Doctor insights on:
Acquired Adrenal Hyperplasia
CAH?: Do you mean congenital adrenal hyperplasia? There are adult forms of this. It occurs when there is an enzyme defect in adrenal steroid synthesis such that excess adrenal androgens are made. In extreme cases, female babies are born with male-like genitalia. In mild forms, it looks like pcos in adulthood. Treatment can be complicated, and should be by an endocrinologist (medicine or gyn).
My baby has taken two test one showed he didn t have congential adrenal hyperplasia and the other should he actually did what I should I do?
Depends on situation: The first screening test done at a day or so can be falsely positive. The second screening test done at a week or later is more accurate. There are specific tests that can be done on the blood to sort out confusing results & are usually done with the aid of a metabolic specialist or pediatric endocrinologist.
Enzyme defeciency: This disease results from deficiency of an enzyme, 21 hydroxylase, that is essential for synthesis of adrenal hormones. Block in the synthesis of glucoroticoids causes excess production of male sex hormones. See this site for more information. Http://www. Ncbi. Nlm. Nih. Gov/pubmedhealth/pmh0001448/.
Enzyme deficiency: Deficiency of 21 hydroxylase enzyme needed for synthesis of gluco- and mineralo-corticoids causes excessive production of sex hormones, mainly male sex hormones. The result is endocrine disturbance in both boys and girls and virilization in girls.
Forever: This is a lifelong genetic issue. Medication & monitoring can decrease the impact on one's life, but it is not like a pneumonia, it doesn't go away after treatment.
Missing enzyme: There are different types. They all involve a deficiency of an enzyme needed in cortisol production. Since the pituitary senses there isn't enough cortisol, it keeps trying to make the adrenals make cortisol. But because that enzyme is missing, the building blocks of cortisol build up. These substances get turned into androgens - male hormones - and cause abnormalities in sexual development.See 2 more doctor answers
Classic or non?: Classic cah is diagnosed mostly on newborn screening. It results from a block in the synthesis of cortisol and usually also aldosterone. Females will often have ambiguous genitalia. Males don't look different. Permanent replacement with Hydrocortisone & Fludrocortisone (may not need past childhood) are needed for sustaining life and salt balance. Pediatric endocrinologists follow very closely.See 1 more doctor answer
Yes: Persons with the most common form congenital adrenal hyperplasia (cah) have a predisposition to making extra testosterone. For girls this can manifest as genitalia that is "masculinized" before birth and therefore "ambiguous" at the time of birth. Girls can also have somewhat masculinized behaviors. The testosterone levels can be lowered by therapy. Boys do not have genital or behavioral issues.
CAH: This is due to the lack of an enzyme needed for the adrenals to make cortisol and aldosterone. The body then uses the precursors to make androgen (male hormones) instead. Symptoms for girls: deep voice, abnormal menstruation, early appearance of pubic/armpit hairs, genitials looking both male and female...For boys: deep voice, enlarged penis, small testes, early appearance of pubic, armpit hair...See 1 more doctor answer
1:15, 000: Cah is found in 1 of every 15, 000 live births.
Yes: These people have a gene that makes it hard to make the necessary hormone cortisol, and the molecules get shunted into producing masculinizing hormones instead. The adrenals are big. In mild cases, it simply produces extra body hair in women. In severe cases, a little girl's genitals are ambiguous from birth, or a little boy reaches puberty at a very early age.
See below: It is a collection of genetic conditions that limit your adrenal glands' ability to make certain vital hormones. In most cases of congenital adrenal hyperplasia, the adrenal glands don't produce enough cortisol. The production of two other classes of hormones also may be affected, including mineralocorticoids (for example, aldosterone) and androgens (for example, testosterone).
Depends on the type: Of enzyme defect and the gender of the patient. Congenital adrenal hyperplasia is a group of disorders that affect the hormones produced by adrenal gland. The disorders affect electrolyte and sex hormones and may cause ambiguous sexual organs in girls. See this site for more information. Http://www. Ncbi. Nlm. Nih. Gov/pubmedhealth/pmh0001448/.
Unclear question: You did not provide any symptoms or signs and it is not feasible to answer the question without examining you and doing some blood tests. Please consult a doctor for an evaluation.
Hormone imbalance: Deficiency of 21 hydroxylase enzyme results in reduced synthesis of gluco- and mineralo- corticoids and excess production of male sex hormones. There is not way to "fight" the disease, but it can be treated with glucocorticoids, e.g., predinisolone. The defect causes virilization in girls an pre-mature puberty in boys.
Genetic defect: There is more than one type of inherited enzyme defect that results in lack of normal adrenal hormones and enlargement of the gland. It results in electrolyte abnormalities and defects of sex organs. See this site for more info. Http://www. Mayoclinic. Com/health/congenital-adrenal-hyperplasia/ds00915.
Varies: This situation is extremely serious even if the illness is mild. There are various ways of treating it, but you need to discuss this with Junior's physician. I am glad it was diagnosed.
I have nonclassic adrenal hyperplasia. What else can be done to lower my androgen levels besides 300mg spiro?
Endocrinologist: What does your endocrinologist say?Get a more detailed answer ›
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