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Hydroxyurea is a cancer agent.
Hydroxyurea is a cancer agent.
HU in sickle cell: Certain patients with sickle cell can be helped by Hydroxyurea (hu). Initially, Hydroxyurea was thought to increase fetal hemoglobin levels (not carrying the sickle cell mutation), but more recently, hu has been shown to decrease high white blood cell counts which can lead to vaso-occlusive crises. Talk with your hematologist to see if hu is right for you. ...Read moreSee 1 more doctor answer
Before 2 yrs old is Hydroxyurea safe for a e beta thallassemia child? She needs transfusion after every 45 days. Pls advice...
Side Effects: There are some serious, but rare, side effects with hydroxyurea, including secondary leukemia, pulmonary fibrosis, pancreatitis, and peripheral neuropathy, or damage to the nerves. Discuss the benefits of decreasing the severity and length of the sickle cell attacks, and the risk of rare side effects as above. ...Read moreSee 1 more doctor answer
Risks vs. Benefits: Hydroxyurea is used to treat sickle cell anemia and some leukemias (blood cancers). As will most medications, there is no official time limit. A medicine that is helpful, is doing a good job, has no equal alternative, and thus is needed, can be used until it is no longer needed. The doctor can explain the risks of "not treating" and of drug side effects, versus the benefits of using hydroxyurea. ...Read moreSee 1 more doctor answer
Depends on situation: What is the reason Hydroxyurea is being given? One use of Hydroxyurea is to treat resistant chronic myelocytic leukemia (cml, a cancer of white blood cells). Cancers increase risk of blood clots (dvt), which can be treated w enoxaparin (clexane) in such a case, both would be given. If in hospital, meds like enoxaparin can be used to prevent dvt. Other scenarios exist in which both could be used. ...Read more
Antimetabolite: Mylocel, or hydroxyurea, is a form of chemotherapy that works to lower blood counts particularly in patients with leukemia such as chronic myelogenous leukemia and myeloproliferative disorders including polycythemia rubra vera and essential thrombocytosis. Short term side effects may include nausea, hair loss, diarrhea, poor appetite, and nail thickening. Long term effects may include infertility. ...Read more
1 month old: Homozygous hemoglobin E disease (genetic; inherited from both parents) gives mild beta thalassemia & anemia & mildly enlarged spleen; probably doesn't need treatment. Hgb E beta thalassemia disease (E from 1 parent, beta thal from the other): severe incurable disease. Hydroxyurea safe in infants. My guess: start early as possible after 1 mo old. Do discuss this with your pediatric hematologist. ...Read more
"Hydroxyurea may affect fertility (ability to have children), whether a man or a woman."Please advice..
It is a chemotherapy drug (a mild one, that doesn't have severe side effects, once it has been checked, worries about it lowering blood counts too much are not much).
It does lower sperm quality and that effect can last after it is stopped.
http://www. Ncbi. Nlm. Nih. Gov/pubmed/17316339 ...Read more