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Doctor insights on: Actin Antibody Lupus

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I have recurring flares of rashes, joint pain, muscle aches, debilitating fatigue, dizziness. I have photosensitity and one episode of my WBC at 2.0 years back. My ANA is 6:40. I'm on plaquenil. Why are all my other antibodies neg for lupus?

I have  recurring flares of  rashes, joint pain, muscle aches, debilitating fatigue, dizziness. I have photosensitity and one episode of my WBC at 2.0 years back.  My ANA is 6:40.  I'm on plaquenil. Why are all my other antibodies neg for lupus?

Maybe SLE maybe not.: Diagnosis of rheumatologic disease is generally based on symptoms with support from lab. Sounds like you have a rheumatologic disease and are being treated with a rheumatologic agent perhaps by a rheumatologist. They can explain your particular situation better, but suffice it to say tests are not always right and a single test does not generally make or break a diagnosis. ...Read more

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Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


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What does it mean to be positive for lupus antibodies?

What does it mean to be positive for lupus antibodies?

Not much: Having the antibody does not mean having the disease. You may be predisposed to it. Why did your doctor test for it in the first place? It all depends on what symptoms you have. A test by itself does not carry much meaning. ...Read more

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What are the pathways that enable misguided antibodies to attack in lupus patients?

What are the pathways that enable misguided antibodies to attack in lupus patients?

Complex but: The most likely explanation is a loss of immune regulation allowing your immune system to attack the tissues of your own body. The immune system is the pit bull in our body which tries to fend off outside invaders. When the owner can no longer control the pit bull, bad things are apt to happen. ...Read more

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I see my rheum in a couple weeks, but would having ssb antibodies cause problems even if lupus or other diseases weren't present?

I see my rheum in a couple weeks, but would having ssb antibodies cause problems even if lupus or other diseases weren't present?

See details: Positive ssb antibodies by themselves (when the ssa antibody is negative) have little clinical significance. They can be falsely positive. If the ANA and other tests for lupus are negative, i would disregard the ssb results. ...Read more

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The result of my SS-A/Ro Antibody, IgG, Serum is 1.6 and it says High. What could this mean? I have many lupus symptoms.

The result of my SS-A/Ro Antibody, IgG, Serum is 1.6 and it says High. What could this mean? I have many lupus symptoms.

Indeterminate: Anti-SSa/Ro autoantibodies are present in about 0.1-0.5 percent of people. There is an association with lupus but also biliary cirrhosis and Sjögren's syndrome. If you have this and other symptoms if lupus, as u say, it is possible you have lupus. You should consult with the doctor who ordered the blood work to determine for sure the next steps. Good luck! ...Read more

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How does anti DNA antibody come from lupus?

How does anti DNA antibody come from lupus?

Anti-DNA antibody: People with lupus develop abnormal substances in their blood called antibodies. These antibodies attack various organs of the body and cause the signs and symptoms of the disease. Anti-dna antibody is one such substance. The exact reason why people develop these antibodies is not known but there is often a genetic component (family history). ...Read more

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Rheumatoid arthiritis, + lupus antibodies, what does this mean?

Rheumatoid arthiritis, + lupus antibodies, what does this mean?

RA and lupus antibod: If the arthritis looks like RA and the RA antibodies are negative , the disease usually is less erosive and less distrctive to joints and can acrue more symptoms and signs of lupus. If the rheumatoid factor or ccp are positive, that makes the disease act more like ra. ...Read more

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I had a positive lupus antibody and was told I would need lifelong warfarin. Is this safe?

I had a positive lupus antibody and was told I would need lifelong warfarin. Is this safe?

Depends...: Patients who only have lupus anticoagulant or other anti-phospholipid antibodies should not be routinely anticoagulated with warfarin unless they have had a clot. Patients who have not had a clot are best off just taking a baby Aspirin daily. If you have not had a blood clot but you are being prescribed warfarin for just having antibodies, seek a 2nd opinion by another rheumatologist. ...Read more

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Do you have lupus if you have anticardiolipin antibodies? What else do you look for with this?

Not necessarily: Antiphospholipid antibodies can occur where there is no underlying disease or can be associated with lupus, rheumatoid arthritis and other disorders. ...Read more

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Since lupus is not an infection you can catch by exposure what does it mean to have lupus antibodies?

Autoimmune : Having the antibodies mean you are predisposed to develop it, it does not mean you have it. Lupus is an autoimmune disease. We don't treat a number or a test, we treat your symptoms and the blood tests help us in making the diagnosis. ...Read more

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I got a positive lupus antibody test in june and was told I would need lifelong warfarin. Is this accurate?

I got a positive lupus antibody test in june and was told I would need lifelong warfarin. Is this accurate?

Not necessarily: If all you had was one positive lupus antibody test, then that is not an indication for treatment with warfarin. To make a diagnosis of antiphospholipid syndrome requires multiple positive tests over time in addition to a clinical finding such as a blood clot or miscarriages. http://www.rheumatology.org/practice/clinical/patients/diseases_and_conditions/antiphospholipidsyndrome.asp. ...Read more

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Does highly elevated antinuclear antibody result always mean systemic lupus erythematosus?

Does highly elevated antinuclear antibody result always mean systemic lupus erythematosus?

Not always: Unfortunately, there is no single laboratory test that absolutely rules in or out systemic lupus erythematosis (sle). Although a highly positive antinuclear antigen (ANA) is common in sle, diagnosis is based on a careful history, physical exam and laboratory evaluation. ...Read more

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How likely is it for someone to get blood clots w/ positive antibodies ahpo in systemic lupus?

See below: It is estimated that 30 to 50% of lupus patients will have antiphospholipid antibodies---these manifest in variety ways such as migraines, miscarriages, strokes, and clots. Your odds are significantly highly for clots to occur if you smoke, physically inactive such as after surgery, or have glomerulonephritis. However; clots can occur randomly as well. ...Read more

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My dr said my blood work shows smith antibody, but rheumatologist don't think it's lupus, then what is it?

See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. One autoantibody is not sufficient to make a diagnosis of lupus. It would be prudent to follow the advice from the rheumatologist. ...Read more

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When they draw blood work to check for imflamation what could they be looking for ? Lupus ? Anti fospholipid antibody syndrome ?

Basic screen: If you are seeing your primary, you probably get a basic screen (sed rate, crp, as well as rh factor, and ana) to determine whether you have an inflammatory autoimmune process. We usually do not check antiphospholipid antibodies to assess inflammation. ...Read more

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What is a anti ssdna test? My doc did blood work because she thinks I have lupus or some other antibody. My ssdna was the only high test at 245.

Not helpful test: The ss or single stranded dna is a test no longer used for sle. It is sometimes seen in sle but from your description has no valuable meaning for you. It is ok for you to ignore it if all other tests are negative. This test is very nonspecific and has a high false positive rate. ...Read more

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