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Doctor insights on: Acetazolamide Carbonic Anhydrase Inhibitor

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Is it true Thiamine is a carbonic anhydrase inhibitor (seen a couple of studies) and if so, could it be helpful in idiopathic intracranial hypertensio?

Is it true Thiamine is a carbonic anhydrase inhibitor (seen a couple of studies) and if so, could it be helpful in idiopathic intracranial hypertensio?

Maybe: The science is a bit sketchy, and mostly Internet based, which does cast suspicion on validity, but seems to be some possible mechanisms by thiamine on CO2 metabolism. If pseudo tumor is present, would certainly try Diamox (acetazolamide) or glycerol, but would not hurt to add thiamine (vitamin B-1), but would not use B-1 exclusively, as I am not convinced of its efficacy. ...Read more

Dr. Siviero Agazzi
178 doctors shared insights

Acetazolamide (Definition)

Acetazolamide is a carbonic anhydrase inhibitor which is a kind of water pill or diuretic (heart ...Read more


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I've read studies that high doses of thiamine can be as effective as acetezolomide in terms of Carbonic anhydrase inhibitor. True? I have IIH.

Maybe so: I can confirm that I have also read studies that suggest that thiamine is a significant carbonic anhydrase inhibitor. Considering the seriousness of the condition that you are treating, you should probably stick with the known effect of diamox (acetazolamide). However, you could discuss this with your treating physician. ...Read more

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Will latisse have interactions with other medications i take? I'm on an oral carbonic anhydrase inhibitor for glaucoma. Will using latisse have any adverse affect or interaction? Are there other medications or ointments that might be a problem if used tog

Will latisse have interactions with other medications i take? I'm on an oral carbonic anhydrase inhibitor for glaucoma. Will using latisse have any adverse affect or interaction? Are there other medications or ointments that might be a problem if used tog

Should : Should not have any adverse affect but may result in an even lower eye pressure. You may see if you eye doctor can switch you form the carbonic anydrase inhibitor to Lumigan eye drops which will help the glaucoma and your lashes at the same time (lumigan and Latisse (bimatoprost) are the same medicine). ...Read more

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Are there are Foods/minerals/supplements which are natural Carbonic Anhydrase Inhibitors?

Are there are Foods/minerals/supplements which are natural Carbonic Anhydrase Inhibitors?

Yes: Carbonic anhydrase (CA) is an enzyme which converts carbon dioxide (CO2) to bicarbonate (sodium bicarbonate) and a proton (hydrogen ion.) Resveratrol, catechin, silymarin, and curcumin are natural products known as polyphenols. Resveratrol comes from red wine. Catechin is found in tea. Silymarin is an extract of milk thistle. ...Read more

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Has anyone tried carbonic anhydrase inhibitors?

Has anyone tried carbonic anhydrase inhibitors?

Helpful drug: Carbonic anhydrase inhibitors (cai) are used mainly to treat two conditions: glaucoma and altitude sickness. They are useful in both conditions and actually mandatory for high altitude climbing. There are side effects from chronic use, mainly kidney stones. Discuss this will your doctor if you think you need them. ...Read more

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Has anyone with paramyotonia congenita and hyperkalemic periodic paralysis used carbonic anhydrase inhibitors?

Has anyone with paramyotonia congenita and hyperkalemic periodic paralysis used carbonic anhydrase inhibitors?

Channelopathies: Your question is interesting. Here is a reference that answers it: channelopathies. Moxley iii rt. Curr treat options neurol. 2000 jan;2(1):31-47. Pmid: 11096735 [pubmed - as supplied by publisher] in short, yes. Longer answer, in some situations it can help, in others, it can make matters worse. The reasons are not understood. Go to pubmed and search for that article, then read the abstract. ...Read more

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I have paramyotonia congenita and hyperkalemic periodic paralysis and want to try carbonic anhydrase inhibitors?

Then by all means: speak to your neurologist. We all have to learn about these condition, frankly, they are heavily tested on our board exams; however, rarely actually seen. I'd consider seeing a neurologist with expertise in neuromuscular disorders. ...Read more

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Are there natural sources of Carbonic Anhydrase Inhibitors? I've read pomegranate, milk thistle and turmeric are? True?

Are there natural sources of Carbonic Anhydrase Inhibitors? I've read pomegranate, milk thistle and turmeric are? True?

Verify your sources: Sadly, despite a huge level of interest in the medicinal properties of foods, or maybe because of it, there is an enormous amount of false, half true, or exaggerated information on the internet. In regards to CAI in Pomegranate, I found a review article in an Iranian pharmacy journal that cited 2 chemistry review articles, neither of which makes any mention of Pomegranate whatsoever. ...Read more

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I have Pseudotumor Cerebri. I've read Pomegranate, milk thistle, turmeric, capsaicin all hold Carbonic Anhydrase Inhibitors naturally. Is this true?

Use with care: I can confirm that pomegranate and turmeric contain some carbonic anhydrase inhibitor activity. However, these do not have enough of this to be clinically useful. It is much more straightforward to take a small dose of diamox (acetazolamide) instead. Although it does not work for everyone with PTC, it helps many. The side effects would be the same if the medicine dose was the same. ...Read more

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I want to know what is the function of carbonic anhydrase in the brain.

I want to know what is the function of carbonic anhydrase in the brain.

Acid-base regulation: Carbonic anhydrase (CA) is found throughout the brain. It is concentrated in the areas producing cerebro-spinal fluid and helps maintain that pressure. But all cells have this important enzyme involved in keeping the acid-base balance of the brain and body. ...Read more

Diamox (Definition)

Diamox is a carbonic anhydrase inhibitor which is a kind of water pill or diuretic (heart ...Read more


Dr. M. Hytham Beck
6 doctors shared insights

Carbonic Anhydrase Inhibitor (Definition)

Carbonic anhydrase inhibitors are a kind of water pill or diuretic (heart ...Read more