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Doctor insights on: How Does Isosorbide Dinitrate Or Mononitrate Help Prevent Angina Attacks

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How does isosorbide dinitrate or mononitrate help prevent angina attacks?

How does isosorbide dinitrate or mononitrate help prevent angina attacks?

Supply and demand: Angina is caused by heart muscle not getting enough blood to meet its needs, think supply vs demand. By relaxing smooth muscle in the walls of coronary arteries, nitrates increase blood flow. They also dilate the body's veins, so less blood returns to the heart, and the heart walls are less stretched outwards. This reduces tension on the heart wall muscle, and hence demand for oxygen/blood. ...Read more

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Dr. Gutti Rao
1,682 doctors shared insights

Angina (Definition)

Angina is chest pain that is caused by poor blood flow to the heart muscle. Angina is not an actual disease, but rather a symptom of an existing heart problem. Most commonly, this underlying problem is due to an obstruction of the coronary blood vessels that surround the heart. There are different types of angina including stable angina, unstable ...Read more


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How does isosorbide dinitrate and hydralazine work in treating congestive heart failure?

How does isosorbide dinitrate and hydralazine work in treating congestive heart failure?

A-HEFT Trial: A large trial looked at the combination of hydralazien and Isordil (isosorbide dinitrate) with african american patients and showed a benefit of improving heart failure status, on top of standard medical therapy. It is thought to be believed due to lack of Nitric Oxide delivery to endothelium in african americans, that is improved by this therapy. Blood pressure tends to be higher in the first place, which improves. ...Read more

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How does medicinal nitroglycerin for angina affect you?

How does medicinal nitroglycerin for angina affect you?

Dilates vessels: It dilates blood vessels and lowers blood pressure. Burning under the tongue and headache are normal for new users. Esophageal smooth muscle is also affected so relief of pain is not specific for heart disease. Effects occur 2-3 minutes after a sublingual dose and last 20-30 minutes. Gi pain often requires 2 or 3 nitros for full relief. ...Read more

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How effectively does roxonal work for angina pain compared to nitro spray?

How effectively does roxonal work for angina pain compared to nitro spray?

Roxonal: Roxonal is morphine. Morphine in sufficient dose is effective for most pain. We do not blithely prescribe morphine for angina unless all other forms of therapy are exhausted and inadequately effective. Nitro spray works effectively and rapidly for most anginal episodes. We generally use multiple drugs when treating patients with coronary artery disease and when appropriate stents or surgery. ...Read more

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How fast does nitroglycerin act when used to treat a myocardial infarction?

How fast does nitroglycerin act when used to treat a myocardial infarction?

Immediate: Sublingual Nitroglycerin works almost immediately. The effect lasts less than 5 minutes when given under the tongue. ...Read more

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Should i take isosorbide dinitrate or isosorbide mononitrate?

Should i take isosorbide dinitrate or isosorbide mononitrate?

You should take: whichever your health care provider has recommended. Mononitrate has a longer half life and less likely to develop tolerance. Used more commonly in stable angina patients. Ask your health care provider this questions as s/he has your medical history available. ...Read more

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For chest pain/possible coronary artery vasospasms/Prinzmetal angina... How long does it take for Diltiazem to ease the pain?

For chest pain/possible coronary artery vasospasms/Prinzmetal angina... How long does it take for Diltiazem to ease the pain?

Depends: Diltiazem functions to relax the walls of the heart blood vessels. If you take the extended release tablet, it takes about 10 to 14 hours for the drug levels to peak in the blood. Of course, it would take less time for the regular tablets. It is iportnant to take the dose at the same time daily and not miss dose so that the blood levels can get to therapeutic levels and thus control your pain. ...Read more

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Prescribed metoprolol ER (beta blocker)? Only 12.5 mg daily. Is this safe? Can this cause bradycardia or cardiac arrest/heart attack or anything?

Prescribed metoprolol ER (beta blocker)? Only 12.5 mg daily. Is this safe? Can this cause bradycardia or cardiac arrest/heart attack or anything?

Safe: That is a low dose. It can cause a slowing of the heart rate, which can be dramatic and cause symptoms in some individuals. Arrest is rare. You should have your heart rate and ECG checked initially to make sure you are ok on your current dose. ...Read more

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Dr. Alan Ali Dr. Ali
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80 mg propranolol ER vs propranolol. Which is best for long term BP control, anxiaty, and angina.

Dr. Alan Ali Dr. Ali
1 doctor agreed:
80 mg propranolol ER vs propranolol. Which is best for long term BP control, anxiaty, and angina.

Propranolol: Regular release Inderal (propranolol) is mostly potent for anxiety, but i would recommend following through with your cardiologist's recommendation if he/she feels the extended-release works better for your other issues. ...Read more

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What can I do to prevent nightmares from taking lopressor (metoprolol tartrate) beta blocker for my heart?

What can I do to prevent nightmares from taking lopressor (metoprolol tartrate) beta blocker for my heart?

Coping wi/ nightmare: Ask doctor about alternative med. Nightmares arise from meds & other reasons. Develop management skills: learn relaxation, breathing, & visual imagery; practice daily & nightly. This will help heart, bp, mind, general well-being, reduce stress & incidence of nightmares. Use calming skills when nightmares occur & train your brain by rewriting nightmare to outcome you desire. Sweet dreams. ...Read more

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How effective is isosorbide dinitrate for treating coronary artery disease (CAD)?

How effective is isosorbide dinitrate for treating coronary artery disease (CAD)?

Isosorbide dinitrate: Iosorbide dinitrate is beneficial in the treatment & prevention of angina. ...Read more

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Does a daily aspirin work to prevent heart attacks?

Does a daily aspirin work to prevent heart attacks?

Yes: Studies have show that it helps just as does brushing and flossing teeth every night before bed! ...Read more

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How quickly does nitroglycerin act when used to treat a myocardial infarction, i.E. When given in tablet form?

How quickly does nitroglycerin act when used to treat a myocardial infarction, i.E. When given in tablet form?

Almost immediately : Nitroglycerin given under the tongue is very rapidly absorbed into the blood stream. It can begin to work within 30 - 60 seconds to relieve chest pain and increase blood flow to the heart. Taking Nitroglycerin during a suspected heart attack should not delay calling 911 however. ...Read more

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Can beta blockers such as propranolol or toprol (metoprolol) help prevent ventricular fibrillation in susceptible individuals?

Can beta blockers such as propranolol or toprol (metoprolol) help prevent ventricular fibrillation in susceptible individuals?

Beta Blockers: Yes. Beta blockers are antiarrythmic medications as well as an anti-hypertensive medication. It counteracts the effects of catacholamines like Epinephrine which can cause tachycardia, hypertension and in susceptible individuals ventricular fibrillation. ...Read more

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How does coreg (carvedilol) compare to other bb's with regard to angina relief?

How does coreg (carvedilol) compare to other bb's with regard to angina relief?

Coreg (carvedilol): Coreg (carvedilol) is also effective for angina. The dose titration for angina needs to achieve rate control which is a bit different from the CHF dosing. ...Read more

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How does isosorbide dinitrate or mononitrate help prevent angina attacks?

Supply and demand: Angina is caused by heart muscle not getting enough blood to meet its needs, think supply vs demand. By relaxing smooth muscle in the walls of coronary arteries, nitrates increase blood flow. They also dilate the body's veins, so less blood returns to the heart, and the heart walls are less stretched outwards. This reduces tension on the heart wall muscle, and hence demand for oxygen/blood. ...Read more

See 1 more doctor answer
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Whats the difference between isosorbide mononitrate vs isosorbide dinitrate?

Whats the difference between isosorbide mononitrate vs isosorbide dinitrate?

How long they last: The main difference is how long they last. Most dinitrate products are designed to be taken at least 2 x a day where as most of the mononitrate products once a day. They both are quite effective at controlling angina when appropriately prescribed. Some side effects thought a bit less with mono v. Di, but that varies a lot from person to person. ...Read more

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Should i take isosorbide dinitrate or isosorbide mononitrate?

You should take: whichever your health care provider has recommended. Mononitrate has a longer half life and less likely to develop tolerance. Used more commonly in stable angina patients. Ask your health care provider this questions as s/he has your medical history available. ...Read more

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Could you explain what is isosorbide dinitrate (isoket spray) ?

RU in the UK?: Isoket spray is not available in the usa . It's a form of Nitroglycerin and it's used under the tongue for rapid relief of angina spells. In the usa, we use Nitroglycerin as a tablet or a spray and we use Isosorbide Dinitrate tablets for longer lasting relief/prophylaxis of angina. ...Read more

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In a patient with migraines, will their frequency increase if the patient takes isordil (isosorbide dinitrate)?

In a patient with migraines, will their frequency increase if the patient takes isordil (isosorbide dinitrate)?

Isordil (isosorbide dinitrate) & Headaches: Isordil is nitroglycerine, a vasodilator for the heart( seldom other) which can cause headaches. It is dose dependent, the higher the most likely headache. You may take tylenol (acetaminophen) for it. If your migraines get worst talk to the cardiologist about it. ...Read more

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How effective is isosorbide dinitrate for treating coronary artery disease (CAD)?

Isosorbide dinitrate: Iosorbide dinitrate is beneficial in the treatment & prevention of angina. ...Read more

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What is isosorbide dinitrate?

Isosorbide dinitrate: Iosorbide dinitrate is a medication used to treat/ prevent angina. ...Read more

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Who should not use isosorbide dinitrate?

Isosorbide dinitrate: "Allergic reactions to organic nitrates are extremely rare, but they do occur. The isosorbide dinitrate tablet is contraindicated in patients who are allergic to ISDN or any of its other ingredients." See: http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8bb91825-b63e-44aa-8edd-4326823f3009 ...Read more

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What are some of the disadvantages by using isosorbide dinitrate?

Minor: Some people have issues with headaches or low blood pressure. Both of these resolve if the medication is stopped. ...Read more

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How does isosorbide dinitrate and hydralazine work in treating congestive heart failure?

A-HEFT Trial: A large trial looked at the combination of hydralazien and Isordil (isosorbide dinitrate) with african american patients and showed a benefit of improving heart failure status, on top of standard medical therapy. It is thought to be believed due to lack of Nitric Oxide delivery to endothelium in african americans, that is improved by this therapy. Blood pressure tends to be higher in the first place, which improves. ...Read more

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To control CHF is it normal to prescribe hydralazine alone or with isosorbide dinitrate? she has no hypertension, but AF. headache+AF worsens wt these

To control CHF is it normal to prescribe hydralazine alone or with isosorbide dinitrate? she has no hypertension, but AF. headache+AF worsens wt these

Yes: The combination of hydralazine and isosorbide reduce filling pressures in the heart, reduce the amt of work the heart must do, & reduce the changes in structure to the heart that heart failure brings. This is for heart failure where the ejection fraction is less than 40%. ...Read more

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If you are feeling these side affect numbness tingling of hands legs and feet from taken carvedilol isosorbide dinitrate and hydralazine?

If you are feeling these side affect numbness tingling of hands legs and feet from taken carvedilol isosorbide dinitrate and hydralazine?

Antihypertensives: The medications above are used to treat high blood pressure. They are usually tolerated well but uncommonly do have side effects. New onset numbness and tingling has many causes and isn't necessarily related to your medications. ...Read more

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Need to take 30 mg ER imdur for angina. Would it cause low blood pressure.How effictive it is vs regular isosorbide regular release on blood pressure?

Need to take 30 mg ER imdur  for angina. Would it cause low blood pressure.How effictive it is vs regular isosorbide regular release on blood pressure?

Nitrates: Both may cause some drop in blood pressure but usually not very much. Nitrates are not typically used for treatment of hypertension. The effects of the short and long acting isosorbide mono nitrate are similar; the difference is how often it has to be taken, i.e. Once vs. Twice a day. ...Read more

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Can pregnant women take isosorbide dinitrate?

Isosorbide dinitrate: Isosorbide dinitrate is FDA Pregnancy Category C (Risk cannot be ruled out.) ...Read more

Dr. David Earle
20 doctors shared insights

Isosorbide Dinitrate (Definition)

Isosorbide dinitrate is a nitrate based agent which is a kind of chest ...Read more


Dr. Michael Gabor
13 doctors shared insights

Dilatrate Sr (Definition)

Dilatrate SR is a nitrate based agent which is a kind of chest ...Read more