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Doctor insights on: Acth Resistance

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What is an acth test?

What is an acth test?

Adrenal function: As usually used, the term means having acth, the hormone that makes the adrenal glands produce the cortisol you need to live, injected. There should be a huge spike in your blood cortisol shortly after; if not, it is likely that you have adrenal insufficiency and will need to be treated for it. ...Read more

Tolerance (Definition)

When one takes a drug, such as heroin or alcohol, repeatedly, 'tolerance' develops because more of the drug is needed to give the same effect on the body/brain; e.g. Liver enzymes r stimulated to metabolize the drug faster and faster. There may be a strong genetic predisposition to addiction, some studies suggesting that 1 of 10 people will become dependent on alcohol or some ...Read more


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Acth level in cushings?

Acth level in cushings?

High in Cushing's: Elevated. Melanocortin secretion is also high and gives rise to frequent hyperpigmentation. ...Read more

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What does a acth level mean?

What does a acth level mean?

A pituitary check.: Acth is adrenocorticotrophic hormone. It is produced in the pituitary gland. It works to stimulate your adrenal glands to make cortisol each day. Acth production is related to your circadian rhythm (rises in the early morning) and other factors, like stress. Doctors may check the acth level to see how the pituitary gland is responding to abnormal levels of cortisol in the blood. ...Read more

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I have high ACTH level what does it mean ?

I have high ACTH level what does it mean ?

Need more info: Hi. Have you been diagnosed with Cushing's? If not, it means nothing. Illness and physiologic stress can drive up ACTH, and ACTH shows diurnal variation. Without knowing the time of day it was drawn and your physiologic circumstances, it means nothing. And yet, the doc who ordered it was considering something, so really don't have enough info to say. Good luck! ...Read more

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After being on hc of 20-30mg for 7 yrs for partial ai, and acth remains in normal range on hc (not suppres'd) and is > 65 after 1 day off hc, can mayo determine if partial ai is primary or secondary?

After being on hc of 20-30mg for 7 yrs for partial ai, and acth remains in normal range on hc (not suppres'd) and is > 65 after 1 day off hc, can mayo determine if partial ai is primary or secondary?

Yes: If you really need hydrocortisone, then it would be dangerous do delete it totally. Speak w/your doctors and follow their recommendations. Your acth is higher than would be expected if you're taking hc regularly. Cortisol level may reflect hc still in your system or your endogenous production. Very complicated case that needs one-on-one analysis, not the internet. ...Read more

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Can an ACTH (cosyntropin) test make me sick?

Can an ACTH (cosyntropin) test make me sick?

Not usually: Cosyntropin breaks down very quickly after it is given, so any symptoms are usually very short-lived (3-5 minutes). These symptoms may include flushing, feeling hot, lightheadedness, nausea, funny taste in the mouth, and feeling like you have to urinate. These symptoms can be alarming because they occur suddenly, but do go away quickly. Fortunately, most people have no symptoms at all. ...Read more

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What would cause your acth blood levels to change?

What would cause your acth blood levels to change?

Life: Spot acth levels fluctuate tremendously just from the transient stresses of living, or even without. Even if elevated from disease, they'll fluctuate wildly. This is why we try to suppress them and if we can't, disease is likely. ...Read more

Dr. William Singer
143 doctors shared insights

Adrenocorticotropic Hormone (Definition)

It is one of several pituitary hormones - acth for short (the others control the thyroid gland, gonad glands, and others) that controls adrenal gland function in primarily making the hormone called cortisol (not to be confused with "adrenaline"), though the adrenal gland also ...Read more