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Doctor insights on: Acetylcholine Receptor Blocking Ab

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Tested for acetylcholine receptor ab panel; both binding and blocking were 0, but modulating came back at 10. Does this mean I have myasthenia gravis?

Tested for acetylcholine receptor ab panel; both binding and blocking were 0, but modulating came back at 10. Does this mean I have myasthenia gravis?

AchRAntibodies: Binding antibodies are the most sensitive--they are positive in over 80% of ms patients. Blocking antibodies are positive in about half. Modulating antibodies alone don't support the diagnosis and have a lot oof false positives. In summary the achreceptor antibody panel does not suggest that ou have ms>. ...Read more

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Receptor (Definition)

An organ, cell or molecule that accepts an outside signal and causes an internal change. Eyes receive light, touch receptors send messages to the brain when stimulated by pressure and estrogen receptors bind Estradiol causing responses of normal breast, ovary and uterus cells to rising and falling levels of the female steroid hormones. Most of the time "receptor" refers to one ...Read more


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I failed my qsart test what is the next step and what could this mean? Acetylcholine receptor ab 0.00 nmol/l <=0.02 12/12/2012 and my antibody norma

I failed my qsart test what is the next step and what could this mean?	Acetylcholine receptor ab	0.00	nmol/l	<=0.02	12/12/2012
and my antibody  norma

QSART: Quantitative sudomotor autonomic reflex testing (qsart) is used to diagnose: painful small fiber neuropathy when nerve conduction test results are normal; disturbances of the autonomic nervous system, which controls the sweat glands, heart, gastrointestinal tract, other organs, and blood pressure; complex regional pain syndrome or reflex sympathetic dystrophy. A discussion with ur neurologist next. ...Read more

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What are acetylcholine receptor antagonists and what are they used for?

What are acetylcholine receptor antagonists and what are they used for?

Neuromusculat ransmi: Acetylcholine is an import neuromuscular transmitter that controls muscle functions and bodily and organ movements inside. So using antagonists can block these processes and cause trouble especially with the function of our smooth muscles of the bowel(constipation)bladder(urine retention) and eyes(blurred vision). ...Read more

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What other diseases can give the same symptoms as systemic myasthenia gravis when antibodies against the acetylcholine receptor are negative?

What other diseases can give the same symptoms as systemic myasthenia gravis when antibodies against the acetylcholine receptor are negative?

Anti-titin: There is a second type of antibody that is a perfect mimic. Eaton-Lambert antibodies are worth checking if you smoke. You may also be weak for other reasons, of if life's difficult, that itself can make you floppy and feel like you are getting MG. ...Read more

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What do acetylcholine receptors agonists do and what are they used for?

What do acetylcholine receptors agonists do and what are they used for?

different things: Agonists stimulate receptors while antagonists inhibit them. Most often we use the antagonist drugs in treating different diseases. However, those conditions that decrease sputum, sweat or tear production are sometimes treated with an agonist . Pilocarpine (an agonist) is used to treat glaucoma but by a different mechanism as mentioned above. ...Read more

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Do you know if acetylcholine is considered an agonist for the cholinergic receptors?

Do you know if acetylcholine is considered an agonist for the cholinergic receptors?

Terminology: Why are cholinergic receptors called cholinergic receptors? You can apply acetyl choline to cholinergic receptors and see the physiologic changes. ...Read more

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Can you tell me in myasthenia gravis why do you give an acetylcholine esterase inhibitor instead of a direct receptor agonist?

Because...: If you provide an agonist your muscles will contract continually. The acetylcholine esterase inhibitor prolongs the life of acetylcholine released naturally from your motor nerves so you only have muscle contraction when your brain orders it. ...Read more

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I read that there are nmda-like receptors in the epidermis. Would the anti-nmda ab test show antibodies to receptors in skin?

I read that there are nmda-like receptors in the epidermis.  Would the anti-nmda ab test show antibodies to receptors in skin?

No : Classically the nmda receptors are in the nervous system and associated with neurologic disease. There are tiny nerve fibers in the skin that have the receptor, not the skin itself, what importance this has in human disease is unknown, but some medical scientists think drugs which act on them may be useful in pain control some day. ...Read more

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Does geodon (ziprasidone) decrease motivation because of blocking of dopamine receptors?

Does geodon (ziprasidone) decrease motivation because of blocking of dopamine receptors?

Possible: You may be feeling decreased motivation due to the illness you are being treated for, or as a side effect of the medication. Side effects can wear off so if not too detrimental, give it some time. It is important to always let your treating physician know how you are feeling. Take good care of yourself while you heal. ...Read more