Doctor insights on:
Acetazolamide Carbonic Anhydrase Inhibitor
Is it true Thiamine is a carbonic anhydrase inhibitor (seen a couple of studies) and if so, could it be helpful in idiopathic intracranial hypertensio?
Maybe: The science is a bit sketchy, and mostly Internet based, which does cast suspicion on validity, but seems to be some possible mechanisms by thiamine on CO2 metabolism. If pseudo tumor is present, would certainly try Diamox (acetazolamide) or glycerol, but would not hurt to add thiamine (vitamin B-1), but would not use B-1 exclusively, as I am not convinced of its efficacy. ...Read more
I've read studies that high doses of thiamine can be as effective as acetezolomide in terms of Carbonic anhydrase inhibitor. True? I have IIH.
Maybe so: I can confirm that I have also read studies that suggest that thiamine is a significant carbonic anhydrase inhibitor. Considering the seriousness of the condition that you are treating, you should probably stick with the known effect of diamox (acetazolamide). However, you could discuss this with your treating physician. ...Read more
Will latisse have interactions with other medications i take? I'm on an oral carbonic anhydrase inhibitor for glaucoma. Will using latisse have any adverse affect or interaction? Are there other medications or ointments that might be a problem if used tog
Should : Should not have any adverse affect but may result in an even lower eye pressure. You may see if you eye doctor can switch you form the carbonic anydrase inhibitor to Lumigan eye drops which will help the glaucoma and your lashes at the same time (lumigan and Latisse (bimatoprost) are the same medicine). ...Read moreSee 3 more doctor answers
Yes: Carbonic anhydrase (CA) is an enzyme which converts carbon dioxide (CO2) to bicarbonate (sodium bicarbonate) and a proton (hydrogen ion.) Resveratrol, catechin, silymarin, and curcumin are natural products known as polyphenols. Resveratrol comes from red wine. Catechin is found in tea. Silymarin is an extract of milk thistle. ...Read more
Helpful drug: Carbonic anhydrase inhibitors (cai) are used mainly to treat two conditions: glaucoma and altitude sickness. They are useful in both conditions and actually mandatory for high altitude climbing. There are side effects from chronic use, mainly kidney stones. Discuss this will your doctor if you think you need them. ...Read more
Has anyone with paramyotonia congenita and hyperkalemic periodic paralysis used carbonic anhydrase inhibitors?
Channelopathies: Your question is interesting. Here is a reference that answers it: channelopathies. Moxley iii rt. Curr treat options neurol. 2000 jan;2(1):31-47. Pmid: 11096735 [pubmed - as supplied by publisher] in short, yes. Longer answer, in some situations it can help, in others, it can make matters worse. The reasons are not understood. Go to pubmed and search for that article, then read the abstract. ...Read more
I have paramyotonia congenita and hyperkalemic periodic paralysis and want to try carbonic anhydrase inhibitors?
Are there natural sources of Carbonic Anhydrase Inhibitors? I've read pomegranate, milk thistle and turmeric are? True?
Verify your sources: Sadly, despite a huge level of interest in the medicinal properties of foods, or maybe because of it, there is an enormous amount of false, half true, or exaggerated information on the internet. In regards to CAI in Pomegranate, I found a review article in an Iranian pharmacy journal that cited 2 chemistry review articles, neither of which makes any mention of Pomegranate whatsoever. ...Read more
I have Pseudotumor Cerebri. I've read Pomegranate, milk thistle, turmeric, capsaicin all hold Carbonic Anhydrase Inhibitors naturally. Is this true?
Use with care: I can confirm that pomegranate and turmeric contain some carbonic anhydrase inhibitor activity. However, these do not have enough of this to be clinically useful. It is much more straightforward to take a small dose of diamox (acetazolamide) instead. Although it does not work for everyone with PTC, it helps many. The side effects would be the same if the medicine dose was the same. ...Read more
Is there a better combination for PTC instead of diamox, topamax, and keppra (levetiracetam)? And R we close to a cure?
We have the cure: There is no cure, & we know the cure. Obesity is the major risk factor for PTC. Only 1 of my PTC pts has not been obese and her weight has to stay below 138 lb or the headaches come back. The arachnoid villi that reabsorb the CSF normalize when weight is lost; the abnormality appears in obesity. So for the foreseeable future, the "cure" for PTC will be weight loss. ...Read moreSee 1 more doctor answer
The Most Common:: Carbonated drinks taste awful for many on Diamox (acetazolamide) which can be a surprise if you are a dedicated soda pop fan; beer becomes dreadful as well. Foods may also become either bitter or oddly bland though this side effect sometimes fades with time. Others might note a metallic taste in their mouth. A few complain of nausea and loss of appetite. ...Read moreSee 1 more doctor answer
Lowers pressure: Diamox (acetazolamide) is a terrific agent for lowering the internal pressure of the eye. This will only have an effect on the vision if over the long run the vision would have been threatened by elevated pressure when Diamox (acetazolamide) could have normalized it. In the short run, no effects will be symptomatic. ...Read more
Unlikely: Although serious dehydration and salt depletion has occurred requiring hospitalization and supportive care, overdose of Diamox (acetazolamide) is very survivable. The half life of Diamox (acetazolamide) is 9 hours and is cleared by the kidneys. Usually fluid support is given and often potassium while maintaining the body's in acid base balance. As Diamox (acetazolamide) clears out, the person gradually recovers--usually without any lasting harm. ...Read more
TYLENOL (acetaminophen)??!!: If you are taking it due to seizures it will be hard to give you advice. Your doctir is the best source. However, tyleneol is always a safe alternative. ...Read more
Partly: Acute glaucoma is due to an anatomical eye issue most common in older adults who are hyperopic. Their internal fluid drainage is blocked by the iris. The goal is to lower the pressure and move the iris out of the way. This is done with several types of eyedrops and acetazolamide helps to lower the pressure. These folks will eventually have a laser opening made in their iris to prevent attacks. ...Read more
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