Top
30
Doctor insights on: Mastocytosis

Share
Dr. Brant Ward
44 Doctors shared insights

Mastocytosis (Overview)

Mastocytosis is a condition in which the body produces too many mast cells. These overgrown mast cells can be confined to the skin (cutaneous mastocytosis), or can be located in the bone marrow and throughout the body (systemic mastocytosis). Symptoms of these disorders vary by location and type, but are thought to be caused by the release of chemical mediators like histamine from the mast cells.


1

1
Anyone diagnosed mastocytosis? How?

Anyone diagnosed mastocytosis? How?

Biopsy is best: Cutaneous mastocytosis is confined to the skin and may present with brownish spots that itch or hive when scratched. It can be confirmed by a biopsy of the lesion. Systemic masto involves the bone marrow and presents with whole-body symptoms like flushing or anaphylaxis. High tryptase in the blood can be a clue, but it must be diagnosed by bone marrow biopsy. See a specialist in masto for info. ...Read more

Dr. Brant Ward
44 Doctors shared insights

Mastocytosis (Overview)

Mastocytosis is a condition in which the body produces too many mast cells. These overgrown mast cells can be confined to the skin (cutaneous mastocytosis), or can be located in the bone marrow and throughout the body (systemic mastocytosis). Symptoms of these disorders vary by location and type, but are thought to be caused by the release of chemical mediators like histamine from the mast cells.


2

2
Is 'flushing' symptom heat felt all over the body suddenly? For mastocytosis?

Is 'flushing' symptom heat felt all over the body suddenly? For mastocytosis?

No.: Flushing is the sudden occurrence of redness and heat on the face and upper trunk. When due to mastocytosis it is often accompanied by palpitations, low blood pressure, dizziness, chest pain, explosive diarrhea, nausea, or fatigue. Other things, such as rosacea, medicines, and food additives, can also start a flushing attack. ...Read more

3

3
What are the symptoms of mastocytosis?

What are the symptoms of mastocytosis?

It varies: Mastocytosis in the skin (called urticaria pigmentosa) are reddish-brown "freckles" on the skin that will hive (think of an itchy, red mosquito bite) when scratched or irritated. Mastocytosis throughout the body can present with flushing of the skin, mental "fogginess, " recurrent (often explosive) diarrhea, or even recurrent episodes of anaphylaxis. See a specialist for more information. ...Read more

4

4
What are the signs of mastocytosis or mcas?

Hives, anaphlaxis: Cutaneous mastocytosis typically presents as small brown splotches that turn in hives or welts when irritated, but it can affect the entire skin surface, too. Systemic masto and MCAS typically presents with spontaneous episodes like anaphylaxis--dizziness, fainting, flushing, nausea, diarrhea, and sometimes hives and trouble breathing. See a specialist in masto for more info. ...Read more

5

5
Mastocytosis has specific diagnostic criterion. Does mast cell activation syndrome have specific criterion? If so, what is the criterion?

Mastocytosis has specific diagnostic criterion. Does mast cell activation syndrome have specific criterion? If so, what is the criterion?

Complex: First you must have an elevated baseline tryptase level along with symptoms. Then you will need a bone marrow biopsy to determine what type of mast cell disorders you may have since they all behave the same way. ...Read more

6

6
Anyone know if there is a website with helpful information on mastocytosis?

Anyone know if there is a website with helpful information on mastocytosis?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more

7

7
What would cause severe reactions (fatigue, inflammation)to many foods when you do not have any antibodies against any foods? Mastocytosis? Crohn's?

What would cause severe reactions (fatigue, inflammation)to many foods when you do not have any antibodies against any foods? Mastocytosis? Crohn's?

Celiac disease?: Good morning: many patients mean different scenario when they say reaction. If it is general discomfort it may or may not be due to allergy. For nonspecific symptoms we need to rule out celiac disease. There are different antibodies; ige related to allergy and igg related to inflammation. There are tests to make a diagnosis ordered by a physician. Avoiding gluten may be worth a try. ...Read more

8

8
What does mastocytosis mean?

What does mastocytosis mean?

Too many mast cells: Mastocytosis is an overgrowth of mast cells, immune cells that release histamine and other chemicals upon activation. There are several forms, from small collections of cells in the skin (urticaria pigmentosa) to increased numbers in the bone marrow and throughout the body (systemic mastocytosis). Symptoms vary from hive-like reactions to recurrent anaphylaxis. See a specialist for more details. ...Read more

9

9
How to treat mastocytosis?

How to treat mastocytosis?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more

10

10
Anyone here have treated mastocytosis?

Anyone here have treated mastocytosis?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more

11

11
Anyone know treatment of mastocytosis?

Anyone know treatment of mastocytosis?

Topical steriods: If your mastocytosis is symptomatic, then prescription strength topical steriods are beneficial. ...Read more

12

12
What is a cure for mastocytosis?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more

13

13
Besides a low histamine diet. What is the best way to heal your gut from mastocytosis? Thank you!

Besides a low histamine diet. What is the best way to heal your gut from mastocytosis? Thank you!

Apples: An apple a day - quercetin in apples, stablizes mast cells and prevents degranulation from basophils. They are a natural remedy and should provide minimal side effects. It is also great for people with allergies during allergy season. ...Read more

14

14
What is mastocytosis?

What is mastocytosis?

Too many mast cells: Mastocytosis is an overgrowth of mast cells, immune cells that release histamine and other chemicals upon activation. There are several forms, from small collections of cells in the skin (urticaria pigmentosa) to increased numbers in the bone marrow and throughout the body (systemic mastocytosis). Symptoms vary from hive-like reactions to recurrent anaphylaxis. See a specialist for more details. ...Read more

15

15
Does mastocytosis go away?

Does mastocytosis go away?

Usually: Most cases of cutaneous (just in the skin) mastocytosis start in childhood and will go away as a person gets older. Sometimes the spots may stay but the reactions from them (itching or hives when the spots are irritated) fade over time. Systemic mastocytosis (throughout the body and bone marrow) is much rarer, but usually will not go away. See as specialist in mastocytosis for more information. ...Read more

16

16
Does mastocytosis go away?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more

17

17
How to control mastocytosis?

How to control mastocytosis?

Certain meds: Cutaneous masto can be treated with daily oral antihistamines or cromolyn applied to the skin, but sometimes may not need treatment. Systemic masto is usually treated with antihistamines, plus oral cromolyn for GI symptoms and epipen (epinephrine) for anaphylactic episodes. Aggressive forms may only respond to certain chemotherapy agents. See a specialist in masto for more information. ...Read more

18

18
What does mastocytosis mean?

Too many mast cells: Mastocytosis is an overgrowth of mast cells, immune cells that release histamine and other chemicals upon activation. There are several forms, from small collections of cells in the skin (urticaria pigmentosa) to increased numbers in the bone marrow and throughout the body (systemic mastocytosis). Symptoms vary from hive-like reactions to recurrent anaphylaxis. See a specialist for more details. ...Read more

19

19
What exactly is mastocytosis?

Too many mast cells: Mastocytosis is an overgrowth of mast cells, immune cells that release histamine and other chemicals upon activation. There are several forms, from small collections of cells in the skin (urticaria pigmentosa) to increased numbers in the bone marrow and throughout the body (systemic mastocytosis). Symptoms vary from hive-like reactions to recurrent anaphylaxis. See a specialist for more details. ...Read more

20

20
Anyone diagnosed mastocytosis? How?

Biopsy is best: Cutaneous mastocytosis is confined to the skin and may present with brownish spots that itch or hive when scratched. It can be confirmed by a biopsy of the lesion. Systemic masto involves the bone marrow and presents with whole-body symptoms like flushing or anaphylaxis. High tryptase in the blood can be a clue, but it must be diagnosed by bone marrow biopsy. See a specialist in masto for info. ...Read more

21

21
Anyone have mastocytosis? What is it?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more

22

22
Anyone here have treated mastocytosis?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more

23

23
What are the symptoms of mastocytosis?

It varies: Mastocytosis in the skin (called urticaria pigmentosa) are reddish-brown "freckles" on the skin that will hive (think of an itchy, red mosquito bite) when scratched or irritated. Mastocytosis throughout the body can present with flushing of the skin, mental "fogginess, " recurrent (often explosive) diarrhea, or even recurrent episodes of anaphylaxis. See a specialist for more information. ...Read more

24

24
What is mastocytosis and is it serious?

Mastocytosis: Is an excess number of mast cells. It is usually not an aggressive process. ...Read more

25

25
What can you do to control mastocytosis?

What can you do to control mastocytosis?

Medications can help: Cutaneous (skin-only) mastocytosis can be treated with antihistamines, singulair, (montelukast) and topical cromolyn if the itching, etc., is problematic. The same meds can help systemic mastocytosis, with swallowed cromolyn for GI symptoms. Epinephrine can help resolve anaphylaxis if that occurs. Avoid codeine/opiates and other meds that directly activate mast cells. Talk with a specialist for more info. ...Read more

26

26
How do I find information on mastocytosis?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more

27

27
What is the definition or description of: mastocytosis?

What is the definition or description of: mastocytosis?

Too many mast cells: Mastocytosis is a condition in which the body produces too many mast cells. These overgrown mast cells can be confined to the skin (cutaneous mastocytosis), or can be located in the bone marrow and throughout the body (systemic mastocytosis). Symptoms of these disorders vary by location and type, but are thought to be caused by the release of chemical mediators like histamine from the mast cells. ...Read more

28

28
I have mastocytosis and I want it to go away. What to do?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more

29

29
Anyone out here dealing with mastocytosis and found a cure?

Anyone out here dealing with mastocytosis and found a cure?

See below: Patients with cutaneous and indolent systemic mastocytosis have a favorable prognosis, over 95% of them life expectancy is not reduced. In >50% of the cases of cutaneous mastocytosis in children, there is remission by the time the patient reaches adolescence. In adults it is generally chronic; only in a small proportion of patients with indolent systemic mastocytosis does it tend to regress. ...Read more

30

30
I have mastocytosis and I want it to go away. What can you do?

I have mastocytosis and I want it to go away. What can you do?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more