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Doctor insights on: Mastocytosis

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Dr. Brant Ward
44 Doctors shared insights

Mastocytosis (Overview)

Mastocytosis is a condition in which the body produces too many mast cells. These overgrown mast cells can be confined to the skin (cutaneous mastocytosis), or can be located in the bone marrow and throughout the body (systemic mastocytosis). Symptoms of these disorders vary by location and type, but are thought to be caused by the release of chemical mediators like histamine from the mast cells.


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Anyone diagnosed mastocytosis? How?

Anyone diagnosed mastocytosis? How?

Biopsy is best: Cutaneous mastocytosis is confined to the skin and may present with brownish spots that itch or hive when scratched. It can be confirmed by a biopsy of the lesion. Systemic masto involves the bone marrow and presents with whole-body symptoms like flushing or anaphylaxis. High tryptase in the blood can be a clue, but it must be diagnosed by bone marrow biopsy. See a specialist in masto for info. ...Read more

Dr. Brant Ward
44 Doctors shared insights

Mastocytosis (Overview)

Mastocytosis is a condition in which the body produces too many mast cells. These overgrown mast cells can be confined to the skin (cutaneous mastocytosis), or can be located in the bone marrow and throughout the body (systemic mastocytosis). Symptoms of these disorders vary by location and type, but are thought to be caused by the release of chemical mediators like histamine from the mast cells.


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Is 'flushing' symptom heat felt all over the body suddenly? For mastocytosis?

Is 'flushing' symptom heat felt all over the body suddenly? For mastocytosis?

No.: Flushing is the sudden occurrence of redness and heat on the face and upper trunk. When due to mastocytosis it is often accompanied by palpitations, low blood pressure, dizziness, chest pain, explosive diarrhea, nausea, or fatigue. Other things, such as rosacea, medicines, and food additives, can also start a flushing attack. ...Read more

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What are the symptoms of mastocytosis?

What are the symptoms of mastocytosis?

It varies: Mastocytosis in the skin (called urticaria pigmentosa) are reddish-brown "freckles" on the skin that will hive (think of an itchy, red mosquito bite) when scratched or irritated. Mastocytosis throughout the body can present with flushing of the skin, mental "fogginess, " recurrent (often explosive) diarrhea, or even recurrent episodes of anaphylaxis. See a specialist for more information. ...Read more

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What are the signs of mastocytosis or mcas?

Hives, anaphlaxis: Cutaneous mastocytosis typically presents as small brown splotches that turn in hives or welts when irritated, but it can affect the entire skin surface, too. Systemic masto and MCAS typically presents with spontaneous episodes like anaphylaxis--dizziness, fainting, flushing, nausea, diarrhea, and sometimes hives and trouble breathing. See a specialist in masto for more info. ...Read more

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Mastocytosis has specific diagnostic criterion. Does mast cell activation syndrome have specific criterion? If so, what is the criterion?

Mastocytosis has specific diagnostic criterion. Does mast cell activation syndrome have specific criterion? If so, what is the criterion?

Complex: First you must have an elevated baseline tryptase level along with symptoms. Then you will need a bone marrow biopsy to determine what type of mast cell disorders you may have since they all behave the same way. ...Read more

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Anyone know if there is a website with helpful information on mastocytosis?

Anyone know if there is a website with helpful information on mastocytosis?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more

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What would cause severe reactions (fatigue, inflammation)to many foods when you do not have any antibodies against any foods? Mastocytosis? Crohn's?

What would cause severe reactions (fatigue, inflammation)to many foods when you do not have any antibodies against any foods? Mastocytosis? Crohn's?

Celiac disease?: Good morning: many patients mean different scenario when they say reaction. If it is general discomfort it may or may not be due to allergy. For nonspecific symptoms we need to rule out celiac disease. There are different antibodies; ige related to allergy and igg related to inflammation. There are tests to make a diagnosis ordered by a physician. Avoiding gluten may be worth a try. ...Read more

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What does mastocytosis mean?

What does mastocytosis mean?

Too many mast cells: Mastocytosis is an overgrowth of mast cells, immune cells that release histamine and other chemicals upon activation. There are several forms, from small collections of cells in the skin (urticaria pigmentosa) to increased numbers in the bone marrow and throughout the body (systemic mastocytosis). Symptoms vary from hive-like reactions to recurrent anaphylaxis. See a specialist for more details. ...Read more

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How to treat mastocytosis?

How to treat mastocytosis?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more

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Anyone here have treated mastocytosis?

Anyone here have treated mastocytosis?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more

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Anyone know treatment of mastocytosis?

Anyone know treatment of mastocytosis?

Topical steriods: If your mastocytosis is symptomatic, then prescription strength topical steriods are beneficial. ...Read more

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What is a cure for mastocytosis?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more

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Besides a low histamine diet. What is the best way to heal your gut from mastocytosis? Thank you!

Besides a low histamine diet. What is the best way to heal your gut from mastocytosis? Thank you!

Apples: An apple a day - quercetin in apples, stablizes mast cells and prevents degranulation from basophils. They are a natural remedy and should provide minimal side effects. It is also great for people with allergies during allergy season. ...Read more

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What is mastocytosis?

What is mastocytosis?

Too many mast cells: Mastocytosis is an overgrowth of mast cells, immune cells that release histamine and other chemicals upon activation. There are several forms, from small collections of cells in the skin (urticaria pigmentosa) to increased numbers in the bone marrow and throughout the body (systemic mastocytosis). Symptoms vary from hive-like reactions to recurrent anaphylaxis. See a specialist for more details. ...Read more

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Does mastocytosis go away?

Does mastocytosis go away?

Usually: Most cases of cutaneous (just in the skin) mastocytosis start in childhood and will go away as a person gets older. Sometimes the spots may stay but the reactions from them (itching or hives when the spots are irritated) fade over time. Systemic mastocytosis (throughout the body and bone marrow) is much rarer, but usually will not go away. See as specialist in mastocytosis for more information. ...Read more

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Does mastocytosis go away?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more

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How to control mastocytosis?

How to control mastocytosis?

Certain meds: Cutaneous masto can be treated with daily oral antihistamines or cromolyn applied to the skin, but sometimes may not need treatment. Systemic masto is usually treated with antihistamines, plus oral cromolyn for GI symptoms and epipen (epinephrine) for anaphylactic episodes. Aggressive forms may only respond to certain chemotherapy agents. See a specialist in masto for more information. ...Read more

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What does mastocytosis mean?

Too many mast cells: Mastocytosis is an overgrowth of mast cells, immune cells that release histamine and other chemicals upon activation. There are several forms, from small collections of cells in the skin (urticaria pigmentosa) to increased numbers in the bone marrow and throughout the body (systemic mastocytosis). Symptoms vary from hive-like reactions to recurrent anaphylaxis. See a specialist for more details. ...Read more

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What exactly is mastocytosis?

Too many mast cells: Mastocytosis is an overgrowth of mast cells, immune cells that release histamine and other chemicals upon activation. There are several forms, from small collections of cells in the skin (urticaria pigmentosa) to increased numbers in the bone marrow and throughout the body (systemic mastocytosis). Symptoms vary from hive-like reactions to recurrent anaphylaxis. See a specialist for more details. ...Read more

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Anyone diagnosed mastocytosis? How?

Biopsy is best: Cutaneous mastocytosis is confined to the skin and may present with brownish spots that itch or hive when scratched. It can be confirmed by a biopsy of the lesion. Systemic masto involves the bone marrow and presents with whole-body symptoms like flushing or anaphylaxis. High tryptase in the blood can be a clue, but it must be diagnosed by bone marrow biopsy. See a specialist in masto for info. ...Read more