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Doctor insights on: Acetylcholine Receptor Antibody

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Is the anti-nmda receptor autoantibody considered a paraneoplastic autoantibody?

Anti NMDA ab: It can be found on anti-nmda receptor encephalitis -which can be related to tumor of the ovaries. Anti nmda can be also found on other conditions such as schizophrenia and narcolepsy associated with psychotic features. Please discuss further with your neurologist and your pmd. ...Read more

Receptor (Definition)

An organ, cell or molecule that accepts an outside signal and causes an internal change. Eyes receive light, touch receptors send messages to the brain when stimulated by pressure and estrogen receptors bind Estradiol causing responses of normal breast, ovary and uterus cells to rising and falling levels of the female steroid hormones. Most of the time "receptor" refers to one ...Read more


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Can autoantibodies against glutamate receptors cause glutamate metabolism disorders?

Can autoantibodies against glutamate receptors cause glutamate metabolism disorders?

Yes. Great Question!: The Amino Acid glutamate plays a central role in nitrogen metabolism & participates in multiple biochemical pathways. Disease examples: autoantibodies to the glutamate receptor kill neurons via activation of the receptor ion channel. Anti-nmda receptor encephalitis is a treatment-responsive inflammatory encephalopathic autoimmune disease associated with anti-nmda receptor antibodies. ...Read more

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Can autoantibodies against glutamine synthetase and/or glutamate dehydrogenase cause glutamate metabolism disorders?

Can autoantibodies against glutamine synthetase and/or glutamate dehydrogenase cause glutamate metabolism disorders?

Still searching: Glutamine synthase is part of the glutamine synthetase family. Ammonia incorporation in animals occurs through the actions of glutamate dehydrogenase and glutamine synthase. Glutamate plays the central role in mammalian nitrogen flow, serving as both a nitrogen donor and nitrogen acceptor. I am unble to find references in my search so far as to autoantibodies to these but see comment. ...Read more

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Discuss monoclonal antibody production?

Discuss monoclonal antibody production?

Monospecific Ab.: Monoclonal antibodies are those that are produced by the identical immune cells that are descended from the same parent cell. They produce anitibodies that bind to only one epitope or site on an antigen. This means that they are monospecific. This makes them useful in things like research because they can isolate a strain purely and completely. ...Read more

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Is antithyroglobulin antibody test the same as thyroglobulin antibody test?

Is antithyroglobulin antibody test the same as thyroglobulin antibody test?

Yes: Both address presence of antibody to the rhyroglobulin molecule made by thyroid gland. See this site for more info. http://www.nlm.nih.gov/medlineplus/ency/article/003557.htm. ...Read more

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Is there a test to detect autoantibodies against peripheral glutamate receptors (glutamate receptors in peripheral tissues)...?

Is there a test to detect autoantibodies against peripheral glutamate receptors (glutamate receptors in peripheral tissues)...?

Possibly, not likely: There may be a possible tests to detect antibodies to the peripheral tissues, but it would likely require a biopsy. It would be very difficult to differentiate antibodies also because they would be in present in your entire body rather than just in one location. ...Read more

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What would cause an intolerance to glutamic acid? Gad autoantibodies? Gad deficiency? Glutamate receptor autoantibodies(anti-nmda, anti-ampa)?

What would cause an intolerance to glutamic acid? Gad autoantibodies?  Gad deficiency?  Glutamate receptor autoantibodies(anti-nmda, anti-ampa)?

None of the above.: Msg - ubiquitous Amino Acid and major excitatory neurotransmitter in brain. Studied extensively. Does not cause allergy or intolerance except at high dose and only then in susceptible persons when given in large doses without food. See fda, j. Nutrition, food chem and toxicology, etc. ...Read more

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Is there a test to detect autoantibodies against metabotropic glutamate receptors?

Is there a test to detect autoantibodies against metabotropic glutamate receptors?

You asked for it: Yes, there is. It's for research. Abs to the mGluR1 subunit of metabotropic Glu receptor 1 have been found in small groups of ataxia pts. They're also detected in nonimmunological neurological diseases eg stroke & trauma but these may be epiphenomena (due to spillage of cell contents outside the blood-brain barrier). If you're concerned, my advice is: Find something else to worry about. ...Read more

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Elevated EBV ab VCA IgG <8 and EBV nucleaer antigen ab IgG test 4.2. & anti-dna(ss)igg ab qn ( 119)& c react protien(5.6) what are implications?

Elevated EBV ab VCA IgG <8 and EBV nucleaer antigen  ab IgG test 4.2. & anti-dna(ss)igg ab qn ( 119)& c react protien(5.6)  what are implications?

Nothing.: Ebv antibodies indicate you had a previous infection, but not active. The c-reactive protein needs a units indicator - that is either normal or somewhat elevated. The anti ss dna is extremely nonspecific and very rarely indicated; I have no idea why that was ordered, discuss with your doctor. ...Read more

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What are GABA antagonists that lead to gaba-a receptor up-regulation?

What are GABA antagonists that lead to gaba-a receptor up-regulation?

Not safe: GABA antagonists are not routinely prescribed for GABA A receptor upregulation. The main one flumazenil (clonazepam) is used for overdoses from benzodiazepines in an ER setting. It may cause withdrawal seizures. Your best bet is to detox and enter a drug tx program for alcohol or sedative-hypnotic dependence issues. ...Read more

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Is stanozolol a beta receptor antagonist?

Is stanozolol a beta receptor antagonist?

Stanozolol: Stanozolol is a synthetic anabolic steroid derived from testosterone. It is banned from use in athletes but has a role in some medical conditions. Please look up stanozolol in Wikipedia on the internet. ...Read more

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Will a GABA antagonist binded to the GABA receptors sites ever unbind ?

Yes.: Receptors are bound, unbound and replaced all the time. ...Read more

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Describe polyclonal and monoclonal antibody production?

Cells vs, animals: A monoclonal antibody is produced by in-vitro manipulation by expoanding a single cell making a desired antibody. Polyclonal antibodies are usually derived from immunizing an animal and colletcting its blood/serum containing the antibody. Polyclonal antibodies are a mixture of a large number of different cells. ...Read more

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Can working with NMDA receptor antagonists cause psychosis?

Can working with NMDA receptor antagonists cause psychosis?

Working with?: The nmda receptor agents are a new and exciting arae in the treatment of psychotic disorders. When added to current therapies it can help. But these effects must be monitored by your doctor and therapist and family (if available to give feedback). Laboratory and industrial exposure may cause untoward CNS activation in workers. Most labs have saftey standards for safe use of chemical process. ...Read more

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Are brca hormone receptors?

Are brca hormone receptors?

No: Brca genes are important in repairing damaged dna. Mutations in these genes allow defective dna to replicate and turn the cells with defective dna into turmors. ...Read more

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Does triavil block dopamine receptors in the central nervous system?

Does triavil block dopamine receptors in the central nervous system?

Yes: Triavil is an old medicine that is not often used anymore. It's a combination of Amitriptyline and perphenazine. The latter is a neuroleptic (antipsychotic) medication that mainly acts by blocking Dopamine receptors in the brain. ...Read more

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Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more