Doctor insights on:
Ach Receptor Binging Ab
An organ, cell or molecule that accepts an outside signal and causes an internal change. Eyes receive light, touch receptors send messages to the brain when stimulated by pressure and estrogen receptors bind Estradiol causing responses of normal breast, ovary and uterus cells to rising and falling levels of the female steroid hormones. Most of the time "receptor" refers to one ...Read more
How do dopamine antagonist help opioid nausea if opioid nause is mediated through opioid receptors and not dopamine?
interrelated: All receptor systems are interrelated and interact with each other. Whatever induces nausea, the reaction is triggered by dopaminergic pathways in a part of the brain called the chemoreceptor trigger zone. Most anti-emetics work by antagonizing dopamine. The combination of opioids and antinausea medications is quite common, both for synergism and to reduce nausea. ...Read more
Are NMDA receptors destroyed when u have anti-nmda receptor encephalitis..Or do NMDA receptors just become dysfunctional (over/under active)or both?
Anti-NMDA receptor e: The disease is associated with tumors, mostly teratomas of the ovaries, and is considered a paraneoplastic syndrome. However, there are a large number of cases with no detectable cancers. It is not clear what exactly takes place, but since many patients recover entirely, often when the cancer is treated, the receptors have obviously not been destroyed. ...Read more
I get savage irrational rage & full-body dysesthesia when eating food high in aspartic, glutamic, & arachidonic acid. Why? Nmda receptor dysfunction?
Elevated EBV ab VCA IgG <8 and EBV nucleaer antigen ab IgG test 4.2. & anti-dna(ss)igg ab qn ( 119)& c react protien(5.6) what are implications?
Nothing.: Ebv antibodies indicate you had a previous infection, but not active. The c-reactive protein needs a units indicator - that is either normal or somewhat elevated. The anti ss dna is extremely nonspecific and very rarely indicated; I have no idea why that was ordered, discuss with your doctor. ...Read more
Tested for acetylcholine receptor ab panel; both binding and blocking were 0, but modulating came back at 10. Does this mean I have myasthenia gravis?
AchRAntibodies: Binding antibodies are the most sensitive--they are positive in over 80% of ms patients. Blocking antibodies are positive in about half. Modulating antibodies alone don't support the diagnosis and have a lot oof false positives. In summary the achreceptor antibody panel does not suggest that ou have ms>. ...Read moreSee 2 more doctor answers
somewhat: People with autoimmune thyroid disease can be positive for both antibodies. ...Read more
Low positive ana, dual pattern speckled, centromere. Positive aca and positive histone ab igg. After c/o skin rash and moderate right hip pain.
Need to be evaluated: A low titer (concentration) ANA test is not particularly helpful to make a diagnosis. Even with a particular pattern (speckled) and anti-centromere antibodies and anti-histone antibodies. Your rash and hip pain are more important as well as inflammatory markers like an ESR and a CBC if they are normal or not. See your doctor and ask for a referral to a rheumatologist if you are concerned. ...Read more
What would cause an intolerance to glutamic acid? Gad autoantibodies? Gad deficiency? Glutamate receptor autoantibodies(anti-nmda, anti-ampa)?
None of the above.: Msg - ubiquitous Amino Acid and major excitatory neurotransmitter in brain. Studied extensively. Does not cause allergy or intolerance except at high dose and only then in susceptible persons when given in large doses without food. See fda, j. Nutrition, food chem and toxicology, etc. ...Read moreSee 1 more doctor answer
Can autoantibodies against glutamine synthetase and/or glutamate dehydrogenase cause glutamate metabolism disorders?
Still searching: Glutamine synthase is part of the glutamine synthetase family. Ammonia incorporation in animals occurs through the actions of glutamate dehydrogenase and glutamine synthase. Glutamate plays the central role in mammalian nitrogen flow, serving as both a nitrogen donor and nitrogen acceptor. I am unble to find references in my search so far as to autoantibodies to these but see comment. ...Read more
L-glutamic acid gives me severe dysesthesias. D-glutamic acid is worse. Could I have glutamate metabolism disorder or glutamate receptor antibodies?
Possibly but...: Good question without an easy answer. Glutamate is an "excitotoxin" that is not healthy for anyone but some people are more sensitive to it than others. There are a variety of uncommon glutamate metabolism disorders but you do not need to have one of these to be adversely affected by glutamate. Dysesthesias are not a known symptom of antibodies to glutamate receptors. See my comments:. ...Read more
30yrs 5'3" 180lbs, 1 child. Main issues, Weight/ Fatigue/ Heart Palp./LowTemp/Eyebrowloss/Cold TSH 3.59,FT4 .9, TPO 1, ANA ifa, POS 1:320titer?
Yes, but...: In test tubes, buprenorphine binds to mu opiod receptor more avidly than does tramadol. But analgesia is a very different concept, and depends on nature of pain, chronicity of it, dose and duration of drug, and individual genetic characteristics (such as expression of splice variants of mu opiod receptor). For some people tramadol is better analgesic; for others, the reverse. ...Read more
Muscle wasting, eating plenty,insulin resist. pancreatic beta cell dysfunction fructosamine and post prandial high, insulin level @2 what does it mean?
I have positive ana, positive anti-centromere & anti-histone ab igg. R hip, b shoulder pain. Rash, sleep disturbance, sob. What should I do next?
See a rheumatologist: Have a rheumatologist evaluate the issues, . ...Read more
41 yo man w/familial Achase Def. Achase Inh meds make no sense as Tx or DO THEY? Could EXCESS Ach in system paradoxically improve Sx of Ach excess?
You're right, if he : has Endplate AChE Deficiency, CMS 5, an AR disorder from a mutant COLQ gene on Chr. 3p25.1. From www.omim.org/entry/603034, "patients had absence of AChE from the NMJ, which explained the lack of clinical benefit from AChE inhibitors." The ACHE gene on Chr. 7q22.1's hyper-reactivity to AChE Inhibitors is on omim.org/entry/100740. Or, on OMIM. org, search AChE Deficiency & AChE Excess. ...Read more
Explain my ANA?
dsDNA Ab "1"
ENA RNP Ab <0.2
ENA SM Ab Ser-aCnc <0.2
Scleroderma SCL-70 <0.2
all others <0.2 aswell.
dr sending me to rheumatologist.
Ask rheum: Your rheumatologist will be able to tell you much more after examining you. I am glad you are heading to the right specialist. ...Read more
Yes.: Receptors are bound, unbound and replaced all the time. ...Read more
Epstein-barr tst rslts - what do they mean? Ref rng <0.91, VCA ab in rng, VCA ab IgG 4.46 out +, nucl ag (ebna)(igg) >5.00 +, cyto ab (igg) 3.91 +
Possible exposure: Igg positive antibodies which you have, indicate a past infection and not recent i.e. Active. Positive i gm antibodies usually indicate current infection. This means you may be have been exposed to mono in the past, the debate still goes on whether there's any correlation between this and chronic fatigue syndrome as many patients who have positive igg or igm do not have chronic fatigue symptoms. ...Read more