Top
20
Doctor insights on: Abnormal Skin Biopsy Results

Share
Dr. Patrick Sweet III
115 Doctors shared insights

Skin Biopsy (Definition)

A skin biopsy is a way of getting a sample of skin for diagnostic purposes. There are two main ways of doing this. Shave biopsy. A blade is used to cut across the skin. It can leave a scar a bit like a golf divot. Punch biopsy. A device that looks like a little cookie cutter is used to take a cylinder of skin. This goes all the way through the skin and is ...Read more


2

2
Help understand skin biopsy result: "There is a sparse perivascular lymphohistiocytic inflammatory infiltrate. CD117 highlights only a few scattered mast cells. Diagnosis: Mild superficial perivascular infiltrate." Anything of concern here?

Help understand skin biopsy result: "There is a sparse perivascular lymphohistiocytic inflammatory infiltrate. CD117 highlights only a few scattered mast cells. Diagnosis: Mild superficial perivascular infiltrate." Anything of concern here?

See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, the findings listed in the report are non-specific and non-diagnostic. Do you have any symptoms? Why was the biopsy done?

3

3
Recent diagnosis w/autoimmune disease & skin biopsy result: urticaria or mast cell disease. Shouldn't biopsy give more definitive diagnosis?

Recent diagnosis w/autoimmune disease & skin biopsy result: urticaria or mast cell disease. Shouldn't biopsy give more definitive diagnosis?

Hard to tell: Mast cells are the cells that release histamine in the body. This is what happens in urticaria, so one will see mast cells in biopsies of urticarial (hive-like) lesions. Mast cells can also be found in increased numbers in people with mastocytosis. Thus the biopsies may be similar. As stated by my colleague, the clinical history can be key to the diagnosis. Talk with your doc.

See 1 more doctor answer
4

4
Skin biopsy result: superficial to mid dermal perivascular lymphocytic infilitrate with focal basal vacuolar changes. Does thismean allergic vasculitis?

Skin biopsy result: superficial to mid dermal perivascular lymphocytic infilitrate with focal basal vacuolar changes. Does thismean allergic vasculitis?

No: There is no involvement of the blood vessels themselves- thus not vasculitis by definition. This is a very common skin biopsy finding which has no diagnostic meaning other than ruling out a more serious condition.

6

6
Had skin biopsy 2.5 weeks ago ie 12 working days. Results still not in. Terrified this means it will be very bad news. Never taken this long before.

Had skin biopsy 2.5 weeks ago ie 12 working days. Results still not in. Terrified this means it will be very bad news. Never taken this long before.

Delay in report: Does not necessarily mean bad report. Rather than worrying about it, please call your doctor and if s/he has not received the report request that your doctor call the pathologist to whom the biopsy was sent.

7

7
How accurate is a skin biopsy for lupus? Can you have a false/ positive test result?

Lupus biopsy: Biopsy of lupus has a number of features that lead to diagnosis: a thickened basement membrane, vacuolar alteration of basal keratinocytes and superficial and deep inflammatory infiltrate. Lupus has a number of different forms in the skin and there are times when it is not easy to differentiate it from other types of skin inflammation. There are other tests to support diagnosis.

See 1 more doctor answer
8

8
Peripheral neuropathy symptoms for 3 years. Multiple EMG/NCV/Skin biopsy negative. FINALLY repeat skin biopsy WAY below normal. Is this unusual?

Peripheral neuropathy symptoms for 3 years. Multiple EMG/NCV/Skin biopsy negative. FINALLY repeat skin biopsy WAY below normal. Is this unusual?

Well sort of: Like I tell patients all of the time, if you have diabetes or a vitamin deficiency, then pinning down the cause of a neuropathy is easy. Anything else can be quite a challenge and there are literally hundreds of causes for neuropathy otherwise. I'm sure at this point you had a thorough work up, but seeking quaternary care (e.g. Mayo Clinic) is not inappropriate at this point

9

9
We've did a skin biopsy due to a rash. Results were negative for any skin problems. But cortisone shot cleared them up for 3 wks. What would be cause?

We've did a skin biopsy due to a rash. Results were negative for any skin problems. But cortisone shot cleared them up for 3 wks. What would be cause?

Different reasons: Sometimes with the biopsy it is hard to determine the cause of a non specific rash When cortisone works it usually indicates an inflammatory process and the cortisone in some people only lasts a few weeks If it comes back and it is worse then get a second opinion and another biopsy Sometimes if you tell provider the shot worked they will recommend a steroid cream if the biopsy is negative

10

10
How accurate is a skin biopsy?

How accurate is a skin biopsy?

Skin biopsy: This really depends on what is being biopsied. For a "nodule" or "bump, " to rule out cancer, a biopsy is usually likely to give a very accurate diagnosis, although some early forms of cancer can be difficult. Biopsies of "rashes" are more tricky. Sometimes the histology is classical, and a very specific diagnosis can be made. But sometimes the biopsy has a non-specific appearance.

11

11
What is the definition or description of: skin biopsy?

What is the definition or description of: skin biopsy?

Getting a sample: A skin biopsy is a way of getting a sample of skin for diagnostic purposes. There are two main ways of doing this. Shave biopsy. A blade is used to cut across the skin. It can leave a scar a bit like a golf divot. Punch biopsy. A device that looks like a little cookie cutter is used to take a cylinder of skin. This goes all the way through the skin and is often closed with stitches.

12

12
My skin biopsy is infected. What happens?

Topical Antibiotic: Skin biopsies are usually easy to treat because they are superficial and topical antibiotic ointment should be sufficient to make it heal in a few days.

13

13
What does it mean when a skin biopsy itches?

What does it mean when a skin biopsy itches?

Healing: Previous biopsy site itches, most probably because healing. If it is itching for a while show your doctor. Thank for question.

14

14
What is microvascular injury syndrome. Diangosis on skin biopsy?

Descriptive dx...: Many inflammatory skin biopsies are not diagnostic of a particular disease entity. The pathologist can describe the pattern of injury present which usually will help the dermatologist determine what is going on with the clinical history. There is inflammatory damage in your small capillaries-small vessel vasculitis seen in autoimmune diseases often. Direct immuno fluorescence test may also help.

15

15
Is excision skin biopsy is safe after the whole lesion is taken?

Is excision skin biopsy is safe after the whole lesion is taken?

Yes: Likely the initial biopsy showed something worrisome that required your dermatologist to perform an excision to ensure the entire lesion is removed.

16

16
If I took a skin biopsy, would I know whatever is wrong or skin problem I have?

If I took a skin biopsy, would I know whatever is wrong or skin problem I have?

Pathologist: The biopsy should be done by a doctor, from representative lesion, preferable edge of the lesion, a fresh lesion and the specimen should be sent to a pathologist for examination.

17

17
How long will skin hurt at the incision area after a skin biopsy has been done?

How long will skin hurt at the incision area after a skin biopsy has been done?

Less than a day: A clean incision should not hurt for more than a few hours. If the pain persists for more than a day, it would be prudent to contact your doctor.

18

18
Subepithlial stroma is infiltrated with plasma cells. Plasma cells found in skin biopsy? What does it mean? Please explain?

Nothing by itself: This could be any of dozens of skin problems, even a bug bite. You might ask whether the pathologist has any further clues, whether it's worth checking for IgG4-related skin disease, or whether to forget the whole thing.

19

19
Question had skin biopsy do they automatically do a cd3 on every skin biopsy & if cd3 is negative does that r/o lymphoma or do u still have to watch?

Complex question!: Cd3 is on t cells. Your doctor is looking for t cells in your skin biopsy, which can be present for many reasons including allergy. It looks like you have autoimmune disease (positive ANA in the past), so your doctor may be checking to see if your skin lesions are related to that. Based on what you've told me, lymphoma does not come to mind! Ask your doctor what he/she is thinking! Don't worry!

20

20
How long does a skin biopsy appointment usually last? I am nervous about my upcoming biopsy I have scheduled. How long does a procedure like this usually last? .

How long does a skin biopsy appointment usually last? I am nervous about my upcoming biopsy I have scheduled. How long does a procedure like this usually last? .

Depends: The biopsy itself is very quick--can be done in a few minutes. But the appointment can take much longer if you have a lot of questions. Also, if the doctor thinks you have an obvious skin cancer, they may spend more time talking to you about treatment options to get you prepared for the next step.

See 2 more doctor answers
Dr. William Singer
2 Doctors shared insights

Biopsy (Definition)

Biopsy is tissue removed by needle or cutting to remove part of a body part. It is usually a small amount of material that is processed by a pathologist. Most of the time it is stained and looked at through a microscope to arrive at a diagnosis. Special processes are done for some tissues or problems. The purpose is to tell what the problem is (diagnosis). ...Read more