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Doctor insights on: Acth Resistance

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Tiny adrenal tumor, h cortisol, h testosterone, h creatinine, h dheas, fast gluc 106. Hysterectomy, thyromegaly Will metformin reduce testosterone?

Tiny adrenal tumor, h cortisol, h testosterone, h creatinine, h dheas, fast gluc 106.   Hysterectomy, thyromegaly
Will metformin reduce testosterone?

Hormones: Metformin medicine that keeps your blood sugar under control should not have an effect on testosterone. That said, too much metformin will likely lower your testosterone. Are you checking your blood sugar regularly? Please let me know how things are going. ...Read more

Tolerance (Definition)

When one takes a drug, such as heroin or alcohol, repeatedly, 'tolerance' develops because more of the drug is needed to give the same effect on the body/brain; e.g. Liver enzymes r stimulated to metabolize the drug faster and faster. There may be a strong genetic predisposition to addiction, some studies suggesting that 1 of 10 people will become dependent on alcohol or some ...Read more


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Acth level in cushings?

Acth level in cushings?

High in Cushing's: Elevated. Melanocortin secretion is also high and gives rise to frequent hyperpigmentation. ...Read more

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How does oral cortisol affect acth hormone and aldosterone levels?

How does oral cortisol affect acth hormone and aldosterone levels?

Poor correlation: Hi. Oral cortisol (aka hydrocortisone) does not reliably affect ACTH secretion nor aldosterone levels. That is somewhat unfortunate for those of us treated adrenal insufficiency, since determination of proper dose is based solely on clinical response, and not labs. Aldosterone is driven by the renin-angiotensin system bypassing the pituitary. UIHC is excellent, so you have great docs close at hand ...Read more

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Can increased prolactin cause insulin resistance?

Can increased prolactin cause insulin resistance?

Probably not: I am not aware of high prolactin causing Insulin resistance. However, some people with Insulin resistance and polycystic ovarian syndrome can have high prolactin levels. ...Read more

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Basal glucose =81 mg/dl but insuline =38 mU/ml (insuline/glucose > 0,3 ). Symptoms of ipoglycemia... How to exclude an insulinoma? Ultrasound?thanks!

Basal glucose =81 mg/dl but insuline =38 mU/ml (insuline/glucose > 0,3 ). Symptoms of ipoglycemia... How to exclude an insulinoma? Ultrasound?thanks!

Hypoglycemia: To diagnose insulinoma, you need to demonstrate inappropriately high insulin/C-peptide when your glucose is low. A glu of 81 is not low, it is normal. You have symptoms of hypo, but these symptoms are often from something else. Insulinoma is rare. Do not start getting CT/ultrasound etc until you establish the biochemical diagnosis first. An Endocrinologist can help you. ...Read more

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Does insulin resistance affect fertility hormones such as fsh, estradiol?

Does insulin resistance affect fertility hormones such as fsh, estradiol?

To some extent!: The single most common abnormality is a slightly high or borderline total testosterone and significantly increased free testosterone due to a low sex hormone binding globulin in females. Estrogen is unaffected! however, because of increased intra-abdominal fat which contains cyclic aromatase, which converts androsteindione to estrone and testosterone to estradiol, men have higher estrogens! ...Read more

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Consistently high LH level, always high lh:fsh ratio, last result showed 14.4 LH to 6.6 fsh. Do I have insulin resistance or hyperinsulinemia?

Consistently high LH level, always high lh:fsh ratio, last result showed 14.4 LH to 6.6 fsh. Do I have insulin resistance or hyperinsulinemia?

Maybe (not) . . .: Can't tell anything about Insulin resistance or hyperinsulinemia by measuring your lh & fsh. When you're young & menstruating, your lh & fsh will vary throughout your cycle. Once you go thru menopause, your lh & fsh remain elevated. If you want to determine if you're resistant to Insulin or have high Insulin levels, just measure fasting insulin. ...Read more

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Blood insulin=29.5 On lantus (insulin glargine) 62 units, humalog 17 units. Am I still producing endogenous insulin?

Blood insulin=29.5 On lantus (insulin glargine) 62 units, humalog 17 units.  Am I still producing endogenous insulin?

Need more info: Most people diagnosed with type 2 diabetes continue to make insulin for many years. The way to tell this is by measuring a blood level of c-peptide. Also- Since you are only 45, if you are not obese, would check with your doctor to see if you might have later onset type 1. ...Read more

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Could a pituitary tumor cause delayed cortisol response on acth stim test?

Could a pituitary tumor cause delayed cortisol response on acth stim test?

Definitely: If the tumor has destroyed the pituitary's ability to respond appropriately to hypothalamic cortisol releasing hormone, it can even lead to secondary adrenocortical insufficiency. Check w/your doctor. ...Read more

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Does acth causes both aldosterone and cortisol secretion?

Does acth causes both aldosterone and cortisol secretion?

ACTH ALDO Cortisol: I have seen two families in which ACTH is the major driver for aldo production. They have the syndrome called GRA (Glucocorticoid Remedial Aldosteronism) caused by a cross over mutation in the genes controlling aldo production so that the major controller of aldo is ACTH. As you are young and making this question if you also have HTN your team should consider this. Many do not have low K. ...Read more

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Insulin resistance? fasting insulin 76pmol/l after 75gOral glucose- 1hr-insulin-849pmol/l . 2 hr-864pmol/l glucose fast 5.4mmol/l 1hr10.4 2hr7.5

Insulin resistance? 
fasting insulin 76pmol/l 
after 75gOral glucose- 
1hr-insulin-849pmol/l . 2 hr-864pmol/l

glucose fast 5.4mmol/l
1hr10.4
2hr7.5

Time to get serious: You have normal glucose tolerance. Your fasting and 2 hr glu is not quite at the level of "impaired". Your insulin levels are on the high side, suggesting insulin resistance. Now is the time to start getting your weight under control, proper diet, and physical activity. Talk to your doctor about your particular situation. ...Read more

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What is plasma acth cortisol response?

What is plasma acth cortisol response?

Test adrenal fxn.: This test is to check on whether or not your adrenal glands are working right. The acth action is to increase production and release of corticosteroids. In the test, a small amount of synthetic acth is injected and the amount of cortisol the adrenals produce in response is measured. This is used to check for things like primary and secondary adrenal insufficiency, and addison's disease. ...Read more

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Could adrenal glandulars increase dhea and testosterone levels?

Could adrenal glandulars increase dhea and testosterone levels?

Yes: Glandulars have been a traditional source of these hormones, but there absorption is not realiable. Check with your doctor or check out acam which is an organization that has investigated and held standards on hormone supplementation. They even have a physician referral on there website. ...Read more

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Will nutrasweet affect insulin resistance?

Will nutrasweet affect insulin resistance?

Insulin resistance: Nutrasweet is two amino acids. I have seen no papers relating the two. Most common cause for Insulin resistance is obesity. The use of sugar substitute is first step in improvement. ...Read more

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Type II diabetic, blood insulin last test (NOT glucose)=29.5 On lantus (insulin glargine) 62 units, humalog 17 units. Am I still producing endogenous insulin?

Type II diabetic, blood insulin last test (NOT glucose)=29.5 On lantus (insulin glargine) 62 units, humalog 17 units. Am I still producing endogenous insulin?

Need C-peptide test: Since exogenous (injected) insulin will show on a blood test, C-peptide should be measured to assess for endogenous insulin. Proinsulin is made by the pancreas, then cleaved into C-peptide & insulin. Exogenous insulin has no C-peptide. ...Read more

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Is PCOS or non classic CAH?FSH/LH are 1:3 ratio Testosteron Androstenedion 17Oh Progesteron are high Cortizol DHEA-S SHBG PROLACTIN Normal ACTH low

Is  PCOS or non classic CAH?FSH/LH are 1:3 ratio Testosteron Androstenedion 17Oh Progesteron are high Cortizol DHEA-S SHBG PROLACTIN  Normal ACTH low

ACTH stimulation: If you have features of both problems, the male hormone levels and menstrual irregularities and infertility are the hallmarks of a diagnosis of PCOS. What does your Endo or Gyne/Endo say about this ? Ask them for answers, which may include an ACTH stim test to see how your pituitary axis is functioning to start with, followed by more adrenal function testing... ...Read more

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Does an insulin pump automatically control blood glucose levels?

Does an insulin pump automatically control blood glucose levels?

NO!: Hi. No, pumps only do what you, the user and programmer, tell them to. There is one pump out now in conjunction with a continuous glucose monitor (CGM) that has an insulin suspend function, but that's still a far cry from automatic control. At this point, CGM is FAR MORE beneficial to the diabetic than a pump. Be patient...the fully automatic pump will come in our lifetime. Good luck! ...Read more

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Will T3 (liothyronine) cure adrenal insufficiency?

Will T3 (liothyronine) cure adrenal insufficiency?

No: Adrenal insufficiency is the result of the failure of the adrenal glands to make cortisol. T3 (liothyronine) will not treat adrenal insufficiency because it is a thyroid hormone. ...Read more

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Is insulin resistance the same as hyperinsulinism?

Is insulin resistance the same as hyperinsulinism?

You are correct: Insulin resistance refers to the body needing higher level of Insulin to keep the sugar level down to normal or close to normal. Hyperinsulism = body has higher level of Insulin in circulation at virtually all time. So, the terms are of same meaning, at least with regard to diabetes/Insulin resistant state. If u have concern, consult doc. Good luck. ...Read more

Dr. Brad Goldenberg
147 doctors shared insights

Adrenocorticotropic Hormone (Definition)

It is one of several pituitary hormones - acth for short (the others control the thyroid gland, gonad glands, and others) that controls adrenal gland function in primarily making the hormone called cortisol (not to be confused with "adrenaline"), though the adrenal gland also ...Read more