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Doctor insights on: Acth Resistance

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What is an acth test?

What is an acth test?

Adrenal function: As usually used, the term means having acth, the hormone that makes the adrenal glands produce the cortisol you need to live, injected. There should be a huge spike in your blood cortisol shortly after; if not, it is likely that you have adrenal insufficiency and will need to be treated for it. ...Read more

Tolerance (Definition)

When one takes a drug, such as heroin or alcohol, repeatedly, 'tolerance' develops because more of the drug is needed to give the same effect on the body/brain; e.g. Liver enzymes r stimulated to metabolize the drug faster and faster. There may be a strong genetic predisposition to addiction, some studies suggesting that 1 of 10 people will become dependent on alcohol or some ...Read more


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Acth level in cushings?

Acth level in cushings?

High in Cushing's: Elevated. Melanocortin secretion is also high and gives rise to frequent hyperpigmentation. ...Read more

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What does a acth level mean?

What does a acth level mean?

A pituitary check.: Acth is adrenocorticotrophic hormone. It is produced in the pituitary gland. It works to stimulate your adrenal glands to make cortisol each day. Acth production is related to your circadian rhythm (rises in the early morning) and other factors, like stress. Doctors may check the acth level to see how the pituitary gland is responding to abnormal levels of cortisol in the blood. ...Read more

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I have high ACTH level what does it mean ?

I have high ACTH level what does it mean ?

Need more info: Hi. Have you been diagnosed with Cushing's? If not, it means nothing. Illness and physiologic stress can drive up ACTH, and ACTH shows diurnal variation. Without knowing the time of day it was drawn and your physiologic circumstances, it means nothing. And yet, the doc who ordered it was considering something, so really don't have enough info to say. Good luck! ...Read more

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After being on hc of 20-30mg for 7 yrs for partial ai, and acth remains in normal range on hc (not suppres'd) and is > 65 after 1 day off hc, can mayo determine if partial ai is primary or secondary?

After being on hc of 20-30mg for 7 yrs for partial ai, and acth remains in normal range on hc (not suppres'd) and is > 65 after 1 day off hc, can mayo determine if partial ai is primary or secondary?

Yes: If you really need hydrocortisone, then it would be dangerous do delete it totally. Speak w/your doctors and follow their recommendations. Your acth is higher than would be expected if you're taking hc regularly. Cortisol level may reflect hc still in your system or your endogenous production. Very complicated case that needs one-on-one analysis, not the internet. ...Read more

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Can an ACTH (cosyntropin) test make me sick?

Can an ACTH (cosyntropin) test make me sick?

Not usually: Cosyntropin breaks down very quickly after it is given, so any symptoms are usually very short-lived (3-5 minutes). These symptoms may include flushing, feeling hot, lightheadedness, nausea, funny taste in the mouth, and feeling like you have to urinate. These symptoms can be alarming because they occur suddenly, but do go away quickly. Fortunately, most people have no symptoms at all. ...Read more

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What would cause your acth blood levels to change?

What would cause your acth blood levels to change?

Life: Spot acth levels fluctuate tremendously just from the transient stresses of living, or even without. Even if elevated from disease, they'll fluctuate wildly. This is why we try to suppress them and if we can't, disease is likely. ...Read more

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I had the "acth, plasma" test done. What is this for?

I had the "acth, plasma" test done. What is this for?

Test adrenal fxn.: This test is to check on whether or not your adrenal glands are working right. It is produced and secreted by the anterior pituitary gland. It is often produced in response to biological stress. Its action is to increase production and release of corticosteroids. A deficiency of acth results in secondary adrenal insufficiency and an excess of it results in cushing’s syndrome. ...Read more

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Can acth test give false addison's disease diagnosis?

Anything is: Possible, and such an important test should always be repeated for confirmation before you are placed on what will almost certainly be a life-long and potentially dangerous medication regimen. See a specialist. ...Read more

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What health issues are related to high ACTH and high prolactin?

What health issues are related to high ACTH and high prolactin?

Pituitary: Both hormones are produced by your pituitary. So processes that effect your pitiuitary. That can be primary pituitary gland problems, but often the gland can be effected by stress or other medical problems. ...Read more

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What is acth stim test and does it make a person uncomfortable to have it?

What is acth stim test and does it make a person uncomfortable to have it?

ACTH test: Test is indicated to measure adrenal reserve blood taken , given acth intravenously and blood obtained generally twice at 30 minute intervals test has no side effects and not uncofortale. ...Read more

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On Cort Stim test, results, ACTH 6.1 , cortisol 18.5 and 22.7, is this normal?

If the test: was done properly in the morning, these results would be considered normal. ...Read more

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Could acth defeincy be to blame for trouble waking up every morning for the past 2 yrs?

Could acth defeincy be to blame for trouble waking up every morning for the past 2 yrs?

Possibly: Patients with central adrenal insufficiency, acth deficiency, can have fatigue and lethargy. If you have already been diagnosed with this condition, you should talk to your doctor to see if your steroid dose needs to be increased. If you have not been diagnosed with adrenal insufficiency, within 2 years, it's unlikely that is your problem, as patients typically become ill from that condition. ...Read more

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Acth level is less than 1.0 with normal cortisol (8). Does this indicate any issues with thyroprotein level of 3? Thanks

Acth level is less than 1.0 with normal cortisol (8).  Does this indicate any issues with thyroprotein level of 3?  Thanks

Pituitary: If we suspect cortisol insufficiency, need to do stimulation tests. Random ACTH, Cortisol are not reliable..they are pulsatile harmones. Your random cortisol is in range. ...Read more

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Acth stim test coming up. my sleep sched is different than most--i sleep 5am-2pm each day. so what time should they do my test?

Acth stim test coming up. my sleep sched is different than most--i sleep 5am-2pm each day. so what time should they do my test?

Won't matter: It should not matter. Although your circadian rhythm will affect the baseline cortisol, ACTH should stimulate it regardless of the time of day. If cortisol goes up to 20 or more, you are fine. ...Read more

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Acth stim test done. Acth was 12 at baseline cortisol 1. At 30 minutes cortisol was 22.7 then 1hr at 29. Does this indicate secondary ai?

Acth stim test done. Acth was 12 at baseline cortisol 1. At 30 minutes cortisol was 22.7 then 1hr at 29. Does this indicate secondary ai?

Adrenal insuff: The results of the acth stim test suggest that ai is not an issue. The cortisol level responded as expected to the stimulation. If at the start of the test, you were ill then it might suggest that you have a relative ai as your initial cortisol level was 1 (ok if your healthy and not stressed, but in an ill person the cortisol should be higher in response to stress). ...Read more

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ACTH stim test...I've seen so many reference ranges I don't know how to interpret mine with 12.8 baseline, 20.4 @ 30 and 21.1 @ 60 minutes?

ACTH stim test...I've seen so many reference ranges I don't know how to interpret mine with 12.8 baseline, 20.4 @ 30 and 21.1 @ 60 minutes?

Endocrinologist: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. An ACTH stimulation test is not a do it yourself matter and the results should be interpreted by an endocrinologist. ...Read more

Dr. Ira Katz
146 doctors shared insights

Adrenocorticotropic Hormone (Definition)

It is one of several pituitary hormones - acth for short (the others control the thyroid gland, gonad glands, and others) that controls adrenal gland function in primarily making the hormone called cortisol (not to be confused with "adrenaline"), though the adrenal gland also ...Read more