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Doctor insights on: Abilify And Cymbalta

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Does cymbalta really increase methadone, and Abilify increases the cymbalta? If so, is it wise to take these meds together?

Does cymbalta really increase methadone, and Abilify increases the cymbalta? If so, is it wise to take  these meds together?

Wow! Discuss w/ Dr!: That's a lot of medications and each one brings increased effects of the others with a particular concern in the combo of Cymbalta and buspirone for serotonin syndrome. Definitely discuss the wisdom w/ your provider but DO NOT stop any of these on your own. Do it under monitoring and consider adding a non-pharma psychotherapy strategy that might help you too. Best ...Read more

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Dr. Vicken Poochikian
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Dr. Alan Ali
280 doctors shared insights

Abilify (Definition)

Abilify (aripiprazole) is an atypical antipsychotic with a unique mechanism of action. As with most atypical agents it is probably prescribed more often for mood disorders than psychotic disorders (like schizophrenia). It's associated with fewer movement side effects (eps) than the typical antipsychotics. It's unique mechanism of action is that it both stimulates ...Read more


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Took Abilify to augment Cymbalta for depression/anxiety. But increased Abilify too fast & got akathisia. On top of akathisia, how badly did I shoot myself in the foot? 1)Just akathisia 2)Nullified augmentation or 3)Worse yet, reduced Cymbalta effect?

Took Abilify to augment Cymbalta for depression/anxiety. But increased Abilify too fast & got akathisia. On top of akathisia, how badly did I shoot myself in the foot? 1)Just akathisia 2)Nullified augmentation or 3)Worse yet, reduced Cymbalta effect?

Skeptical: A healthy dose of questioning is good. The makers of Cymbalta are under fire for deceptive marketing of this medication, though it's definitely helpful for some people and some conditions. Your question poses 3 scenarios associated with Cymbalta Abilify combo. It's likely just akathisia which likely diminishes with reduced dose. The augmentation theory is unsound. Reducing Cymb effect unlikely. ...Read more

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Dr. Vicken Poochikian
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Can both Risperdal low dose 0.25 and Abilify 1mg combined with Cymbalta? ?

Can both Risperdal low dose 0.25 and Abilify 1mg combined with Cymbalta? ?

Yes: You might try all sorts of combinations under the watchful guidance of your psychiatrist. In your case the difficult decisions will have more to do with the Ativan (1 mg twice a day) as you might be experiencing problems with rebound anxiety and precipitation of depression. Don't make any medication changes without consulting with your doctor. ...Read more

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Why Abilify work good with cymbalta and not good with zoloft?

Why Abilify work good with cymbalta and not good with zoloft?

Response varies: Zoloft and Cymbalta work in different ways. This along with individual response may predict my outcomes are different with Abilify in combination with either zoloft or cymbalta. ...Read more

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Dr. Vicken Poochikian
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Abilify is work better with Cymbalta or zoloft?

It doesn't: work specifically better with one vs the other. Adding abilify to antidepressant can help for recalcitrant depression. ...Read more

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A combo of cymbalta & Abilify made my husband have manic episodes. How is stopping Abilify & adding remeron going to calm the manic behavior?

A combo of cymbalta & Abilify made my husband have manic episodes.  How is stopping Abilify & adding remeron going to calm the manic behavior?

Maybe it won't : Manic episodes in the light of antidepressants are either drug induced by the antidepressants themselves or stimulating a bipolar patient into mania - especially when no mood stabilizer on board first - current literature would discourage this practice if the patient is bipolar or at least consider the possibility a mood stabilizer is needed first. (this may help the depression remit alone?). ...Read more

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Any bad interactions adding mobic to cymbalta, abilify, and suboxone? Naproxen isn't helping my golfers elbow.

Any bad interactions adding mobic to cymbalta, abilify, and suboxone?  Naproxen isn't helping my golfers elbow.

No problem: Mobic should be no problem, although it may not be much better than Naproxen and you shouldn't take both the same day. If you were my patient, i could see me suggesting spreading out the suboxone, like a smaller dose more frequently so you are not changing your total daily dose- you're just spreading it out to about every four hours. Please make sure your dr is okay with this first. Good luck. ...Read more

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How safe is it to take cymbalta or abilify?

How safe is it to take cymbalta or abilify?

Safe with monitoring: Both medications are very safe if prescribed by doctors familiar with their use and with appropriate monitoring. The main serious adverse effects have to do with either the fact that the medicines may take a while to have beneficial effects (and during that early period when they have not helped, they can actually make things briefly worse) and preventable long term effects that require monitoring. ...Read more

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Im on Cymbalta 60mg Risperdal 0.25mg can Abilify 1mg add to my medication because Risperdal Abilify both good for me?

Im on Cymbalta 60mg Risperdal 0.25mg can Abilify 1mg add to my medication because Risperdal Abilify both good for me?

That question is: A good one for your doctor. Those types of medication changes are best made in partnership with a physician who knows you, and your medication history, very well. It would be presumptuous of me to give you advice in this context, but your doc will be happy to discuss this with you at your next visit. Best wishes to you! ...Read more

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Cymbalta (Definition)

Cymbalta (duloxetine) is an "antidepressant" medication. However, it is an approved treatment for a variety of indications to include (unipolar) depression, anxiety, and chronic pain (related to diabetic neuropathy, musculoskeletal and/or fibromyalgia). Pharmacologically, it primarily enhances 2 different neurotransmitters (serotonin and norepinephrine). It can cause a ...Read more


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Dr. Vicken Poochikian
Board Certified, Internal Medicine
36 years in practice
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