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Doctor insights on: Islet/Glutamic/Ia 2/Cpep/Insulin Autoantibodies

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What would cause an intolerance to glutamic acid? Gad autoantibodies? Gad deficiency? Glutamate receptor autoantibodies(anti-nmda, anti-ampa)?

What would cause an intolerance to glutamic acid? Gad autoantibodies?  Gad deficiency?  Glutamate receptor autoantibodies(anti-nmda, anti-ampa)?

None of the above.: Msg - ubiquitous Amino Acid and major excitatory neurotransmitter in brain. Studied extensively. Does not cause allergy or intolerance except at high dose and only then in susceptible persons when given in large doses without food. See fda, j. Nutrition, food chem and toxicology, etc. ...Read more

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Dr. Quang Nguyen
2,780 doctors shared insights

Insulin (Definition)

A hormone produced in the pancreas by the islets of langerhans that regulates the amount of ...Read more


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What would cause an intolerance to glutamic acid? Gad autoantibodies? Gad deficiency? Glutamate receptor autoantibodies(anti-nmda, anti-ampa)?

None of the above.: Msg - ubiquitous Amino Acid and major excitatory neurotransmitter in brain. Studied extensively. Does not cause allergy or intolerance except at high dose and only then in susceptible persons when given in large doses without food. See fda, j. Nutrition, food chem and toxicology, etc. ...Read more

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Can autoantibodies against glutamine synthetase and/or glutamate dehydrogenase cause glutamate metabolism disorders?

Can autoantibodies against glutamine synthetase and/or glutamate dehydrogenase cause glutamate metabolism disorders?

Still searching: Glutamine synthase is part of the glutamine synthetase family. Ammonia incorporation in animals occurs through the actions of glutamate dehydrogenase and glutamine synthase. Glutamate plays the central role in mammalian nitrogen flow, serving as both a nitrogen donor and nitrogen acceptor. I am unble to find references in my search so far as to autoantibodies to these but see comment. ...Read more

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My bl sugar level drops to 50 3 h after eating,normal insulin, c-peptide, liver enzymes' levels,family history of diabetes,is it reactive hypoglycemia?

My bl sugar level drops to 50 3 h after eating,normal insulin, c-peptide, liver enzymes' levels,family history of diabetes,is it reactive hypoglycemia?

Reactive hypoglycemi: yes. It is. Whenever you eat ready sugars or simple sugars( made with table sugar, juices) your body releases lots of insulin . Your sugars get absorbed mostly from stmach and there is still insulin in the blood that continue to lower your sugar.you should avoid ready sugars and take more complex carbs. Along with proteins. You most likely will be developing diabetes in near future. So watch !! ...Read more

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Insulin resistance? fasting insulin 76pmol/l after 75gOral glucose- 1hr-insulin-849pmol/l . 2 hr-864pmol/l glucose fast 5.4mmol/l 1hr10.4 2hr7.5

Insulin resistance? 
fasting insulin 76pmol/l 
after 75gOral glucose- 
1hr-insulin-849pmol/l . 2 hr-864pmol/l

glucose fast 5.4mmol/l
1hr10.4
2hr7.5

Time to get serious: You have normal glucose tolerance. Your fasting and 2 hr glu is not quite at the level of "impaired". Your insulin levels are on the high side, suggesting insulin resistance. Now is the time to start getting your weight under control, proper diet, and physical activity. Talk to your doctor about your particular situation. ...Read more

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What are thyroid peroxidase antibodies?

What are thyroid peroxidase antibodies?

Thyroid antibody: They are made by your own wbcs directed against peroxidase, an enzyme on the thyroid microsome. People with hashimoto's and graves' diseases may have + antibodies to the thyroid peroxidase. ...Read more

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Do elevated gliadin antibodies IgG and IgA mean gluten sensitivity?

Do elevated gliadin antibodies IgG and IgA mean gluten sensitivity?

TTG: I woul recommend having a ttg IgA antibody and possible duodenal bx , in doing so a diagnosis of celiac disease can be made. If if asymptomatic, there may be benefit from a gluten free diet especially if small bowel inflammation noted. ...Read more

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Dr. Alvin Lin Dr. Lin
1 doctor agreed:
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Blood glucose post prandial is 81.00 but serum insulin is2.7?

Dr. Alvin Lin Dr. Lin
1 doctor agreed:
Blood glucose post prandial is 81.00 but serum insulin is2.7?

What's your question: Why was your serum Insulin checked in first place? What's the reference range given for insulin? How did your ordering physician interpret test for you? Why was blood drawn after a meal b/c you need to be fasting in order to calculate your homa-ir? As you can see, too many questions need to be addressed before we even get to your question, whatever it is! ...Read more

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Immunofixation, Serum FAH = Monoclonal IgG kappa immunoglobulin. Beta FAH = 10.5% Abnormal band, immunofixation to follow. I'm IgA deficient too. ??

Immunofixation, Serum FAH = Monoclonal IgG kappa immunoglobulin.   Beta FAH = 10.5% Abnormal band, immunofixation to follow. I'm IgA deficient too. ??

Possibly: If I am understaning this right you have a monoclonal protien band? The most important next steps here would be to identify the band (immunofixation) and then perfrom quantitvaive immunoglobulin levels. IF there is a monoclonal band, you may very well have reciprocal depriciation of alternative immunoglobulins and IgA deficiecny with an IgG monoclonal protein is possible. ...Read more

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Negative result for thyroid peroxidase antibodies tpoab . Necessary to test my thyroglobulin antibodies tgab ?

Negative result for thyroid peroxidase antibodies  tpoab .  Necessary to test my thyroglobulin antibodies  tgab ?

Anti-thyroglobulin: Studies have shown that 99% of patients with hashimoto's thyroiditis have anti-microsomal antibodies, whereas only about 1/3rd had anti-thyroglobulin antibodies. In addition, 10-20% of persons without thyroid problems have anti-throglobulin antibodies (tg-a). These persons are likely at higher risk for future problems and should be watched more closely however, testing for tg-a is not necessary. ...Read more

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Dr. Liawaty Ho Dr. Ho
3 doctors agreed:
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Is the anti-nmda receptor autoantibody considered a paraneoplastic autoantibody?

Dr. Liawaty Ho Dr. Ho
3 doctors agreed:

Anti NMDA ab: It can be found on anti-nmda receptor encephalitis -which can be related to tumor of the ovaries. Anti nmda can be also found on other conditions such as schizophrenia and narcolepsy associated with psychotic features. Please discuss further with your neurologist and your pmd. ...Read more

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My serum test is negative for endomysial antibody iga, ttg tissue transglutasminase iga, gliadin antibody igg. But positive for gliadin antibody iga?

My serum test is negative for endomysial antibody  iga, ttg tissue transglutasminase iga, gliadin antibody igg. But positive for gliadin  antibody iga?

Treat the person: Lab tests mean nothing in isolation, and have many false positives and false negatives. The decision to make a trial of a gluten-free diet will be between you and your gastroenterologist or dermatologist based on the big picture. ...Read more

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Atrial fibrillation, hashimotos, gluten sensitivity and autoantibodies for parietal cells + ATPase and Asialoganglioside autoantibodies. What is prob?

Atrial fibrillation, hashimotos, gluten sensitivity  and autoantibodies for parietal cells + ATPase and Asialoganglioside autoantibodies. What is prob?

A lot: You have at least two autoimmune disorders and potentially a couple more. This points to significant immune dysregulation. If you have joint symptoms also, consider consulting a rheumatologist as well. ...Read more

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Cause of elevations in proinsulin, c-peptides and proinsulin:c-peptide ratio, c reactive protein & ferritin. Normal A1c & glucose. Previously overwei?

Cause of elevations in proinsulin, c-peptides and proinsulin:c-peptide ratio, c reactive protein & ferritin. Normal A1c & glucose.  Previously overwei?

Can't answer: Nobody here can answer without your clinical history, though i wouldn't be surprised if you have hemochromatosis -- truth is, i hope you do, because it's the easiest of all the deadly diseases to manage. It's also worth remembering that serum ferritin is an acute phase reactant and likely to be high during some other illness. You're a person, not a set of labs. Insist on a full explanation. ...Read more

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What would cause an intolerance to glutamic acid? Gad autoantibodies? Gad deficiency? Glutamate receptor autoantibodies(anti-nmda, anti-ampa)?

None of the above.: Msg - ubiquitous Amino Acid and major excitatory neurotransmitter in brain. Studied extensively. Does not cause allergy or intolerance except at high dose and only then in susceptible persons when given in large doses without food. See fda, j. Nutrition, food chem and toxicology, etc. ...Read more

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Can glutamic acid decarboxylase antibody be reduced in the body?

Glutamic acid decarb: Not that I am aware of. There are two forms of this enzyme coincidentally and the antibody is felt to be an autoimmune response to predict Insulin requirement in early type one diabetics. ...Read more