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Doctor insights on: Abraxane And Avastin

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Can Abraxane and Avastin (bevacizumab) be used for treating ovarian cancer?

Can Abraxane and Avastin (bevacizumab) be used for treating ovarian cancer?

Yes it is an option: The standard therapy for ovarian cancer initially is still a taxane (usually Taxol) and Carboplatin. However, Abraxane is an effective taxane down the line for recurrences, and is potentially less toxic. Avastin (bevacizumab) has been combined safely with Abraxane and the two may be helpful for recurrence management. But the question is a bit difficult to answer concretely because circumstances differ. ...Read more

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Ciii ovarian cancer in 06, 1212, surgery and chemo paxitaxtel/carboplatin. In remission. Recurrence treated with tamoxifen, carboplatin alone, abraxan, then topotacan to no avail. Which chemo next?

Ciii  ovarian cancer in 06, 1212, surgery and chemo paxitaxtel/carboplatin.  In remission. Recurrence treated with tamoxifen, carboplatin alone, abraxan, then topotacan to no avail. Which chemo next?

Many options: Choosing chemo depends on many factors, so only your doctor can decide what might work for you. Drugs you haven't mentioned include altretamine, capecitabine, cytoxan, (cyclophosphamide) vinorelbine, ifosfamide, etoposide, and irinotecan. There are also several hormonal agents. And a clinical trial might be an option. Check out www.Cancer.Gov for more info. And good luck. ...Read more

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How effective is avastin (bevacizumab) as targeted therapy for the metastatic colorectal cancer?

How effective is avastin (bevacizumab) as targeted therapy for the metastatic colorectal cancer?

See below: It is not a curall for colon cancer but is effective therapy to a large extent it depends onthe size and wehre it is. Almost certianly it requires more than this drug to get a cure if acure is possible. ...Read more

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Which is more effective: Avastin (bevacizumab) or Erbitux?

Which is more effective: Avastin (bevacizumab)  or Erbitux?

Identical: Data on Bevacizumab or Erbitux in patients with metastatic colorectal cancer, patients who do not have a KRAS 12/13 gene mutation, have nearly identical survival rates. These identical results were seen after chemotherapy, where survival with chemo alone was about 5 months vs. 7-8 months using either bevacizumab (Avastin) or cetuximab (Erbitux). ...Read more

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Is Abraxane or Taxol (paclitaxel) better for neuropathy?

Is Abraxane or Taxol (paclitaxel) better for neuropathy?

Not really: Abraxane is a derivative of Taxol. It is employed after recurrent or metastatic pancreas cancers have failed Gemzar (gemcitabine) adding about 8 wks to the overall survival in these patients. The drug,protein-bound paclitaxel is an injectable formulation of paclitaxel, It has almost the same extent of neuropathy. ...Read more

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Can gemcitabine be substituted for taxotere (docetaxel)?

Can gemcitabine be substituted for taxotere (docetaxel)?

Gem for taxotere (docetaxel): Short answer is no. It cannot be substituted. Now depending upon the underlying cancer whether lung, breast, pancreatic or any other primary solid tumor, one can use taxol, Abraxane or Navelbine (vinorelbine) (they are taxanes like taxotere). If we want to move to a different agent altogether, then Gemzar or a no of other drugs would be available depending upon what the primary tumor is. ...Read more

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Using avastin (bevacizumab) for macula degeneration treatment?

Using avastin (bevacizumab) for macula degeneration treatment?

Avastin (bevacizumab): Avastin (bevacizumab) is a drug that is commonly used in the treatment of wet macular degeneration and other eye conditions involving leakage of fluid from blood vessels in the retina. ...Read more

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Dr. Craig Lum Dr. Lum
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What can prognosis b like for metastic colon cancer that chemotherapy oxyplatin and raltitrexed ?

Dr. Craig Lum Dr. Lum
1 doctor agreed:
What can prognosis b like for metastic colon cancer that chemotherapy oxyplatin and raltitrexed ?

Colon mets: Not having your chart and you in front of me makes it very hard to give you an accurate idea on prognosis. When chemo is started, that means your CA cells have gone beyond the boundaries which would have made txing it simple. The simpler the tx, the better the prgns. The harder the tx, the worse the prgns. On a positive note, f/u with your docs, stay faithful, and you might get a pleasant surprise ...Read more

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For what cancers does chemotherapy with cytoxan, (cyclophosphamide) 5-fu help?

For what cancers does chemotherapy with cytoxan, (cyclophosphamide) 5-fu help?

Not a standard treat: Cytoxan (cyclophosphamide) and 5-fu jused to be used as first line chemo for breast cancer, but there are much more effacious drugs available now. I would not use these drugs now as first line treatment fofr anything except in special circumstances. ...Read more

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Compare and contrast chemotherapy for aml with chemo for prostate cancer?

Compare and contrast chemotherapy for aml with chemo for prostate cancer?

Different drugs. : Chemotherapy for a hematologic cancer such as AML differs in the drugs & regimens from an epithelial cancer like prostatic carcinoma. AML typically uses Cytarabine and an anthracycline on a specific schedule. In prostate cancer, docetaxel and cabazitaxel are frequently used drugs. Of note, chemotherapy is not as common a treatment for prostate cancer, where hormonal therapy is often used. ...Read more

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What are trastuzumab and herceptin?

What are trastuzumab and herceptin?

Biologic Therapy: Herceptin/trastuzumab is an antibody to a cell surface proteint coded for by the her2neu gene. Its present in some normal cells but in a subset of breast cancers (10-15%) there are multiple copies of the gene producing large amounts of the protein. The herceptin/trastuzumab antibody binds to that protein and reduces that aggressive nature of her2+cancer. It is usually given with chemo. ...Read more

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Why has the drug temozolomide replaced the combination of procarbazine, carmustine and vincristine?

Why has the drug temozolomide replaced the combination of procarbazine, carmustine and vincristine?

Newer treatment: In treatment of Cancer, newer drugs come along and are then compared to the standard(old/conventional treatments). If the new treatment if better(more effective or less toxic) then the new drug takes over and the older drugs put on the back burner. That is what has happened in this instance. This is what has happened in the treatment of brain tumors. ...Read more

Dr. Liawaty Ho Dr. Ho
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49 year old male has stage vi lung adenocarcinoma. No gene mutations receiving chemo and avastin (bevacizumab) received radiation on foot and brain. What prognosis?

49 year old male has stage vi lung adenocarcinoma. No gene mutations receiving chemo and avastin (bevacizumab) received radiation on foot and brain. What prognosis?

It varies according : Patients with stage 4 lung cancer have an average survival of 12 months but there is a wide range from 9 months to 18 months. Some patients can live for 2-5 years but that is rare and only happens if their tumor shows a great response to chemotherapy. ...Read more

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Is avastin (bevacizumab) a good treatment for metastic colon cancer ? Are the side effects harsh ?

GOOD MEDICINE: avastin (bevacizumab) indicated for first line and second line treatment for metastatic colorectal carcinoma in combination with 5-Fluorouracil based chemotherapy side effect is long like weakness,hypertension,vomiting you can google the medicine and you can get the long list follow with your oncologist good luck ...Read more

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Which is the better cytotoxic drug (adriamycin (doxorubicin) or ifosfamide) for synovial sarcoma?

Which is the better cytotoxic drug (adriamycin (doxorubicin) or ifosfamide) for synovial sarcoma?

Chemotherapy for SS: I would potentially seek out an opinion from the mayo clinic oncology department who are not very far north of you. I can help set that up for you. Please contact me at David.stockman@orthopath.com ...Read more

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Adding more chemo dasatinib and carboplatin likely to work?

Adding more chemo dasatinib and carboplatin likely to work?

Restate question: Hi jsalyers9. Can you restate your question with a little more information. What is being treated? What treatments have already occurred? Thanks. ...Read more

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Tx is bi-weekly with fu5 + avastin (bevacizumab). Cea is reliable, tested at start of tx. Cea drops significantly with neulasta/neopogen tx following chemo. Why?

Tx is bi-weekly with fu5 + avastin (bevacizumab). Cea is reliable, tested at start of tx.  Cea drops significantly with neulasta/neopogen tx following chemo.  Why?

Unclear question: Cea dropping is due to chemotherapy. It is a good sign, indicates chemo is working. Neupogen/neulasta are given to increase white cell counts. These are probably unnecessary if you are only taking f-5-fu based chemo. ...Read more

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Is the chemo drug, docetaxel (taxotere) a carboplatin based duplex ?

Is the chemo drug, docetaxel (taxotere) a carboplatin based duplex ?

YES DOUBLET: Taxotere (docetaxel) + carboplatin: is a combination regimen used in certain cancers like lung, ovary and breast (with herceptin). ...Read more