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Doctor insights on: Acetaminophen And Your Liver

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Can you tell me how tylenol (acetaminophen) damage your liver?

Can you tell me how tylenol (acetaminophen) damage your liver?

Sure: The liver breaks down most of the drug into safe components. However, a small amount of Tylenol (acetaminophen) is metabolized into a harmful by-product called NAPQI (N-acetyl-p-benzoquinoneimine). When Tylenol (acetaminophen) is taken in normal doses, your body can quickly remove this toxic by-product in the urine. However, when the liver needs to metabolize a large amount of tylenol, (acetaminophen) NAPQI is overproduced and damages the liver ...Read more

Dr. Lynne Weixel
2 doctors shared insights

Liver (Definition)

This organ plays a major role in metabolism and has a number of functions in the body, including glycogen storage, decomposition of red blood cells, plasma protein synthesis, hormone production, and detoxification. It lies below the diaphragm in the abdominal-pelvic region of the abdomen. It produces bile, an alkaline compound which aids in digestion via the emulsification of ...Read more


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How many acetaminophen can you take without your liver shutting down?

How many acetaminophen can you take without your liver shutting down?

3 Grams a day: It is recommended not to take more than 3 grams a day. Avoid other hepatotoxic meds and alcohol while taking more than a gram a day of acetaminophen. ...Read more

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At what rate does acetaminophen damage liver?

At what rate does acetaminophen damage liver?

Tylenol (acetaminophen) Toxicity: For average healthy adult, daily dose should not exceed 4 grams. Toxicity can be nausea, vomiting, sweating in first 24 hours, then right upper quadrant or flank pain due to liver or kidney damage, then after few days there will be multiple organ damage, sepsis, cerebral edema & death. Damage from toxicity is prominent within 1 week if used in excess. ...Read more

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How much acetaminophen one can take without damaging the liver?

How much acetaminophen one can take without damaging the liver?

4gm: If you are otherwise healthy and don't have any pre-existing liver disease, it is recommended that no more than 4gm of Acetaminophen be consumed over any 24 hour time period. ...Read more

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How much acetaminophen can you take before severely injuring your liver?

How much acetaminophen can you take before severely injuring your liver?

Acetaminophen : The current maximum total dose over 24 hours is 4 grams (4, 000mg). There is the likelihood that this may be reduced to 3 grams (3, 000 mg) in the near future. ...Read more

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How many acetaminophen would cause liver damage?

How many acetaminophen would cause liver damage?

Eight plus: Most Acetaminophen pills are 500 mg. The generally accepted rule of thumb is that more than 4 grams (4000 mg) is likely to injure the liver. Thus a person should not exceed eight Acetaminophen pills per day. Less is even better. ...Read more

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Why is tylenol (acetaminophen) so damaging to the liver?

Why is tylenol (acetaminophen) so damaging to the liver?

Over-dose - NAPQI: Tylenol (acetaminophen) is metabolized by the liver with a by product called n-acetyl-p-benzoquinoneimine (napqi). Napqi damages hepatocytes (liver cells). If you take an over-dose of tylenol (acetaminophen) there is too much napqi to safely remove through urine. The napqi damages the liver. ...Read more

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What can I do to help my liver repair itself? (after acetaminophen overdose)

What can I do to help my liver repair itself? (after acetaminophen overdose)

Tylenol (acetaminophen) overdose: Not sure of the severity of your liver injury when you had tylenol (acetaminophen) overdose. However, your liver should be able to recover fully after that episode. In the mean time, i would avoid tylenol (acetaminophen), alcohol, or anything toxic to the liver. ...Read more

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What do the experts think, should my liver start dying if i took 20 tylenol extra strength acetaminophen?

What do the experts think, should my liver start dying if i took 20 tylenol extra strength acetaminophen?

All at once!: If you took this all at once this was very poor judgment and your liver needs to be checked now. Call 911 and get to E.R. ...Read more

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I took two different medicines that both contain Acetaminophen, should I be worried? It says it causes severe liver damage and I'm scared about that

I took two different medicines that both contain Acetaminophen, should I be worried? It says it causes severe liver damage and I'm scared about that

Great question but: ...HealthTap doctors are asked only to respond to questions from individuals >16 years old. Consider having an older relative re-pose the question or contact your physician with your concern. ...Read more

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Dr. Alvin Stein
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