Doctor insights on:
A False Positive Anti Dsdna
Sle diagnosed based on symptoms & below lab results. Ana 1.48 +ve, anti dsdna 28.5 +ve, ref <20, is there any chance these can be false positive?
At mayo clinic I tested positive for anti dsdna. Latest test says negative (l) dsdna. If positive are you always positive?
Depends on lab: A lot of this depends on what your problems are. Specifically however laboratory studies can sometimes cause conflict. It depends on whether the test was done the correct way, and lab tests can vary even day today. Some labs do a better job than others. This may also depend on the technique of the type of dna test that was done. Your physician can help clarify this. ...Read more
Normal lab test for anti dsdna is < 1:20. Is 1:20 considered negative or positive or borderline? Thank you
Basically negative: With that number it is basically negative, but doctors do not treat numbers we treat patients so that in itself does not rule out lupus. ...Read more
Diagnosed with lupus over 3 years ago based on symptoms & positive anti-dsdna test. Last lab anti-dsdna was neg, will my dr say I don't have lupus?
No: The diagnosis of lupus is based on eleven diagnostic criteria. The dsDNA can sometime become negative if the disease is in remission. A positive test is not needed for the diagnosis of lupus. ...Read more
I tested positive ANA and anti dsdna, later testing neg. I have past diagnosis that may apply to lupus but do not do well articuliatng at dr. Help?
Tests and lupus: The question is why is the doctor running the tests? If your symptoms and physical signs are a strong indication of possible lupus, positive dsdna helps confirm a diagnosis of lupus. If the tests are run for "screening", they are worthless tests. No diagnosis of lupus or connective tissue disease can be made on antibody studies alone. ...Read more
My doctor won't refer me to a rheumatologist, I tested positive for ANA and anti dsdna. He Says I don't need to see one, should I insist to see one?
Possibly: A simple ANA test is positive in 20-30% of healthy people who won't ever develop autoimmune disease. However, a positive anti-dsdna test is much more specific for lupus. It doesn't make the diagnosis, but if you have any concerning symptoms like rash, arthritis, unexplained fevers, chest pain, shortness of breath or other abnormal labs (high ESR, low WBC or platelets, protein in urine), then insist! ...Read more
I've had a positive ANA and anti-dsdna. Plaquenil (hydroxychloroquine) helped but I had mood changes and went off of it and pain is back - what else can I try?
See below: In recent yrs, there have been more choices in meds for ra. Talk to your rheumatologist for your other options, for oral meds, ypu have methotrexate, sulfasalazine, xeljanz. The injectable meds are humira, remicade (infliximab). Don't jusy stop medications without telling your dr. Be well. ...Read more
Negative ANA blood test but positive anti-dsDNA antibodies. Do I have lupus? What causes this? Very symptomatic.
Rheumatologist: This test alone is insufficient to diagnose lupus. It has to be supplemented with appropriate symptoms and physical findings. A rheumatologist is best qualified to evaluate, advise, and treat you, if needed. ...Read more
My left hand and arm have been going numb, with shoulder and neck stiffness in morning. Previously tested positive for Anti dsDNA. Gp thinks nothing?
Need more evaluation:
Numbness may be nerve-related and you may need neurology evaluation. It may be metabolic, like thyroid or sugar. It may be mental, like anxiety disorder.
Positive anti-dsDNA antibody test may indicate an autoimmune disease such as lupus. You need to see a rheumatologist for further testing to confirm this or remove this as a possible cause. ...Read more
I had some reumatology tests, and the anti-dsdna value is 43.2 u/ml. Should I be worried or am suspect of les? Thank you very much
See details: I would recommend you consult with a rheumatologist to determine if these values have any clinical significance. ...Read more
Ana went from 1:80 spck to negative, VHS went from 50 to 10mm in 1week. Negative anti-dsDNA, Antibodies to Ro/SS-A and La/SS-B, RNP and SM. Lupus?
Does it mean I have lupus if my ANA came back at 1:320 when anti-dsdna antibodies and sedimentation are normal?
Ra, hla b27, anti ccp, ana: -ve (cut off rate 1.117, sample rate 0.198), anti-dsdna: -ve (cut off 1.501, sample:0.536). What might be causing my pain?
See details: Pain where? What other issues do you have? Your lab is unremarkable. Without an exam it is impossible to even guess at the cause. There are numerous possibilities. ...Read more
I'm symptomatic, ANA & anti-dsdna neg. W/ a strong family history of sle. Is it worth doing further testing like anti-sm (neg. For infection and iem)?
Negative ANA, negative Anti-DSDNA, negative Sjögren antibodies, normal ESR, normal C-RP, normal CBC. Does this rule out lupus or Sjögren syndrome?
Yes, I would say: Your chance of of having lupus or Sjogren is less than 1 to 2% with those negative serology. But I would say majority (if not all) of rheumatologist would likely advise you to look for other diagnosis unless you have tissue biopsy to suggest otherwise. ...Read more
Crp. 1 mg/l. Ra/anti-dsdna antibs/ana all negative. Why might hematology report indicate "suggested reactive or inflammatory process"? Also noted subset of reactive lymphocytes, occasionally atypical.
See below: Reactive (atypical) lymphocytes are usually due to viral illness or stressor on the body. It could be due to a medicine reaction or autoimmune disorder as well. Your CRP level of 0.1 is very low which is good. And your ra/anti ds dna are negative. So overall they didn't find anything abnormal and they called it possibly due to reactive process. ...Read more
ANA 1:160 homogenous, anti ssDNA 42, normal Rh factor, ESR, anti dsDNA, neg HLA B27. Tests due to severe joint pain- is this indicative of lupus??
Might be.: These labs do not rule lupus out nor do they rule it in. I think your doc should keep looking and monitor your progress over time. Depending upon joints could represent parvovirus although that is just a wild guess. Your clinical picture and progress is most important. ...Read more
Is there any significance to splinter hemorrhages if I have normal results for ANA, anti-dsDNA, anti-Smith, CRP, sed rate? WBC on high end of normal.
May not be: This may be due to trauma. The tests does are not enough as it depends on your evalution by you physician ...Read more
Should I worry about repeat abnormal blood tests if no phys symptoms? Anti-dsdna 24-34, low c3, low platelets 133k. Rheum says not sle & not worry.
Follow up needed!: Good morning, the test results suggests some immune reaction or immune hyperactivity, but not enough to worry about. These may return to normal or get higher in numbers. Follow up by your doctor is suggested. ...Read more
I have had RA, ANA w/reflex, CRP (cardiac), TSH reflex to T4F, sed rate, anti-dsDNA, anti-Smith, all normal. Can I be confident nothing is wrong?
Can anybody?: It seems like you were having an evaluation for arthritis or fatigue (you don't state the symptoms you're concerned about). The studies you got all being normal should be fairly consoling but unfortunately even if we order every imaginable test we can still have one that comes back normal when in fact you have that disease- a false negative. Keep track of your symptoms and get back to your MD ...Read more
I feel like I have the the flu for 3 months, joints, wrist, neck, shoulders. I have a dry mouth and bladder is stressed. Ana1:640 anti-dsdna 1:20. sick?
Can parvovirus b19 cause abnormal blood tests (anti dsdna ~30, low c3, low platelets) for 12 months after virus? Rheum says not sle since no phys symp
Red face, hair loss, wrinkled fingertips. ANA w/reflex: negative. TSH reflex to T4F: 1.660 uIU/mL. Anti-dsDNA: 2. Smith anti: <0.02. What is going on?
Sounds like rheum: I don't understand what you meant by Smith but from what you did state it sounds like you might have a rheumatological condition. See if can find one near you and tell him your history and let him do a thorough exam and laboratory work up. ...Read more
Positive Ana and dsdna. Retest showed neg ana and dsdna, but low c4. What does the low c4 mean? Were first results false positive?
Complex: Sample handling, timing and transport are important, the process is delicate and constitutes multiple steps at different temperatures, and the results are interpreted in context with the clinical picture, just ask your doctor / rheumatologist for interpretation, if just suspicion, observation and follow up are the way to go for many clinicians, wish you wellness ...Read more
Can birth control cause false positive ANA and dsdna using mia testing method? How reliable is this testing method?
Not necessarily: It is pretty unlikely that could be causing those tests to be positive. It does occur on occasion however but I would look for other issues. It could be false-positive. ...Read more
Positive ANA and dsdna of 18 with a normal range of less than 9. Is this a false positive? Only symptoms are joint pain and sun rash.
Lab test results are: Consistent with your symptoms. All lab test results need to be evaluated in the clinical context. Please discuss the issue with your doctor. ...Read more