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Doctor insights on: Macular Degeneration Mutation Analysis

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Is macular degeneration genetic?

Is macular degeneration genetic?

Some: There are a few inherited forms especially those in the young and those associated with drusen deposits that have strong inheritance. Less certain is the inheritance pattern of ordinary, older age macular degeneration - the data is still being worked out. You can help protect your macula with a good diet, avoidance of sunlight and stopping smoking. ...Read more

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Mutation (Definition)

In genetics, a mutation is a change in the nucleotide sequence of the genome of an organism, virus, or extrachromosomal genetic element. Mutations result from unrepaired damage to dna or to RNA genomes (typically caused by radiation or chemical mutagens), from errors in the process of replication, or from the insertion or deletion of segments of dna ...Read more


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What causes juvenile cataracts or macular degeneration?

What causes juvenile cataracts or macular degeneration?

Juvenile cataracts: Congenital cataract: during pregnancy, mom has infection (ie measles/rubella (the most common cause), rubeola, chicken pox, cytomegalovirus, herpes simplex, herpes zoster, poliomyelitis, influenza, Epstein-Barr virus, syphilis, toxoplasmosis. Juvenile: include, prior trauma, infection, inflammation, JRA. Macular degener: gene mutation-> Stargardt's disease, Best disease, and juvenile retinoschisis ...Read more

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Is macular degeneration a genetic problem?

Is macular degeneration a genetic problem?

Maybe: But family history not so critical in this disease- too many genes play a role. ...Read more

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What exactly is macular degeneration?

Two types: This is a failure of the maintainance of the health of vessels supplying the critical, central portion of the retina. In the 'wet' form, the vessels leak and can cause sudden, profound vision loss. The dry form vessels slowly dry up, leading to gradual vision loss. Meds to treat the wet form are available and if successful, convert you to the dry form. Use the areds supplement to slow it down. ...Read more

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Is macular degeneration curabr?

Is macular degeneration curabr?

See Below: Dry (nonexudative) age-related macular degeneration (amd) is treated with areds (age-related eye disase study) vitamins. Wet (exudative) amd is treated with ocular injections (intravitreal avastin, lucentis, (ranibizumab) or eylea). See a retina specialist. There are no cures right now. ...Read more

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How fast does macular degeneration cause vision loss? My doctor would only say it happens slowly, but didn't really define “slow.” is it a couple of years, 10 years, more? I understand each person is different, but what's average? .

How fast does macular degeneration cause vision loss? My doctor would only say it happens slowly, but didn't really define “slow.” is it a couple of years, 10 years, more? I understand each person is different, but what's average?

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Over many years: Macular degeneration is a slowly progressive condition. In the absence of "wei" disease, vision changes start as delayed recovery of vision from bright light, then needing more and moe light to see/read, and eventually progressive decline in visual acuity. For poor vision to develop from the earliest signs is usually decades. At any time, a patient can develop wet disease, needing treatment. ...Read more

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Is macular degeneration the same as retinal degeneration? My eye reports says Bilateral: Defect is consistent with retinal degeneration. I'm 33.

Is macular degeneration the same as retinal degeneration?  My eye reports says Bilateral: Defect is consistent with retinal degeneration.  I'm 33.

Not really: Macular degeneration is a type of retinal degeneration found in the senior population that affects only the center of vision. Many other types of retinal degeneration exist from congenital, to acquired, from hereditary to environmental and from severe to minimal. I would be happy to interpret the report if you send me more details. ...Read more

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How rare is macular degeneration vision impairment?

How rare is macular degeneration vision impairment?

Frequent in elderly: There are a few rare macular degeneration (md) cases in the young but most md is in the elderly. Vision changes can be from minor to severe depending upon the individual. The frequency increases with age up to about 17% affected in those over age 90. If you or a family member/friend has this problem, they should see a retinal specialist for evaluation and possible treatment. ...Read more

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Progressive macular pucker 20/30 vision, distortion & glaucoma. Visual fIeld good,nerve damage 30-45%.Would vitrectomy cause glaucoma to progress?

Progressive macular pucker 20/30 vision, distortion & glaucoma. Visual fIeld good,nerve damage 30-45%.Would vitrectomy cause glaucoma to progress?

Possible: Vitrectomy and glaucoma may have an association. It is suspected that glaucoma occurs more often in patients who have had vitrectomy and subsequent cataract surgery. An ongoing clinical trial is aimed to answer this question with more clarity. PROVE Study. http://www.aaojournal.org/article/S0161-6420(14)00344-3/references AND https://clinicaltrials.gov/ct2/show/NCT01162356 ...Read more

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What is stargardts disease (macular degeneration)?

What is stargardts disease (macular degeneration)?

See below: This genetic disease is sometimes called juvenile macular degeneration. This is no effective treatment for this disease that causes loss of central/reading vision. This disease may likely be treated by gene therapy as only 2 different gene defects are known to cause it. ...Read more

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Is macular degeneration curable?

Is macular degeneration curable?

Unfortunately not.: While there are ways to slow or treat the disease processes in age-related macular degeneration, particularly the wet form, there is presently no cure for the disease. ...Read more

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What causes juvenile cataracts or macular degeneration?

Juvenile cataracts: Congenital cataract: during pregnancy, mom has infection (ie measles/rubella (the most common cause), rubeola, chicken pox, cytomegalovirus, herpes simplex, herpes zoster, poliomyelitis, influenza, Epstein-Barr virus, syphilis, toxoplasmosis. Juvenile: include, prior trauma, infection, inflammation, JRA. Macular degener: gene mutation-> Stargardt's disease, Best disease, and juvenile retinoschisis ...Read more

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I have myopic degeneration. Is that pathological myopia? OD: -15D macular pucker OS: -12D 1mm pigment on retina Both:100% PVD w/floaters gnats flashes

See retina specialit: Do you mean macular degeneration? It appears that you need an eye doctor specialized on the retina and macular. Don't delay another second since your eyesight may depend on it. ...Read more

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Do eye exercises really work? My mother-in-law has macular degeneration. Her doctor told her it's untreatable, so she has turned to the internet and found claims that eye exercises can "improve your vision naturally!" she even made me watch a youtube vid

Do eye exercises really work? My mother-in-law has macular degeneration. Her doctor told her it's untreatable, so she has turned to the internet and found claims that eye exercises can "improve your vision naturally!"  she even made me watch a youtube vid

Nope they don't help: Eye exercise plays no role in the treatment of macular degeneration. Subretinal neovascularization or abnormal growth of vessels is treated with injections of vascular endothelial growth factor inhibitors into the eye. There are a number of investigative drugs for treatment of the dry form of macular degeneration none of which are available for wide release or FDA approved at this time. ...Read more

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Recently diagnosed w/Early stage Fuchs Dystrophy. high densitometry reading & guttate. Past 2yrs glare&hazyvision. Cataracts not the cause. Fuchs?

Recently diagnosed w/Early stage Fuchs Dystrophy. high densitometry reading & guttate. Past 2yrs glare&hazyvision. Cataracts not the cause. Fuchs?

Fuch's dystrophy: Your symptoms of glare &hazy vision is consistent with Fuchs Dystrophy. Also, cataracts can contribute to these symptoms as well. ...Read more

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What causes macular degeneration?

Genetics: The predisposition for macular degeneration is inherited. It is a very complex disease with several, if not many genetic mutations contributing to risk. Additionally, there are other health factors that modulate disease risk. Most importantly nutrition, but also life style (smoking=bad), etc. Rule of thumb: if something is thought to be good for the heart, it probably also reduces amd risk. ...Read more

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What causes Age-Related Macular Degeneration?

Aging: There is still no clear single cause for Age-related Macular Degeneration (AMD). It is a disease of geriatric. The incident is highest among those over 70. Genetic may play a role. Smoking has been shown to increase the risk of progression of the disease. Other conditions have also been cited such as cardiovascular disease. ...Read more

Dr. Richard Scartozzi
578 doctors shared insights

Macular Degeneration (Definition)

A partly genetic disease affecting vision that happens to older people. There are two types: dry or wet, which are ...Read more