Doctor insights on:
Black box warning?: Abraxane is a powerful drug for the treatment of some cancers. Like most chemotherapy meds, it can have serious side effects. See this description of how and when to use it, and when not to, including "Black Box warnings" here. https://medicalpolicies.amerigroup.com/medicalpolicies/guidelines/gl_pw_c189660.htm ...Read more
Chemotoxicity: ABRAXANE is an Injectable suspension of paclitaxel , a derivative of Taxol formulated as albumin-bound nanoparticles with a mean particle size of approximately 130 nanometers and sodium acetyltryptophanate . Toxicity of taxol and abraxane are similar and present with numbness, tingling, pain, or weakness in hands or feet; Sudden chest pain or discomfort, wheezing dry cough, Low WBC and fever. ...Read more
Diagnosed with stage 4 pan can. Treated w/Gemcitabine/abraxane combo. Pretreatment ca19-9 was 486. Now ca19-9 is in normal range. What does this mean?
Temporary control: Stage 4 pancreas cancer only be managed with chemo, that is Folfieri (FOLFOX+ Irinotecan). Following this Gemzar (gemcitabine) + Abraxane gives best control as noted by normal Ca19.9 used for monitoring Follow up with serum markers and PET/CAT essential since increase in Ca19.9 suggests need for experimental trial with immunotherapy. ...Read more
Not really: Abraxane is a derivative of Taxol. It is employed after recurrent or metastatic pancreas cancers have failed Gemzar (gemcitabine) adding about 8 wks to the overall survival in these patients. The drug,protein-bound paclitaxel is an injectable formulation of paclitaxel, It has almost the same extent of neuropathy. ...Read more
For chemo treatment, what is the difference between Carboplatin and Abraxane, why are they used at different intervals?
Different origins: Carboplatin is a derivative of the platinum class of drugs including oxaliplatin. Their target is DNA on the surface of the tumor with the purpose of destroying DNA function and is useful in an array of malignancies including breast, ovary, lung. Abraxane is a newer derivative of Taxol and has mostly employed along with or following Gemzar (gemcitabine) in pancreatic Ca. ...Read more
What does it mean the edges are fading on a tumor? 3b nsclc. 26 rounds of rad, 6 chemo. Going to more aggressive abraxane/carboplatin starting 3/3.
Tumor Border notes:
First, God bless you and your family for your fight. Keep up your spirits if you can.
Tumor border (and size) on CT can help us guess tumor activity but after XRT, fibrosis is hard to separate from viable cells. MRI and esp. PET may be better. These days with "biologic" treatments like Avastin, (bevacizumab) even these modalities may not be prognostic.
An HT oncologist may give different insights. ...Read more
Yes it is an option: The standard therapy for ovarian cancer initially is still a taxane (usually Taxol) and Carboplatin. However, Abraxane is an effective taxane down the line for recurrences, and is potentially less toxic. Avastin (bevacizumab) has been combined safely with Abraxane and the two may be helpful for recurrence management. But the question is a bit difficult to answer concretely because circumstances differ. ...Read more
After 39 rounds of radiation, starting full strength Abraxane/Carboplatin on 3/3. What are the side effects and is it effective for 3b nsclc?
Difficult to answer: In a limited space, the common side effects of Abraxane & Carboplatinum include nausea, vomiting, weakness, indigestion, diarrhea, mouth sores, headache, muscle or joint pain, numbness/tingling/burning of the hands/feet, dizziness, infections, anemia, hair loss, low blood counts making you prone to infection, bleeding. In Stage 3B, only about 8% of people survive 5 yrs, WITH radiation then chemo. ...Read more
Hello Doctors, my mum is undergoing chemo (Gemcitabine and Abraxane) for pancreatic cancer. Please advise what food & drinks to increase blood count.
I am on Abraxane. Tumor Markers started climbing after two months. Dr. Wants to add Avastin (bevacizumab). Is this a good option? Mets to abdomen, bones & Liver.
Not a good idea: Rising tumor markers often predict tumor progression. But this is soft evidence. A more definitive way to confirm lack of response(progression) is by means of repeating Imaging studies(like X-rays/CT scan or PET scan) and compare them with prior study. If the tumor size has increased, then Abraxane is no longer useful for you. Treatment should be changed . Adding Avastin (bevacizumab) would not help the situati ...Read more
There are none...: Even the strongest opiates only "take the edge off" for people in chronic pain. Meds are only one part of dealing with the pain. A useful tool, but pain is so necessary for survival that we are not "allowed" to monkey with it much. In acute pain, the transition from miserable to less miserable can be great. In chronic pain, it's just part of the plan. ...Read more
Sometimes: Sometimes they are. For the most part, expired drugs simply lose potency once past their expiration date. There are, however, some drugs that actually become harmful if taken after they expire. As such, it is best to throw out any medications you have after a year. ...Read more
ASPRIN: Actually no one has decided on 'safest'. Asprin has been around since before you were born and unless you take too much (yes, too much of anything isnt good) most people are okay with it. If the pain it too severe for asprin you need to know what causes it. Good diagnosis is called for. See the dr. ...Read more
Applies to skin: Topical just refers to how a medication is applied. In this case to the skin and is meant to treat local skin problems. Some meds are applied to the skin but are meant to be absorbed into the body in which case we use the term "transdermal" since it is meant to pass through the skin to affect the whole body. ...Read more
Why R you depressed?: If your depression is affecting your life and/or those around you and you have trouble dealing with it or not knowing how to etc..It is very reasonable to seek help, either from a therapist, your physician/nurse, or both. Psychotherapy may be adequate for some, others may need both meds (many choices, depending on your symptoms/needs) and therapy. Consult doc. Good luck. ...Read more
RSD, or: Complex regional pain syndrome can be difficult to treat and each patient needs to be treated differently. Opioid medications are definitely not the first option. Consider medications that affect nerve pain most, like neuromodulators such as gabapentin. Clonidine has been found to help some as well. Stellate ganglion blocks can be diagnostic/therapeutic. Consider topical ketamine creams as well. ...Read more
Antacid: An h2 blocker (like Pepcid (famotidine) or its generic) once or twice daily, provides relief for many after about a week. If this fails, a proton pump inhibitor (ppi--like Prilosec or its generic) will often work where h2's have failed. If both fail after at least one week trial of each, see your dr or a GI dr for eval. ...Read more