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Doctor insights on: Acetaminophen Metabolism Pathway

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What is the pathway tylenol (acetaminophen) takes through the body when administered through the rectum?

What is the pathway tylenol (acetaminophen) takes through the body when administered through the rectum?

Tylenol (acetaminophen) absorpion: hello ~ odd but interesting question. EXACTLY THE SAME ROUTE AS TAKING IT ORALLY, (or we wouldnt suggest taking it that way.) The rectal mucus membrane is exactly the same histologically as the mouth, so it gets absorbed thru the mmembrane, into the rectal veins into the internal iliac, into the coeliac vein and then the splenic vein AND portal v to liver. Metab in liver!Out in bile and duodenum.. ...Read more

Dr. Alvin Stein
2,080 doctors shared insights

Acetaminophen (Definition)

Acetaminophen (tylenol) is a non-steroidal anti-inflammatory which is a ...Read more


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What to do if I can't understand the pathway..so anyone can give any of metabolism bilirubin explanation?

What to do if I can't understand the pathway..so anyone can give any of metabolism bilirubin explanation?

Get help: The porphyria synthesis and breakdown pathways are elementary if you understand organic chemistry and its application to general metabolism, incomprehensible if you do not. Nobody here is going to be able to tell you anything more. Perhaps there has been a problem with sequencing the topics. ...Read more

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What is the pathway and role of vitamin B12 in metabolism/catabolism of phenylalanine and tyrosine? Thank you.

What is the pathway and role of vitamin B12 in metabolism/catabolism of phenylalanine and tyrosine? Thank you.

Nothing: In the normal child less than 50% of dietary phenylalanine is utilized for polypeptide ; protein synthesis. Most of that remaining is converted to tyrosine. All this takes place by enzymatic chemical activity and I am not aware that vitamin b-12 is involved. ...Read more

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Can i overdose on acetaminophen?

Can i overdose on acetaminophen?

Please do not.: If you are considering an overdose, please call 911 or your nearest emergency room. Do not harm yourself. You risk serious and irreversible damage to your body. ...Read more

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Can you get high on Acetaminophen?

Can you get high on Acetaminophen?

No: tylenol (acetaminophen) by itself should not have that effect. Tylenol (acetaminophen) can be harmful and even deadly if not taken appropriately though. ...Read more

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Can i take too much acetaminophen?

Can i take too much acetaminophen?

Yes: For a healthy individual, it is recommended to not use more than 3 grams in a 24 hour period. ...Read more

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What amount acetaminophen in a day?

What amount acetaminophen in a day?

Least amount...: ...necessary not to exceed 3000mg in a 24-hour period of time. Don't take it all at once either, because it won't be any more effective in mega-doses. Not the best pain med available over the counter, just useful for fevers. ...Read more

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What is the pathway of spinal fluid?

What is the pathway of spinal fluid?

See below: In short from choroid plexus to arachnaoid granulations. For more info consult this: http://www.sciencedirect.com/science/article/pii/S1879729611001013 ...Read more

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Is 2, 000mg of acetaminophen in one dose too much?

Is 2, 000mg of acetaminophen in one dose too much?

Don't do it again: This won't hurt or kill you, but you do need to show this helpful drug the respect it deserves. It's important to space the doses out so that you don't get sick. Up to 4000 mg/day is fine but you don't want to take even this much all at once -- you might overload the enzyme that processes it by the normal pathway. ...Read more

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Is it possible for me to overdose on acetaminophen?

Absolutely: This drug can be very dangerous if you take more than 4 grams in a day. Man OTC medicines contain it, so you may not know you're taking it-read the label! It can cause liver failure and is the main reason liver transplant in the US today. No joke-be careful. ...Read more

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Does acetaminophen make you drowsy?

Not usually : Not usually , if you take only acetaminophen, but sometimes this medicine come as part of other medications like tylenol#3 or 4 or vicodin, then will cause drowsiness. ...Read more

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Can someone be fatally allergic to acetaminophen?

Can someone be fatally allergic to acetaminophen?

Rare: Anaphylactic reactions to acetaminphen are rare, but can still occur, especially is someone is severely allergic to Aspirin and non steroidal antiinflammatory drugs. I principle, one can become allergic to any drug. ...Read more

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What are the consequences of acetaminophen overdose?

What are the consequences of acetaminophen overdose?

Liver damage: Acetamenophen can damage the liver. It can be mild and barely undetectable all the way to death. If you suspicion any problem with acetamenophen poisoning, please go to the er immediately! ...Read more

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Is it true pain relievers wont wrk w/o acetaminophen?

No: They're formulated with Acetaminophen for additive pain relieving effect since mechanism of action is different for both. ...Read more

Dr. Boris Ripa
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