Doctor insights on:
Paraneoplastic Neurological Syndrome
Removal of primary:
Complete removal of the tumor causing the paraneoplastic syndrome should help. However, the lesions may not be reversible. See this site for more info.
http://www.mayoclinic.org/diseases-conditions/paraneoplastic-syndromes/basics/definition/CON-20028459 ...Read more
Depends on type: There r many paraneoplastic neurologic syndromes, each associated with specific types of cancers. Thus, there's no generic answer to ur question. Paraneoplastic lymphomas, 4 instance, can produce specific antibodies which can b detected by blood tests or lumbar puncture, depending. The best "test"? A thorough history & physical by some1 knowledgeable (oncologist, neurologist) who can guide u more ...Read more
Have had symptoms of paraneoplastic neurological syndrome for 3 years. What tests should I go for?
If this is your own: Self-diagnosis, then the only tests you need at this time is a proper history and evaluation by a competent clinician. That individual will then explain if tests are indicated and what they will be. ...Read more
What is the like hood to have a paraneoplastic neurology syndrome if the paraneoplastic panel (anti body) blood test is negative?
Need more info: It would be worthwhile to discuss this with an oncologist that your family physician can suggest. ...Read more
Well it can. : Paraneoplastic syndromes of the nervous system usually can have varying symptoms of all kinds depending on the body part being injured. One of the things that can be injured is known as Dysautonomia. This means injury to the body functions that are involuntary that includes heart rate. ...Read more
Autonomic neuropathy symptoms for 21 months. Anti hu tested negative. Could this be a paraneoplastic neurological syndrome? Any advice, thankyou.
Symptoms 21 months:
You MUST return to the doctor(s) who have cared for you!
Hope all goes well — please keep me posted. ...Read more
Autonomic neuropathy sympts for 21mths. Anti hu tested neg. Could this be a paraneoplastic neurological syndrome? My GP says don't worry PNS rare. Ideas
Autonomic neuropathy: Occurs in women typically with onset in the 4th or 5th decade. First confirm you have it (see a neurologist and have an EMG-NCS done. If the diagnosis is in question thermal testing and a tilt table test can clarify matters. Read about POTS and its many causes ...Read more
Neurologist or oncologist for paraneoplastic neurological syndrome? Maybe sclc?-smoked 10yr. Now: dysesthesias, fatigue, cold/heat intolerant, no hunger.
See neurologist: Neurologists deal with these things. There are blood tests which can some times help figure these things out. ...Read more
What negative results in paraneoplastic serum panel mean? What the like hood to have the neurology syndrome with negative results?
Based on H&P: A para neoplastic syndrome is based on history and exam. Do not base the absence of a para neoplastic syndrome on a negative serum panel. I rarely get the panel because you treat the person and the disease not the test. Hope this helps. ...Read more
Many: Neurologic paraneoplastic syndromes are caused by an abnormal immune response to the tumor, which makes the body accidentally attack its own nervous tissue. Muscle weakness, stiff limbs, dizziness, coordination problems, vision problems, confusion, difficulty swallowing, memory problems and numbness are some many possible symptoms. ...Read more
Unusual neurological symptoms, Paraneoplastic Panel was done at my request, neuro doesnt suspect it at all based on presentation, waiting for results. How common are FALSE POSITIVE results?
Please repost: Your question is meaningless without a description of your unusual neurological symptoms. The significance of any testing is determined in large part by the pre-test probability of actually having the condition tested for. Furthermore, paraneoplastic syndromes of the nervous system are EXTREMELY rare. I think you can safely find something else to worry about. ...Read more
If PET/CT comes back negative while looking for occult cancer (paraneoplastic neurological sympts) can I relax, symptoms ongoing 2 years. Thanks you.
Is it possible to have paraneoplastic neurological symptoms (not LEMS) from SCLC with no evidence of LC on CT scan 1 year after symptoms started?
What is the best indicator of cancer: "tumor markers" or "paraneoplastic autoantibodies"? I have signs of cancer and neurological autoimmunity.
Neither: There are only a handfuls of very rare circumstances where a "tumor marker" blood test can prove that someone has a cancer. This is because many tumor markers can be elevated by other causes. Paraneoplastic autoantibodies do not diagnose cancer but are called that when a patient with a known cancer has autoantibodies without another known cause. ...Read more
Neurology question concerning an abnormal paraneoplastic panel I was told that my panel had abnormalities in it and that I should have a chest CT scan done and a lambert eaton test and a never conduction study as well. I went to the neurologist because my
Lambert-eaton syndrome is a neuromuscular disorder associated with abnormal antibodies to what are called voltage gated calcium channels. These are channels in the membrane of the nerve part of the nerve-muscle junction. When a signal travels along the nerve to a muscle cell the tip of the nerve makes contact with the muscle cell and forms what is called a neuro-muscular junction. A substance called acetylcholine (a neuro-transmitter) is released into the neuromuscular junction and attaches to receptors on the muscle. The acetylcholine then causes potential changes in the membrane and the muscle cell is activated. The role of the voltage gated channels are to allow for the release of the acetylcholine. If abnormal antibodies are attached to the channels, the acetylcholine can't be released. This results in les. Les is sometimes confused with myasthenia gravis, a condition in which other antibodies are attacking the receptor sites at the nerve muscle junction. Both conditions can cause muscle weakness because both affect the function of the nerve muscle junction. The vgcc (voltage gated calcium channel) antibodies are often seen in people with certain types of lung and thymus tumors sometimes long before the tumor is actually found. A chest ct scan would be done to look for a tumor. An EMG and nerve conduction test would help distinguish between les and mg.
There is an association between autoimmune disorders and les not related to small cell tumors of the lung. There are treatments available. It is good that you don't have ms. Good luck to you. ...Read more
Tumor related: A paraneoplastic syndrome is a condition related to presence of a neoplastic growth but not to the local presence of cancer cells It is mediated by humoral factors expressed by the tumor or from an immune response against the tumor. They most commonly result from the cancers of the lung, breast, ovaries or lymphoma. Symptoms include difficulty in walking, swallowing,and vewrtigo ...Read more
Neurologic and fever: Paraneoplastic syndromes are rare disorders triggered by altered immune system response to a neoplasm. They are defined as clinical syndromes involving nonmetastatic systemic effects. They arise from tumor secretion of hormones, peptides or cytokines arising in tumor and while fever is the most common presentation, several clinical situations observed simulating Cushing and Carcinoid syndrome. ...Read more
Various : Horner syndrome results in a unilateral small pupil, slight drooping of the eyelid, and possible changes in sweating on the same side. It is caused by problems in the sympathetic nerves passing upward in the chest into the neck and toward the base of the brain. Numerous conditions can cause the problem, and this would need extensive testing to find the cause. ...Read more
Cancer related hormo: Cancers like lung cancer can produce chemicals which have hormone like effects on the body. This can cause, for example the calcium level or blood counts to go up. These are called paraneoplastic syndromes, they usually go away once the tumor is removed or controlled with chemotherapy. ...Read more
In what website I can find doctors who diagnose and treat patient with Parneoplastic neurology syndrome?
HealthTap : Which syndrome do you have and how what's this confirmed? (there are about a dozen paraneoplastic syndromes with neurological symptoms. www.healthtap. Com/drericweisman (available at 5 pm today if you want to get started on this) ...Read more
Multiple symptoms: There are several paraneoplastic syndromes. Most are related to the production of excess hormones or tumor necrosis factor or high blood calcium. Neurologic processes can also occur. Your symptoms could be due to a lot of things, but don't sound like a specifric paraneoplastic syndrome to me. ...Read more
Cancer patients: Paraneoplastic syndromes are a heterogeneous group of disorders caused by mechanisms other than metastases, metabolic and nutritional deficits, infections, coagulopathy or side effects of cancer treatment. They may occur before the obvious signs of a malignancy become apparent. ...Read more
Testing: In some patients, paraneoplastic syndromes are clinical findings that accompany existing cancers. These may include changes in the skin, bones, hormone levels, electrolytes, or organ function. Extensive blood testing or scans in a patient with suggestive findings can confirm the diagnosis. ...Read more
Paraneoplastic syndrome is a syndrome (constellation of symptoms of variable types) that occurs in association (para-) with cancer (-neoplastic).
Some specialized testing can detect antibodies involved in paraneoplastic syndrome, but sometimes it is not detectable.
The body parts effected depends on the type of syndrome but may involve the entire body -- eg myasthenia gravis and thymoma. ...Read more
Remote effect.: Paraneoplastic syndrome refers to a remote effect of a malignancy. It is a problem not caused by invasion of a body part by cancer, but instead a dysfunction occuring because of the cancer. Examples in nerve and muscle problems, abnormal blood clotting, and various autoimmune problems. ...Read more