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Doctor insights on: Abnormal Nuclei

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What does it mean to have abnormal lymphocytes with prominent nuclei and clumping on film for a blood test. And enlarged spleen. Possible causes?

What does it mean to have abnormal lymphocytes with prominent nuclei and clumping on film for a blood test. And enlarged spleen. Possible causes?

Many possibilities: Often associated with viral infections such as EBV disease it may also occur with non-infectious inflammatory conditions and with some hematologic malignancies. You do not provide enough info to go further than that, but a good clinical diagnostician should be able to work this out with further testing. Good luck and best wishes. ...Read more

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my BMB report done for thrombocytosis and it stated "Marrow with patchy hypocellularity " also megas with abnormal spidery and/or bizarre nucleus?

 my BMB report done for thrombocytosis and it stated "Marrow with patchy hypocellularity " also megas with abnormal spidery and/or bizarre nucleus?

Means little: Patchy hypocellularity is to be expected at your age; "spidery" nuclei doesn't mean anything in standard pathology, and the "bizarre" nuclei might be better charaterized. Have another pathologist read it out. There are DNA studies to check for essential thrombocythemia which is our major concern now that we ruled out a bunch of bad things which would have shown on marrow. ...Read more

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Why don't platelets have a nucleus?

Why don't platelets have a nucleus?

No need to divide: The nucleus is present in cells that divide or continue to transcribe new genes into RNA and ultimately translate them to protein. Platelets are shed from larger cells called megakaryocytes, and have all the proteins and chemicals they need for their entire life, so no need for a nucleus. ...Read more

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Where does nucleus pulposus develops from?

Where does nucleus pulposus develops from?

Embryology: It originates from a flexible rod-shaped body called the notochord (part of an embryo). The notochord is found ventral to the neural tube. It is found in the center of each disc space and surrounded by the annulus fibrosis. When a disc herniates, the nucleus pulposus escapes from the center of the disc space, navigates through a rent in the surrounding annulus fibrosis, and can push on a nerve. ...Read more

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What is the definition or description of: nucleus pulposus?

What is the definition or description of: nucleus pulposus?

Part of a disc: The intervertbral disc hasteo parts the annulus outside tough ring and the nucleus pulposus the central gelatinous portion the part that squirts past the retaining ring to push on nerveshnp herniated nucleus pulposus disc herniation. ...Read more

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What are the differences between sperm cell nucleus and body cell nucleus?

What are the differences between sperm cell nucleus and body cell nucleus?

Here are some...: Key difference is DNA helices in body is a pair and in germ cell is a half of it, that is, single. Do you have some clinical specific health concern in mind? That should be more interested for most practicing physicians. If you like to explore more on life reality, peruse articles listed in http://www.formefirst.com/onLifeBasics.html. ...Read more

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What happens to the nuclei of the egg and the sperm during fertilizaion?

What happens to the nuclei of the egg and the sperm during fertilizaion?

Here are some...: The answer cannot be described in a 400-letter space. For your search, you may use keywords such "process of fertilization"; here is an example in http://www.wisegeek.com/what-is-the-fertilization-process.htm. ...Read more

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What if fibrodenoma background shows bare bipolar nuclei and stromal fragments ? should it be treated ?

What if fibrodenoma background shows bare bipolar nuclei and stromal fragments ?
should it be treated ?

It's your call: These have to do with the way in which the fine needle aspiration of the fibroadenoma was performed. A little extra physical strength can strip the nuclei and leave bits of stroma. If you don't mind having the lump there, fine. The risk of its turning malignant is very low. If this or any other bump in your breast starts really growing, get seen. http://www.breastpathology.info/fibroadenoma.html ...Read more

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What's herniated nucleus pulposus?

What's herniated nucleus pulposus?

Another name for HNP: Hnp or herniated nucleous pulposus is a portion of the interior of the disc itself known as the nucleus pulposus that ruptures thru the outer pirtion of the disc known as the annulus fibrosis. ...Read more

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What is a herniated nucleus pulposus?

A disc herniation: The nucleus pulposus is the middle soft part of the disc in the spine that normally acts like a cushion. It looks and feels like a thick jelly material. Sometimes, it can leak out if there is a tear in the outside part of the disc (called the annulus fibrosus). When it leaks out, it can pinch a nerve and cause pain that radiates into the extremities. ...Read more

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