Doctor insights on:
Chemotoxicity: ABRAXANE is an Injectable suspension of paclitaxel , a derivative of Taxol formulated as albumin-bound nanoparticles with a mean particle size of approximately 130 nanometers and sodium acetyltryptophanate . Toxicity of taxol and abraxane are similar and present with numbness, tingling, pain, or weakness in hands or feet; Sudden chest pain or discomfort, wheezing dry cough, Low WBC and fever. ...Read more
Diagnosed with stage 4 pan can. Treated w/Gemcitabine/abraxane combo. Pretreatment ca19-9 was 486. Now ca19-9 is in normal range. What does this mean?
Temporary control: Stage 4 pancreas cancer only be managed with chemo, that is Folfieri (FOLFOX+ Irinotecan). Following this Gemzar (gemcitabine) + Abraxane gives best control as noted by normal Ca19.9 used for monitoring Follow up with serum markers and PET/CAT essential since increase in Ca19.9 suggests need for experimental trial with immunotherapy. ...Read more
Not really: Abraxane is a derivative of Taxol. It is employed after recurrent or metastatic pancreas cancers have failed Gemzar (gemcitabine) adding about 8 wks to the overall survival in these patients. The drug,protein-bound paclitaxel is an injectable formulation of paclitaxel, It has almost the same extent of neuropathy. ...Read more
For chemo treatment, what is the difference between Carboplatin and Abraxane, why are they used at different intervals?
Different origins: Carboplatin is a derivative of the platinum class of drugs including oxaliplatin. Their target is DNA on the surface of the tumor with the purpose of destroying DNA function and is useful in an array of malignancies including breast, ovary, lung. Abraxane is a newer derivative of Taxol and has mostly employed along with or following Gemzar (gemcitabine) in pancreatic Ca. ...Read more
What does it mean the edges are fading on a tumor? 3b nsclc. 26 rounds of rad, 6 chemo. Going to more aggressive abraxane/carboplatin starting 3/3.
Tumor Border notes: First, God bless you and your family for your fight. Keep up your spirits if you can. Tumor border (and size) on CT can help us guess tumor activity but after XRT, fibrosis is hard to separate from viable cells. MRI and esp. PET may be better. These days with "biologic" treatments like Avastin, (bevacizumab) even these modalities may not be prognostic. An HT oncologist may give different insights. ...Read more
Yes it is an option: The standard therapy for ovarian cancer initially is still a taxane (usually Taxol) and Carboplatin. However, Abraxane is an effective taxane down the line for recurrences, and is potentially less toxic. Avastin (bevacizumab) has been combined safely with Abraxane and the two may be helpful for recurrence management. But the question is a bit difficult to answer concretely because circumstances differ. ...Read more
After 39 rounds of radiation, starting full strength Abraxane/Carboplatin on 3/3. What are the side effects and is it effective for 3b nsclc?
Difficult to answer: In a limited space, the common side effects of Abraxane & Carboplatinum include nausea, vomiting, weakness, indigestion, diarrhea, mouth sores, headache, muscle or joint pain, numbness/tingling/burning of the hands/feet, dizziness, infections, anemia, hair loss, low blood counts making you prone to infection, bleeding. In Stage 3B, only about 8% of people survive 5 yrs, WITH radiation then chemo. ...Read more