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Doctor insights on: Acetazolamide Carbonic Anhydrase Inhibitor

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Is it true Thiamine is a carbonic anhydrase inhibitor (seen a couple of studies) and if so, could it be helpful in idiopathic intracranial hypertensio?

Is it true Thiamine is a carbonic anhydrase inhibitor (seen a couple of studies) and if so, could it be helpful in idiopathic intracranial hypertensio?

Maybe: The science is a bit sketchy, and mostly Internet based, which does cast suspicion on validity, but seems to be some possible mechanisms by thiamine on CO2 metabolism. If pseudo tumor is present, would certainly try Diamox (acetazolamide) or glycerol, but would not hurt to add thiamine (vitamin B-1), but would not use B-1 exclusively, as I am not convinced of its efficacy. ...Read more

Dr. Siviero Agazzi
180 doctors shared insights

Acetazolamide (Definition)

Acetazolamide is a carbonic anhydrase inhibitor which is a kind of water pill or diuretic (heart ...Read more


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I've read studies that high doses of thiamine can be as effective as acetezolomide in terms of Carbonic anhydrase inhibitor. True? I have IIH.

Maybe so: I can confirm that I have also read studies that suggest that thiamine is a significant carbonic anhydrase inhibitor. Considering the seriousness of the condition that you are treating, you should probably stick with the known effect of diamox (acetazolamide). However, you could discuss this with your treating physician. ...Read more

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Will latisse have interactions with other medications i take? I'm on an oral carbonic anhydrase inhibitor for glaucoma. Will using latisse have any adverse affect or interaction? Are there other medications or ointments that might be a problem if used tog

Will latisse have interactions with other medications i take? I'm on an oral carbonic anhydrase inhibitor for glaucoma. Will using latisse have any adverse affect or interaction? Are there other medications or ointments that might be a problem if used tog

Should : Should not have any adverse affect but may result in an even lower eye pressure. You may see if you eye doctor can switch you form the carbonic anydrase inhibitor to Lumigan eye drops which will help the glaucoma and your lashes at the same time (lumigan and Latisse (bimatoprost) are the same medicine). ...Read more

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Are there are Foods/minerals/supplements which are natural Carbonic Anhydrase Inhibitors?

Are there are Foods/minerals/supplements which are natural Carbonic Anhydrase Inhibitors?

Yes: Carbonic anhydrase (CA) is an enzyme which converts carbon dioxide (CO2) to bicarbonate (sodium bicarbonate) and a proton (hydrogen ion.) Resveratrol, catechin, silymarin, and curcumin are natural products known as polyphenols. Resveratrol comes from red wine. Catechin is found in tea. Silymarin is an extract of milk thistle. ...Read more

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Has anyone tried carbonic anhydrase inhibitors?

Has anyone tried carbonic anhydrase inhibitors?

Helpful drug: Carbonic anhydrase inhibitors (cai) are used mainly to treat two conditions: glaucoma and altitude sickness. They are useful in both conditions and actually mandatory for high altitude climbing. There are side effects from chronic use, mainly kidney stones. Discuss this will your doctor if you think you need them. ...Read more

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Has anyone with paramyotonia congenita and hyperkalemic periodic paralysis used carbonic anhydrase inhibitors?

Has anyone with paramyotonia congenita and hyperkalemic periodic paralysis used carbonic anhydrase inhibitors?

Channelopathies: Your question is interesting. Here is a reference that answers it: channelopathies. Moxley iii rt. Curr treat options neurol. 2000 jan;2(1):31-47. Pmid: 11096735 [pubmed - as supplied by publisher] in short, yes. Longer answer, in some situations it can help, in others, it can make matters worse. The reasons are not understood. Go to pubmed and search for that article, then read the abstract. ...Read more

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I have paramyotonia congenita and hyperkalemic periodic paralysis and want to try carbonic anhydrase inhibitors?

Then by all means: speak to your neurologist. We all have to learn about these condition, frankly, they are heavily tested on our board exams; however, rarely actually seen. I'd consider seeing a neurologist with expertise in neuromuscular disorders. ...Read more

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Are there natural sources of Carbonic Anhydrase Inhibitors? I've read pomegranate, milk thistle and turmeric are? True?

Are there natural sources of Carbonic Anhydrase Inhibitors? I've read pomegranate, milk thistle and turmeric are? True?

Verify your sources: Sadly, despite a huge level of interest in the medicinal properties of foods, or maybe because of it, there is an enormous amount of false, half true, or exaggerated information on the internet. In regards to CAI in Pomegranate, I found a review article in an Iranian pharmacy journal that cited 2 chemistry review articles, neither of which makes any mention of Pomegranate whatsoever. ...Read more

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I have Pseudotumor Cerebri. I've read Pomegranate, milk thistle, turmeric, capsaicin all hold Carbonic Anhydrase Inhibitors naturally. Is this true?

Use with care: I can confirm that pomegranate and turmeric contain some carbonic anhydrase inhibitor activity. However, these do not have enough of this to be clinically useful. It is much more straightforward to take a small dose of diamox (acetazolamide) instead. Although it does not work for everyone with PTC, it helps many. The side effects would be the same if the medicine dose was the same. ...Read more

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I want to know what is the function of carbonic anhydrase in the brain.

I want to know what is the function of carbonic anhydrase in the brain.

Acid-base regulation: Carbonic anhydrase (CA) is found throughout the brain. It is concentrated in the areas producing cerebro-spinal fluid and helps maintain that pressure. But all cells have this important enzyme involved in keeping the acid-base balance of the brain and body. ...Read more

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Is there a better combination for PTC instead of diamox, topamax, and keppra (levetiracetam)? And R we close to a cure?

Is there a better combination for PTC instead of diamox, topamax, and keppra (levetiracetam)? And R we close to a cure?

We have the cure: There is no cure, & we know the cure. Obesity is the major risk factor for PTC. Only 1 of my PTC pts has not been obese and her weight has to stay below 138 lb or the headaches come back. The arachnoid villi that reabsorb the CSF normalize when weight is lost; the abnormality appears in obesity. So for the foreseeable future, the "cure" for PTC will be weight loss. ...Read more

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Changes in taste with diamox/acetazolamide?

Changes in taste with diamox/acetazolamide?

The Most Common:: Carbonated drinks taste awful for many on Diamox (acetazolamide) which can be a surprise if you are a dedicated soda pop fan; beer becomes dreadful as well. Foods may also become either bitter or oddly bland though this side effect sometimes fades with time. Others might note a metallic taste in their mouth. A few complain of nausea and loss of appetite. ...Read more

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What kind of pain medication can I take with acetazolamide?

Almost any...: Whatever pain medication is appropriate for the painful disorder that you are currently experiencing, is likely to be safe with the drug you are asking about., as always, check with your doc. ...Read more

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What effect does Diamox (acetazolamide) have on your vision?

Lowers pressure: Diamox (acetazolamide) is a terrific agent for lowering the internal pressure of the eye. This will only have an effect on the vision if over the long run the vision would have been threatened by elevated pressure when Diamox (acetazolamide) could have normalized it. In the short run, no effects will be symptomatic. ...Read more

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I have been on acetazolamide for 2 weeks now and I am still on it ?

I have been on acetazolamide for 2 weeks now and I am still on it ?

Treatment?: Depends on what you are being treated for. I.E. Eye pressure, headaches, pseudotumor, altitude sickness, CSF issues, seizures, diuresis, etc. And if it is working or if you have any side effects. ...Read more

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Does acetazolamide have dangerous side effects?

Does acetazolamide have dangerous side effects?

It can: See labeling on diamox (acetazolamide). Depends on dosage, how you metabolize it, coexisting medications, if you are sensitive to it, drug interactions, etc. ...Read more

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Could an overdose of Diamox (acetazolamide) pills kill you?

Could an overdose of Diamox (acetazolamide) pills kill you?

Unlikely: Although serious dehydration and salt depletion has occurred requiring hospitalization and supportive care, overdose of Diamox (acetazolamide) is very survivable. The half life of Diamox (acetazolamide) is 9 hours and is cleared by the kidneys. Usually fluid support is given and often potassium while maintaining the body's in acid base balance. As Diamox (acetazolamide) clears out, the person gradually recovers--usually without any lasting harm. ...Read more

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What is the mechanism of diuresis caused by acetazolamide?

Acetazolamide: As a carbonic andydrase inhibitor, acetazolamide decreases the rate of carbonic acid and hydrogen ion production of the kidney, this increases the excretion of solutes and the rate of urinary output. ...Read more

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What kind of pain reliever can I take when on acetazolamide?

TYLENOL (acetaminophen)??!!: If you are taking it due to seizures it will be hard to give you advice. Your doctir is the best source. However, tyleneol is always a safe alternative. ...Read more

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Is acetazolamide the treatment for acute glaucoma attack?

Partly: Acute glaucoma is due to an anatomical eye issue most common in older adults who are hyperopic. Their internal fluid drainage is blocked by the iris. The goal is to lower the pressure and move the iris out of the way. This is done with several types of eyedrops and acetazolamide helps to lower the pressure. These folks will eventually have a laser opening made in their iris to prevent attacks. ...Read more

Dr. Gregory Moneta
83 doctors shared insights

Diamox (Definition)

Diamox is a carbonic anhydrase inhibitor which is a kind of water pill or diuretic (heart ...Read more


Dr. Corey Clay
6 doctors shared insights

Carbonic Anhydrase Inhibitor (Definition)

Carbonic anhydrase inhibitors are a kind of water pill or diuretic (heart ...Read more