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Doctor insights on: Accuracy Of Ca 125 Screening

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Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Likely, no: CA 125 is not recommended as a screening tool for ovarian cancer when used in risk-based stratification. Meaning, assuming that your mom or sister didn't get diagnosed with ovarian cancer. Normal for women with endometriosis to have elevated CA-125. It sounds like your doctor has done Ultrasound to evaluate ovaries as well. Your MD knows your history and risk, likely this CA-125 level is normal ...Read more

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Dr. Daniel Lebowitz
1 doctor shared a insight

Screening (Definition)

Examples are: colonoscopy for colon polyp or cancer; mammograms for breast lesions or cancer; psa a blood test that could indicate enlargement of cancerous prostate tissue; blood sugar or hemoglobin a!c for diabetes. Many think that scanning the whole body will pick up a cancer--in all likelihood, it will not. There also is no good blood test, yet, ...Read more


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I recently scored a 46 on a ca 125 screening and am afraid that i may have cancer. Is that a 'normal' range for someone with endodemetriosis?

I recently scored a 46 on a ca 125 screening and am afraid that i may have cancer. Is that a 'normal' range for someone with endodemetriosis?

Maybe.: Depends on who is doing the talking. Experts disagree on normals especially in that range. Could be normal. But i suspect that with a complex ovarian lesion and a mildly elevated ca125 that the next step is biopsy. ...Read more

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Hwbc & lrbc were detected. Can i ask my doctor for a cancer screening like a ca125? I'm h risk, the youngest person to have cancer in my fam age 30.

Forgive my frankness: Hwbc and lrbc are not standard medical abbreviations. In the era of lmao and bff, you need to clarify. If you mean low red blood cells, you have an anemia and need to have the reason found rather than go on a cancer chase. Ca-125 is a bad screen if your pelvic exam is normal -- do you want unnecessary surgery? Instead, consider a brca1 / brca2 check, perhaps p53 / other gene screens. ...Read more

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What if your ca125 test is 125?

What if your ca125 test is 125?

Not a lot: This test can be elevated for several reasons: heart failure, ovarian cancer, and multiple other causes. Without a diagnosis of ovarian cancer all it means is there are a lot of questions. This test should not be ordered without a diagnosis or a very high suspicion of ovarian cancer. Hope this helps. ...Read more

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What is the ca-125 test?

CA-125: Cancer antigen 125 (ca-125) is a protein found on the surface of many ovarian cancer cells. It also can be found in other cancers and in small amounts in normal tissue. A ca-125 test measures the amount of this protein in the blood and can be used as a tumor marker. ...Read more

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What causes my ca 125 to go up?

Many causes: It is commonly elevated in ovarian cancer. But it can go up from any reason which causes irritation of the peritoneal lining of your abdomen which includes some benign conditions too. It depends on the level and also if it is going up steadily or staying elevated but stable and not increasing. Your gynecologist can help you to sort it out. ...Read more

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What is the significance of ca-125?

Ovarian Cancer: It is a tumor marker for ovarian, endometrium, fallopian tube, lung, breast and gastrointestinal tract cancers. It is commonly used to follow ovarian cancer in response to therapeutic treatments and can be positive in nearly 80% of cases. It is not specific to cancer, however, and can be elevated in benign abdominal problems too such as endometriosis. ...Read more

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Could a high ca125 be due to pelvic adhesions?

No: Adhesions and ca-125 would be unrelated. An isolated elevation of ca-125 with no other clinical information or physical findings is of questionable importance. Would need to see a gynecologist for an evaluation. ...Read more

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Can a fibroid and a cyst come up on a ca 125 test?

Yes: Fibroids, benign cysts, endometriomas, and endometriosis can all result in a positive ca-125 test. Ca-125 is not a good screening test for ovarian cancer because there are so many causes of false positives. And furthermore, 50% of st 1 ovarian cancer may have a negative ca-125. Nonetheless, if you have a positive ca-125 and an ovarian cyst, it will probably need to be explored. ...Read more

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What is a good decrease in the ca-125 blood test numbers with chemo?

What is a good decrease in the ca-125 blood test numbers with chemo?

Depends: Best decrease is to normal values, less than 25. A good respond to chemo basically will show normal values that will stay normal. Any elevation of ca 125 after chemo may signal recurrence. ...Read more

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My ca-125 is positive.What does it mean? My right ovary forms cyst in ipotesi.

My ca-125 is positive.What does it mean? My right ovary forms cyst in ipotesi.

What's positive?: How high is it? Ca125 is not a test used to diagnose ovarian cancer but to follow its response to therapy. Many things, malignant or not, can make it go up. You are young for ovarian cancer but i would advise you follow up with your doctor and have a good chat about the implications of the test results. Ciao! ...Read more

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Need expert advice. After usg, my doctor asked me to test ca 125. I have 58. What does it mean?

Tumor marker: Research is ongoing to try to achieve earlier detection for ovarian cancer. CA125 is most commonly elevated with advanced stage ovarian cancer, but there can be false elevations as well. Please ask your doctor what it means in your case, but most times blood work needs to be correlated with imaging studies or the physical exam. ...Read more

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My ca 125 blood test result slightly elevated, with a different reading 3 times, what could cause this to happen?

My ca 125 blood test result slightly elevated, with a different reading 3 times, what could cause this to happen?

Many causes: The ca-125 blood test is very sensitive-- in many cases it is too sensitive. In certain cases, it can be a marker of certain types of cancer. But in other patients, a modestly elevated ca-125 is not alarming. Visit with your doctor to better understand the details of your case. ...Read more

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Where does ca125 originate?

In the peritoneal li: It arises from the irritation or growth of peritoneal lining cells. These cells also cover the ovaries. So ca 125 is often used as a test to screening for ovarian cancer. But it often raised in any conditions causing intra -abdominal irritation like in peritonitis. ...Read more

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What are the functions of ca125?

Part of cell surface: Ca125 is a component of mucin, mucous like material on the surface of cells that provides lubrication and is a barrier to foreign invaders. It is found on many different types of cells, including the female organs. It is shed from tumor cells in ovarian cancer, and therefore can be measured in blood as a tumor marker, but since ca125 is on many other kinds of cells, it is not specific. ...Read more

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What is the definition or description of: ca125?

CA125 Definition: Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast et al. In 1983. ...Read more

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How concerned should I be if my ca125 level was not ordered this year?

How concerned should I be if my ca125 level was not ordered this year?

None to minimal: If the ca-125 was going to be used simply as another blood test for example in a yearly physical, you should not be terribly concerned at all. My answer is different however, if you have a history of a disease such as ovarian cancer and that it should be checked. I also might order it if you have a strong family history of ovarian cancer for example. If not you should not be concerned. ...Read more

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Is 80.04 result of my ca 125 can be cured?

Cannot tell: More information is needed to recommend possibility of cure. Please re-ask the question with what diagnosis included and any previous treatment. ...Read more

Dr. Shari Jackson
126 doctors shared insights

Ca125 (Definition)

Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast ...Read more