Top
20
Doctor insights on: Neoadjuvant

Share

Neoadjuvant (Overview)

Neoadjuvant therapy is the administration of therapeutic agents before a main treatment. One example is neoadjuvant hormone therapy prior to radical radiotherapy for adenocarcinoma of the prostate. Neoadjuvant therapy aims to reduce the size or extent of the cancer before using radical treatment intervention, thus making procedures easier and more likely to succeed.


1

1
What is adjuvant chemo?

What is adjuvant chemo?

Adjuvant chemo: Adjuvant chemo is chemotherapy that is given after curative surgical resection of a cancer. It is given to reduce risk of recurrence of cancer. ...Read more

Neoadjuvant (Overview)

Neoadjuvant therapy is the administration of therapeutic agents before a main treatment. One example is neoadjuvant hormone therapy prior to radical radiotherapy for adenocarcinoma of the prostate. Neoadjuvant therapy aims to reduce the size or extent of the cancer before using radical treatment intervention, thus making procedures easier and more likely to succeed.


2

2
Estrogen receptor ER positive breast cancer adjuvant Taxol (paclitaxel) benefits?

Estrogen receptor ER positive breast cancer adjuvant Taxol (paclitaxel) benefits?

Get Oncotype: In order to answer this question, more details are needed (size of tumor, lymph node involvement, etc). A test that will help to decide if you need chemotherapy or not is the oncotype dx. I highly recommend you speak with your oncologist and even consider a 2nd opinion. ...Read more

3

3
Colon cancer chemo necessary?

Colon cancer chemo necessary?

Depends on stage: Chemotherapy is never used for stage 1 cancers (early). It is sometimes used in stage 2 cancers (early but more advanced than stage 1). Chemotherapy is definitely beneficial in stage 3 cancers (locally advanced) and in stage 4 cancers (distant spread). ...Read more

See 2 more doctor answers
Dr. Liawaty Ho Dr. Ho
4 doctors agreed:
4

4
Chemotherapy hormone receptor positive node breast cancer?

Dr. Liawaty Ho Dr. Ho
4 doctors agreed:
Chemotherapy hormone receptor positive node breast cancer?

D/W oncologist: Treatment will depend not only the stage but also the biology of the cancer- whether it is estrogen positive, her2neu positive, whether it is lymph node positive or not. Also depends on your preference and overall health condition. Different test like oncotype dx, mammaprint can give you more info-re- recurrence risk of cancer and will be helpful in choosing the right therapy for you.D/w your md. ...Read more

See 2 more doctor answers
5

5
Stage 2B IDC breast cancer, her2+/ER/PR+Neoadjuvant taxol, (paclitaxel)A/C,lumpectomy,rads, lymphovascular invasion. What does this mean for prognosis & follow up?

Stage 2B IDC breast cancer, her2+/ER/PR+Neoadjuvant taxol, (paclitaxel)A/C,lumpectomy,rads, lymphovascular invasion. What does this mean for prognosis & follow up?

Prognosis fair: Stage IIb breast cancer is usually palpable at 2-5 cm. and at time of procedure to remove lesion, sentinel nodes are + suggesting axillary dissection and reason for neoadjuvant therapy. Lymphovascular invasion increases chance for recurrence. With Her2+ Herceptin (trastuzumab) with chemo should be used and PET/CAT needed to assure met foci not missed in distal organs. Carful follow up needed. ...Read more

6

6
Is adjuvant therapy(chemo) effective for non-hodgkin's lymphoma cases?

Is adjuvant therapy(chemo) effective for non-hodgkin's lymphoma cases?

Yes: Chemotherapy is the primary treatment for non hodgkins lymphoma. It's effectiveness depend on several favors like stage, type of lymphoma, and the international prognostic index. ...Read more

See 1 more doctor answer
7

7
What exactly is neoadjuvant chemotherapy?

Chemo before surgery: When chemotherapy is given before surgery it's called neoadjuvant. When chemo or radiation is given in addition to and after surgery it's called adjuvant. It is only describing the order of the treatments. ...Read more

See 1 more doctor answer
8

8
Hepatocellular carcinoma.All spleen and partial liver resection.Later,secondary systemic cancer metastasis.any targeted therapy or immunotherapy?

Hepatocellular carcinoma.All spleen and partial liver resection.Later,secondary systemic cancer metastasis.any targeted therapy or immunotherapy?

Yes, for both: Hepatocellular Carcinoma is commonly treated with Sorafenib which is a type of targeted therapy. This is a good choice of treatment in case you have not yet received this drug. Immunotherapy using PD-1 inhibitors has also shown some modest evidence of benefit although it is not yet FDA approved for this indication. Ask your oncologist to guide your treatment further. ...Read more

9

9
What exactly is adjuvant chemotherapy?

Preventative: Adjuvant therapy, is treatment given following the primary, main or initial treatment. It is usually given after surgery where all detectable disease has been removed, but where there remains a statistical risk of relapse due to occult disease In contrast neoadjuvant therapy, is given before the main treatment to reduce the size of the tumor so as to facilitate more effective surgery. ...Read more

10

10
How effective is avastin (bevacizumab) as targeted therapy for the metastatic colorectal cancer?

How effective is avastin (bevacizumab) as targeted therapy for the metastatic colorectal cancer?

See below: It is not a curall for colon cancer but is effective therapy to a large extent it depends onthe size and wehre it is. Almost certianly it requires more than this drug to get a cure if acure is possible. ...Read more

11

11
Chemotherapy after bladder radical cystectomy needed?

Chemotherapy after bladder radical cystectomy needed?

Perhaps: Chemotherapy following bladder cancer removed by radical cystectomy may be advised depending on the stage of the cancer. A deeply invasive cancer, or a cancer with lymph nodes involved may be treated post-operatively with chemotherapy if chemotherapy was not used preoperatively. ...Read more

12

12
Prognosis stage 3 breast cancer?

Prognosis stage 3 breast cancer?

Curable!: Stage 3 means the tumor is large and/or the cancer has spread to many lymph nodes. It can still be cured with a combination of surgery, chemotherapy and radiation therapy. The risk of cancer returning depends on many factors-- age, # of involved lymph nodes, and whether the cancer has hormone receptors or her2. About 50% of stage 3 breast cancer patients are cured. Have hope! ...Read more

See 1 more doctor answer
13

13
Is stage IV pancreatic cancer terminal?

Is stage IV pancreatic cancer terminal?

Yes?: As a rule, stage 4 cancer of the pancreas is incurable. As to being terminal, it depends on the definition. If you mean it will kill the patient at some point, the vast majority of the times the answer is yes. If you mean it will kill the patient right away, it depends on the situation. Never say never, though, some patients have surprised me in the past. Sorry if it is about you or a loved one. ...Read more

14

14
Colon surgery:tumor size=2cm.Pathologic staging(pt3, n1b, mx).2/17 lymph nodes show metastatic.Margins of resection free of carcinoma.Need chemotherapy?

Colon surgery:tumor size=2cm.Pathologic staging(pt3, n1b, mx).2/17 lymph nodes show metastatic.Margins of resection free of carcinoma.Need chemotherapy?

Yes: Chemotherapy regimens based on the drug Fluorouracil (5-fu) have been part of the treatment for high-risk stage ii or stage iii colon cancer. Many clinical trials have shown that these regimens improve overall survival primarily by reducing the high risk of recurrence within the first two years after surgery. ...Read more

15

15
Pancoast tumor metastisis survival rate?

Pancoast tumor metastisis survival rate?

Pancoast tumor: Occurs at the top of the lung and invades out and up to involve muscles, nerves, and thereby causing pain and horner's syndrome. Metastasis usually means going to another organ. If confined to chest and outward extension (?Metastasis), outlook is more optimistic. If it metastasized to brain, lung, liver or distant bones, the outlook is bleak, seek symptom management, there is no cure. ...Read more

See 1 more doctor answer
16

16
How effective is neoadjuvant therapy for treating colon cancer?

How effective is neoadjuvant therapy for treating colon cancer?

Partially: Chemotherapy in all of its forms is only partially helpful in improving the survival of colon cancer. When there is an effective neoadjuvant response the remaining lesion can be successfully resected. complete surgical extirpation is the needed result. As immunochemo becomes more effective then the combination with surgery will even produce better results. ...Read more

17

17
Which chemo therapy is most effective for KRAS mutant metastic colon cancer ?

Which chemo therapy is most effective for KRAS mutant metastic colon cancer ?

Same drugs as other: Same chemotherapy drugs are used for treating both types of colon cancer. The only difference is lack of benefit from EGFR inhibitors(Cetuximab and Panitumumab). Avastin (bevacizumab) also works in both types. I trust that you know there are 3 chemo drugs that are widely used(5FU or Capecitabine, Irinotecan and Oxaliplatin) ...Read more

18

18
How effective is Xeloda (capecitabine) for metastatic breast cancer?

How effective is  Xeloda (capecitabine) for metastatic breast cancer?

It depends: As the first treatment for metastatic breast cancer, Xeloda (capecitabine) works in 40-60% of people treated. If it is the second, third or later treatment after failure of other agents, the effectiveness is much less. ...Read more

See 1 more doctor answer
19

19
Is metastatic anal cancer terminal?

Is metastatic anal cancer terminal?

Unfortunately: Metastatic disease (also known as stage 4) is usually not curable by todays treatments. Although use of chemotherapy may improve survival and may rarely put someone into a temporary remission the disease usually returns or more often does not go away and eventually progresses and the patient will eventually succumb to it. ...Read more

20

20
Is stage IV metastatic cancer treatable?

Depends: Some cancers are curable with today's chemotherapy even if they have spread extensively. Others (for example, the common lung cancers) may someday be curable when they have reached stage iv, but not today. I've just seen reports of possible cures of stage IV colon and stomach cancers; i'm hopeful. ...Read more