Doctor insights on:
Abl T315i Mutation Cell Based
In genetics, a mutation is a change in the nucleotide sequence of the genome of an organism, virus, or extrachromosomal genetic element. Mutations result from unrepaired damage to dna or to RNA genomes (typically caused by radiation or chemical mutagens), from errors in the process of replication, or from the insertion or deletion of segments of dna ...Read more
Can one's DNA change during life? Does that mean that different cells in my body might currently have mutations from one another?
Unregulated growth: The "cell clock" is often referred to as the cell cycle. Think of this as a series of stop and go lights during the lifetime of a cell. Mutations can change a "stop light" to a "green light" resulting in unregulated growth of cells. That unregulated growth can result in the cancer. ...Read more
Is it safe to use kojic acid soap? I've heard that it can cause cell mutation on some mammals. I would plan to use it once a day each night.
Sickle cell anemia: There are many different types of sickle cell anemia. How bad someone's disease is depends on which part of africa their family originally came from and whether the sickle cell gene is combined with any other hemoglobin mutations. For instance, sickle cell + hemoglobin c or sickle cell + thalassemia often gives the patient milder disease than plain sickle cell anemia. ...Read more
It doesn't appear so: I can find no reports of an association between sickle cell anemia and jak2 mutations. Jak2 is a gene involved in promoting growth of red blood cells. The confusion may have arisen from some reports suggesting that stimulators of jak2 might be useful in gene therapy treatments for sickle cell disease. ...Read more
Thyroseq v2 was mutations NOT detected but analysis limited due to low amount of thyroid epithelial cells.So this test was useless?
Totally: B"sd absolutely right - genetic studies should only be done on an appropriate tissue specimen. To my knowlege, specimens are screened for adequacy before such testing. If the biopsy was indicated in the first place then it must be repeated - usually after an appropriate interval to allow the "needled" tissue to heal. ...Read more
Thyroseq neg for mutations But interpret with caution due to marginally low expression of thyroid cell specific markers.Odds higher for benign nodule?
Kras ?Adenocarcinoma? Mutation? New trial drugs with Ins. & Tissue Eval. What is the doctor really saying to 70 year NSCLC pat.9 month ..meets w/new cell grow
Describing the Tumor: So it sounds like the oncologist has really just given you a lot of descriptors to help describe the tumor. The idea is that if we know this information we can select therapies that are more likely to work. For example, whether a patient has a k-ras mutation helps predict whether a tumor may be resistant to a certain drug. ...Read moreSee 3 more doctor answers
Important gene...: Sickle cell anemia is caused by a mutation in the gene that tells your body to make hemoglobin. Hemoglobin allows red blood cells to carry oxygen from your lungs to all parts of your body. In sickle cell anemia, the abnormal hemoglobin causes red blood cells to become rigid, sticky and misshapen. These abnormal red blood cells lead to the various symptoms of the disease. ...Read moreSee 1 more doctor answer
Important gene...: Sickle cell anemia is caused by a mutation in the gene that tells your body to make hemoglobin. Hemoglobin allows red blood cells to carry oxygen from your lungs to all parts of your body. In sickle cell anemia, the abnormal hemoglobin causes red blood cells to become rigid, sticky and misshapen. These abnormal red blood cells lead to the various symptoms of the disease. ...Read more
Sickle: What is the rate of occurrence for the disease sickle cell anemia or disease?" -- the occurrence rate is 25% if both parents are carriers, 50% if one parent has it and another parent is a carrier and 100% if both parents have it. Roughly 1, 000 infants are born, in the U.S., with it each year. ...Read more
Depends on geography: Given the single base change responsible for sickle cell trait in the beta globin gene, the frequency of new mutations is essentially zero. According to the cdc in the usa, 8-10% of african americans have sickle cell trait and 0.2% have sickle cell disease. Conversely, in western africa, the prevalence of sickle cell trait is 30-40%. ...Read more
When chemical (not sure what) induce mutation in spermatogonial stem cell, what's the increase in risk of having de novo genetic defect child?
Be practical: We all carry a few recessive genes that could be a problem.That's why we don't have kids with our sisters. Any chance effect during spermatogenesis is limited by the process of reproduction. It is the healthiest sperm that get to the egg first, so any nasty mutation that would impair the sperm would make it a poor swimmer. Men get this natural pass to some of their exposures not shared by women. ...Read moreSee 1 more doctor answer
I asked about thanataphoric dysplasia & I understand it is a new gene mutation,in which cell? Sperm or ova ? Or permeant change in ovary?
How often do glial cells multiply and divide? Particularly glial cells in the brain stem? What causes cancer to form here? How many mutations?
Can chemical mutagens which enter the testis cause all the spermatogonial stem cells to mutate such that sperm will permanently contain the mutation?
Not likely: It may cause mutations in some or most but unlikely to damage "all" the stem cells. Unless there's a huge dose which would affect other parts of the body as well. As with everything in nature there are outliers that don't get affected or are severely effected by any given event. ...Read more
I have been worrying if the food I eat may cause spermatogonial stem cell to have gene mutation defect, affecting my future sperm even aftermany years?
Hiya, what are the causes of sickle cell anemia? I know it is inherited but i need it explained in a way that can tell me the causes of gene mutation.
Gene mutations: are random. The sickle gene confers some resistance to malaria due to the abnormal configuration of hemoglobin. Sickle trait/sickle cell anemia is most prevalent in populations where malaria is or was endemic. It is likely that the mutation conferred some competitive advantage due to its antimalarial effects and was promulgated through natural selection. ...Read moreSee 1 more doctor answer
With inoperable non-small cell lung cancer, if there's a targetable genetic mutation (EGFR etc) can it be treated at stage 3A? Alongside chemo/radio?
Yes: EGFR mutations (exon 19 or 21) in lung cancer are more common in non-smokers, Asians, and women. Upfront use of an oral tyrosine kinase inhibitor (TKI) results in better progression-free survival than chemotherapy when these mutations are present, although overall survival is not different. Discuss options with your oncologist. ...Read moreSee 1 more doctor answer