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Doctor insights on: Transplantation

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Dr. Amy Friedman
1,117 Doctors shared insights

Transplantation (Overview)

Transplantation is the process of transplanting organs from a donor to a recipient and includes surgery and immunosuppressive medical therapy.


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What is a mini-allo transplant?

What is a mini-allo transplant?

Low doses of chemo: Doctors want to capture the anti-tumor effect of the donor's immune cells and they do not need to totally kill all the patient's cancer cells at the time of transplant. These cells will do it over time. Therefore the transplant itself is not as dangerous as a full or standard transplant. However, the serious complications that occur from these same cells causing gvhd are still present. Read more

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Dr. Amy Friedman
1,117 Doctors shared insights

Transplantation (Overview)

Transplantation is the process of transplanting organs from a donor to a recipient and includes surgery and immunosuppressive medical therapy.


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How are organ transplants done?

How are organ transplants done?

See:: Http://www. Webmd. Com/a-to-z-guides/organ-donation-facts

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Why are kidney transplants bad?

Why are kidney transplants bad?

They are not: Much better than indefinite hemo-dialysis or peritoneal dialysis ; far better than dying of uremia (kidney failure). Kidney transplants are associated with complications in many cases, but beefits of kidney transplants far outweigh the risks. Read more

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How can organ transplants work?

Healthy new organ!: When your own organ (s) don't work they fail to perform the key functions that keep you alive. Replacement parts (from another human) are connected to you. Medications are given to prevent your immune system from recognizing that these "new" organs have different DNA than you do, preventing rejection. Technical success + consistent use of medications (every single day!) = success. Read more

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How are kidney transplants done?

How are kidney transplants done?

Kidney transplant: Once the kidney is removed from the donor eithe living or cadaver, the kidney is placed through a lower abdominal incision iusually into the right side of the pelvis and attached the iliac vein and artery and ureter implanted into the bladder. Read more

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How common are kidney transplants?

How common are kidney transplants?

~17, 000 a year in US: In 2013, there were 16, 895 kidney transplants in the U.S. About 11, 000 of them were deceased donor kidney transplants; the rest were living donor transplants. Read more

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What age is too old for transplant?

What age is too old for transplant?

No fixed age: It is hard to fix on a number because there are broad differences between two individuals. It is better to categorize the physiological age rather than the chronological age of a patient. The question to really ask is "does the risk of transplanting a solid organ outweigh the benefit of receiving that organ? " the answer can be subjective and viewed differently among professionals. Read more

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Who should get an islet transplant?

Who should get an islet transplant?

Type 1 diabetics: Islets, the Insulin producin areas of the pancreas, can be transplanted for advanced type 1 diabetes, either in the form of a whole organ, or as islet cell transplants. Most islet cell transplant eventually fail, and, more worrisome, cause antibodies that make subsequent whole organ transplant difficult. The whole organ pancreas transplant is therefore currently the best option. Read more

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Who is eligible for organ transplants?

Depends: Eligibility and allocation varies by organs. For example, kidneys are allocated based on waiting time whereas liver, heart, lungs are allocated based on how sick the patient is. In general, active infections, recent history of cancers, and multi-organ failures might make a patient ineligible. Read more

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Why do some people need kidney transplants?

Why do some people need kidney transplants?

ESKD: Patients who end up with end-stage kidney diseases (ESKD) need kidney transplants. Common causes of ESKD in the U.S. include diabetes mellitus, hypertension, polycystic kidney diseases, glomerulonephritis, and toxins/medications. Read more

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Are animal livers used in human transplants?

Are animal livers used in human transplants?

Not successfully: Animal organs have been used - in experimental circumstances - for a variety of human transplants, without long-term success. Remaining obstacles of rejection are major. When a winning strategy is developed, you will know because we will suddenly be able to address the organ shortage. We can use animal heart valves (usually pig) because they are treated + no longer stimulate an immune response. Read more

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Is there a health requirement for transplant?

Yes: Since all transplants require immmunospression, which can result in a flare up of infection, any current or dormant infection rules out a transplant. Also any cancer can also flare up, so there is a waiting period depending on the type of cancer from a complete cure. Also overall the cardiovascular state of the patient should be enough to tolerate major surgery. Any drug and alcohol abuse is. Read more

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Can you tell me more about organ transplants?

Organ transplants: Its difficult to answer in few sentences.....its a huge field...constantly evolving.....and organ specific....for example solid organ transplant or bone marrow transplants or isolated cell transplants etc.....its very dynamic too. Read more

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What is the success rate of kidney transplants?

Well,: Kidney transplant success rates vary greatly across transplant centers. The average 5 year survival rate is 80-90%, . Read more

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How old is too old to have a kidney transplanted?

How old is too old to have a kidney transplanted?

No precise age: The question is perhaps best answered when the risks of the procedure outweigh the benefits. This occurs at different ages for different patients. It can be a vexing problem if patients are unrealistic about their rehabilitation potential and their goals. It is not common for a kidney transplant to be done over age 75 but a few are done each year, even for healthy octogenarians. Read more

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Could you give me some info on organ transplants?

Broad topic: That's a broad topic. Many organs are transplantable. I refer to you the United Network of Organ Sharing (UNOS) at unos. Org for more information. Read more

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Would like more information on renal transplants?

Would like more information on renal transplants?

Transplant: Kidney transplant is the best option for most patients when their kidney function has progessed to end stage renal disease (less than 15% function). This results in improvement in renal function, BP and clinical status. The big drawback is that you are on life long immunosupression. Read more

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How dangerous is it to have a kidney transplanted?

How dangerous is it to have a kidney transplanted?

Safer than dialysis: Risk assessment is a major part of the txp team's evaluation process. Only pts who are expected to survive at least 3 years should be transplanted, since that is 1 of the key measures used by the gov't to evaluate txp programs. Prolonged dialysis, however, lowers the chance of doing well as pts age + become sicker. If a pt can't walk 1 block (or equivalent activity) pre-txp, survival is unlikely. Read more

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What risks are associated with kidney transplants?

What risks are associated with kidney transplants?

Rejection Infection: After kidney transplantation, the two primary risks are rejection of the organ and infection related to immune suppression medication. There is an ongoing balance between how much your immune system should be suppressed to prevent rejection, but not to allow too many infections to occur. Immune suppression medications can have many side effects such as diabetes, high blood pressure and cholesterol. Read more

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Dr. Julie Abbott
3 Doctors shared insights

Transplant (Definition)

In medicine: a transfer from one body or body part to another of an organ (liver, heart, lung, kidney, pancreas bowel) or tissue (hand, face, hair). The immune system fights foreign invaders (like infections) so it will reject transplants from other people (allotransplants) because they look like infections. So transplants usually require drugs to ...Read more