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Doctor insights on: Acth Stimulation Test Procedure

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Acth stimulation test results accurate?

Acth stimulation test results accurate?

Depends: I'm assuming no lab errors. If you get a very high cortisol spike after receiving the first dose of ACTH, you are reassured you do not have Addison's. No, or a very small spike, strongly suggests Addison's. In-between... that's why there are specialist endocrinologists. ...Read more

Acth Stimulation Test (Definition)

The acth stimulation test evaluate whether the adrenal gland can respond to stimulation from the pituitary gland by giving an artificial form of the pituitary hormone (acth) and measuring the adrenal gland hormone (cortisol) before and after the injection. Normally the cortisol level will rise after the injection; in most instances failure to do so indicates a problem ...Read more


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Acth stimulation test -- is that done in a lab?

Acth stimulation test -- is that done in a lab?

Yes and no.: Provocative acth is given iv. Serial blood measurements are made for detecting the rise in cortisol in the blood. These assays are done in a lab. ...Read more

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What is ab acth plasma stimulation test used for?

What is ab acth plasma stimulation test used for?

Adrenal insufficienc: If an individual's adrenals may not be making enough cortisone to live (symptoms include fatigue, abdominal pain, dizziness, nausia), this is tested. If someone has needed to be on repeated or prolonged Prednisone or quite high inhaled corticosteroids for a prolonged period, adrenal insufficiency is a possibility. Adrenal insufficiency may also be related to autoimmune causes. ...Read more

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Is acth stimulation test done at a normal lab that draws blood?

Is acth stimulation test done at a normal lab that draws blood?

ACTH test: The lab can draw blood for measurement of cortisol, but someone has to give the injection of acth (cortrosyn). The injection can be given IV or im. A lab that only draws blood would probably not be able to do this. Someone needs to order the acth and give the injection. ...Read more

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What is an acth stimulation test for?

What is an acth stimulation test for?

Adrenal test: It's a test to see if you have adrenal insufficiency (whether or not your adrenals are working). It typically requires a placement of an iv, blood draws from the IV line as well as injection of acth through the iv. It can be done in a doctor's office or in an infusion center. ...Read more

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What is the ab acth plasma stimulation test for?

What is the ab acth plasma stimulation test for?

Syncortropin?: If you're referring to the Cortrosyn or syncortropin test, it's an injection designed to stimulate cortisol production by your adrenal glands. Blood is drawn, generally one hour after injection, and values should increase by a certain amount to be considered normal. ...Read more

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Saliva cortisol tests are abnormally low. Serum cortisol tests are normal. Dr says i don't need an acth stim test due to serum results. Agree?

Saliva cortisol tests are abnormally low. Serum cortisol tests are normal. Dr says i don't need an acth stim test due to serum results. Agree?

Yes: If your saliva cortisol tests are low, then you have adrenal insufficiency. Acth stim test will only help determine if the cause is in the adrenal glands, pituitary gland or hypothalamus. Without other hormonal abnormalities or abnormal levels of sodium or potassium, this test is generally not needed and treatment for the adrenal insufficiency can be done. ...Read more

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Could a pituitary tumor cause delayed cortisol response on acth stim test?

Could a pituitary tumor cause delayed cortisol response on acth stim test?

Definitely: If the tumor has destroyed the pituitary's ability to respond appropriately to hypothalamic cortisol releasing hormone, it can even lead to secondary adrenocortical insufficiency. Check w/your doctor. ...Read more

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Acth stim test done. Acth was 12 at baseline cortisol 1. At 30 minutes cortisol was 22.7 then 1hr at 29. Does this indicate secondary ai?

Acth stim test done. Acth was 12 at baseline cortisol 1. At 30 minutes cortisol was 22.7 then 1hr at 29. Does this indicate secondary ai?

Adrenal insuff: The results of the acth stim test suggest that ai is not an issue. The cortisol level responded as expected to the stimulation. If at the start of the test, you were ill then it might suggest that you have a relative ai as your initial cortisol level was 1 (ok if your healthy and not stressed, but in an ill person the cortisol should be higher in response to stress). ...Read more

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Despite normal tilt table test & neg cortisol stim test, neuromd now ordered catecholamine testing for autonomic dysfuntion d/t my sx.If +, what is tx?

Despite normal tilt table test & neg cortisol stim test, neuromd now ordered catecholamine testing for autonomic dysfuntion d/t my sx.If +, what is tx?

I think u have: Orthostatic hupotension- a drop in blood pressure with changing position from a lying to an upright position. Follow up with them. Get checked for diabetes .Treatment depends on the underlying condition . Avoidance of sudden rising up will minimize the sx. If there's a regular drop in blood pressure, there are meds to sustain normal bp. Pls read link below. ...Read more

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What is the indication and contraindication of acth stimulation test? What is the management for acth stimulation test?

What is the indication and contraindication of acth stimulation test? What is the management for acth stimulation test?

See below: Acth stimulation allows a doctor to distinguish primary adrenal disease from pituitary disease. This is not an issue for self testing or management. See this site for more information and discuss the matter with your doctor. http://www.nlm.nih.gov/medlineplus/ency/article/003696.htm. ...Read more

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Serum cortisol 145 ng/ml, acth plasma 25. I have skin bronzing since two years.Should I do acth stimulation test as well?

Serum cortisol 145 ng/ml, acth plasma 25. I have skin bronzing since two years.Should I do acth stimulation test as well?

No: If it is 14.5 mcg/dl this is normal am cortisol.Bronzing is due to excess acth either from a low cortisol (addison's) or a pituitary or ectopic tumor making too much acth and elevated cortisol. See an endocrinologist. ...Read more

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ACTH challenge done10am, baseline ACTH less than 5, cortisol is at 8 (mayo range) symptoms of Adrenal fatigue, Autoimmune, pots. Tests still needed?

ACTH challenge done10am, baseline ACTH less than 5, cortisol is at 8 (mayo range) symptoms of Adrenal fatigue, Autoimmune, pots. Tests still needed?

What test?: Are you asking whether the ACTH challenge is needed after it has been done? This is best discussed with your endocrinologist who can explain to you the rationale behind his request. ...Read more

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Can a 24 urine cortisol test reliably rule out adrenal insufficiency? At what cortisol level?

Can a 24 urine cortisol test reliably rule out adrenal insufficiency? At what cortisol level?

Most helpful test: The 24 urine cortisol testing is one of the most sensitive tests and gives a better picture over the course of the day instead of just getting a sample from you a single time. There are blood tests and saliva tests which can be falsely be falsely elevated or falsely low depend L depending on your other medications and the time the test is performed. The best is to see an endocrinologist to help. ...Read more

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Exercise stress test, 24 hour holter monitor, echo doppler test--which is done first?

Exercise stress test, 24 hour holter monitor, echo doppler test--which is done first?

For what?: These tests provide different information and have different indications. Stress tests are to look for evidence to support a diagnosis of symptomatic blocked coronary arteries. Holtor is used to evaluate for dysthymia. Echocardiogram is useful to look at the heart valves and other features. Choosing the right test depends on what symptoms you are having. Discuss this with your doctor. ...Read more

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Acth stimulation test results accurate?

Depends: I'm assuming no lab errors. If you get a very high cortisol spike after receiving the first dose of ACTH, you are reassured you do not have Addison's. No, or a very small spike, strongly suggests Addison's. In-between... that's why there are specialist endocrinologists. ...Read more

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What is the definition or description of: acth stimulation test?

What is the definition or description of: acth stimulation test?

Eval adrenal functio: The acth stimulation test evaluate whether the adrenal gland can respond to stimulation from the pituitary gland by giving an artificial form of the pituitary hormone (acth) and measuring the adrenal gland hormone (cortisol) before and after the injection. Normally the cortisol level will rise after the injection; in most instances failure to do so indicates a problem with the adrenal gland. ...Read more

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ACTH stimulation test. Base 9.8 mcg/dl 30 min: 28.7 and 60 min: 37.3 is this normal?

ACTH stimulation test. Base 9.8 mcg/dl
30 min: 28.7 and 60 min: 37.3 is this normal?

Yes: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Talk to the doctor who ordered the tests. Having said that, your results are in the normal range. Visit this site for more info:
https://medlineplus.gov/ency/article/003696.htm ...Read more

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Regarding acth stimulation test. Do I have to be experiencing symptoms at time of test in order for it to show positive result?

Regarding acth stimulation test. Do I have to be experiencing symptoms at time of test in order for it to show positive result?

No symptoms needed: The test is designed to test the ability of your adrenal glands to respond to stimulation from the pituitary (by giving a synthetic form of the pituitary hormone), so it is not necessary to have symptoms for the test to be valid. The ability of the adrenal gland to respond to stimulation does not come and go on a short term basis, so the results will be the same no matter how one feels. ...Read more

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What is an acth stimulation test for?

Adrenal test: It's a test to see if you have adrenal insufficiency (whether or not your adrenals are working). It typically requires a placement of an iv, blood draws from the IV line as well as injection of acth through the iv. It can be done in a doctor's office or in an infusion center. ...Read more

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ACTH Stimulation Test results: baseline cortisol 6.2, 30 min 19.4, 1 hour 22.7. Suspect SAI?

ACTH Stimulation Test results: baseline cortisol 6.2, 30 min 19.4, 1 hour 22.7. Suspect SAI?

While there can be: variation between labs, these results appear to be largely normal. The baseline is normal (5-23 micrograms per deciliter). A rise from baseline of at least 7 to 10 ug/dl of cortisol, reaching at least 18 ug/dl at 60 minutes post-stimulation rules out primary adrenal insufficiency. A blunted response (not sure yours qualifies) may suggest secondary AI. Your Doctor will advise you. Stay well. ...Read more

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Can i drive myself after acth stimulation test or should I have someone drive me? I don't know what to expect? Might i feel better or worse after ?

Can i drive myself after acth stimulation test or should I have someone drive me? I don't know what to expect?  Might i feel better or worse after ?

Yes: An acth stim test. A cortisol blood test, an injection of cortrisyn followe by another cortisol blood test. It takes time, but you should be able to drive to and from work. Best wishes. ...Read more

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Acth stimulation test -- is that done in a lab?

Yes and no.: Provocative acth is given iv. Serial blood measurements are made for detecting the rise in cortisol in the blood. These assays are done in a lab. ...Read more

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What is the indication and contraindication of acth stimulation test? What is the management for acth stimulation test?

See below: Acth stimulation allows a doctor to distinguish primary adrenal disease from pituitary disease. This is not an issue for self testing or management. See this site for more information and discuss the matter with your doctor. http://www.nlm.nih.gov/medlineplus/ency/article/003696.htm. ...Read more

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I've been showing strong symptoms of addisons disease.Should i opt for an acth stimulation test?

Yes if indicated: If you have symptoms of adrenal insufficiency, talk to your doctor about the acth stim test. This is the best test to confirm your suspicion. If he/she agrees with your assessment, the test should be ordered. Good luck. ...Read more

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Is acth stimulation test done at a normal lab that draws blood?

ACTH test: The lab can draw blood for measurement of cortisol, but someone has to give the injection of acth (cortrosyn). The injection can be given IV or im. A lab that only draws blood would probably not be able to do this. Someone needs to order the acth and give the injection. ...Read more

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Acth Stimulation test: PRG 17-0H basal: 3.70nmol/l 30min interval: 9.83nmol/l 60min interval: 12nmol/l Heterozygous or Homozygous NCAH? Or Pcos?

Acth Stimulation test:
PRG 17-0H basal: 3.70nmol/l 
30min interval: 9.83nmol/l
60min interval: 12nmol/l
Heterozygous or Homozygous NCAH? Or Pcos?

NCAH or PCOS?: Not nonclassic adrenal hyperplasia with early morning 17-OH progesterone less than 200ng/dl. Yours, with conversion is 122ng/dl. Also, your stimulated level doesn't reach higher than 400ng/L. That means no 21-hydroxylase or 11beta-hydroxylase or 3-beta-hydroxysteroid dehydrogenase or 17-alpha-hydroxylase deficiency. PCOS. ...Read more

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Can prednisone affect an acth stimulation test? I'm on 5 mg daily for months and will have test in 1 week!

Yes: Normally switch patients to Hydrocortisone for a week before a stim test. It is short acting Prednisone will keep acth suppressed and not allow your pituitary respond to stimulate cortisol production. ...Read more

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After acth stimulation test confirms adrenal insufficiency does it always need to be treated and/or followed up and how often?

Yes: Adrenal insufficiency means that your body is not able to produce enough steroids. Depending on the cause of adrenal insufficiency, you can be deficient in more than one steroid (cortisol and/or aldosterone). Your body needs these hormones, so it is important to follow-up with your dr. The frequency depends on how stable the disease is for the patient. ...Read more

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Acth plasma and cortisol blood tests were normal but I have strong addisons symptoms with bronzing.What to do? Should I do an acth stimulation test?

Not an issue for : Self diagnosis. I trust that you are under the care of an endocrinologist, if not, it would be prudent to consult one and follow his/her advice. ...Read more

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Serum cortisol 145 ng/ml, acth plasma 25. I have skin bronzing since two years.Should I do acth stimulation test as well?

No: If it is 14.5 mcg/dl this is normal am cortisol.Bronzing is due to excess acth either from a low cortisol (addison's) or a pituitary or ectopic tumor making too much acth and elevated cortisol. See an endocrinologist. ...Read more

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Acth stimulation test w/poor response. I was told to wear a med bracelet and take prednisone. How do I know if it's addison's vs adrenal isufficiency?

Acth stimulation test w/poor response. I was told to wear a med bracelet and take prednisone. How do I know if it's addison's vs adrenal isufficiency?

Antibody: You have adrenal insufficiency. That's already proven on your acth stim test. Addison is one cause for adrenal insufficiency. The diagnosis is made by checking for adrenal antibodies. ...Read more

Dr. Quang Nguyen
148 doctors shared insights

Adrenocorticotropic Hormone (Definition)

It is one of several pituitary hormones - acth for short (the others control the thyroid gland, gonad glands, and others) that controls adrenal gland function in primarily making the hormone called cortisol (not to be confused with "adrenaline"), though the adrenal gland also ...Read more