachnoid hemorrhage. Acute Myocardial Infarction.or Pulmonary Embolism recent stroke. See: ...Read more
FDA approved for AIS: AIS = acute ischemic stroke. Think FAST (http://goo.gl/I9dyo2) = Face droopy, Arms (or legs) weak, Speech difficult, Time to call 911. We have less than 3hrs after symptom onset. Check out http://www.drugs.com/cdi/alteplase.html & http://www.activase.com/iscstroke (yes, I know it's Big Pharma but it's informative, and no, I have no relation). ...Read more
Alteplase: Yes you do.Get a more detailed answer ›
TPA (alteplase): Tpa (alteplase) or tissue plasminogen activator is a subtance that is used to break up clots that form in the body. It has been used to stop heart attacks, strokes or clots that form in the arms or legs. It has even been used to dissolve clots in the lungs with some success. ...Read moreSee 2 more doctor answers
Depends: This is a complex question. It depends on what percent of is already showing signs of infarction (dead brain) rather than just ischemia (brain at risk).... When we see > 1/3 of territory abnormal on initial ct scan, it is a contraindication for tpa (alteplase). It also depends on how long the symptoms have been occurring. But to answer your question, theoretically all could potentially benefit. ...Read more
Used to be rigid: Used to be arbitrary age which i believe was 75 and now is individualized. ...Read more
Could you tell me what happens if a person who is not actually having a stroke is given tpa (alteplase)?
Increased bleed risk: Tissue plasminogen activator, or tpa, (alteplase) "dissolves" clots, so the main risk from it's administration is an increased risk of bleeding. One way to reduce the risk is to have strict rules on who it is administered to, based on many factors including time since symptoms began. Another is to administer it right where it is needed, near the location of the artery which contains the clot. ...Read more
2 years ago all tests say I didn't have a stroke. Administered tpa (alteplase) and improved. Why did I respond to a drug for something tests say I didn't have?
No: NoGet a more detailed answer ›
Yes: TPA (alteplase) is not contraindicated with people taking aspirin, NSAIDs or antiplatelet drugs (dipyridamole, ticlopidine, clopidogrel). TPA (alteplase) is a contraindicated in people on warfarin whose INR is greater than 1.7. Use of low molecular weight heparin in the past 24 hours is also a contraindication. ...Read more