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Pseudochol deficient: Pseudocholinesterase deficiency is an inherited enzyme abnormality that results in abnormally slow breakdown of drugs such as succinylcholine (typically used during anesthesia for surgery). The drug thus takes lower to break down and causes a longer than expected effect - sometimes lasting hours as opposed to minutes. ...Read more
Why do you ask?: Or ... "What are Organophosphates?" if you're playing Jeopardy. ...Read more
Here are some: Perhaps you are thinking of Myasthenia Gravis, where the acetylcholine fails due to immune damage of the neuromuscular junction, but botulism and black widow spider bites also affect acetylcholine transmission, and this chemical drops in Alzheimer's and Parkinsonian dementias. ...Read more
Enzyme Blocker: Mutliple drugs are available to block the effects of this enzyme which breaks down acetylcholine - essential for muscle movement along with many other functions. Used for myasthenia gravis, alzheimers, glaucoma, etc. Drugs such as edrophonium, neostigmine , physostigmine, pyridostigmine, etc. ...Read more
Enzymolology: That's an interesting question. Many enzymes are capable of processing more than one substrate, but they are not very efficient with multiple substrates. A good example is alcohol dehydrogenase. Acetylcholinesterase is essentially a "one-substrate" enzyme based on its biochemical properties. ...Read more
Drug out of China: Huperzine a might have some benefit similar to drugs such as donepezil, rivastigmine, or galantamine, as it too, is a cholinesterase inhibitor. Has received hype in the alternative literature, due to lack of branding and commercial ownership, but it is unlikely to be any better than the above prescription meds. Do not waste money pursuing the "chinese aricept". ...Read more
If acetylcholinesterase is not present to remove acetylcholine, the muscle is in contraction. What is the name of the disorder/disease?
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