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Doctor insights on: High Islet Cell Antibody

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I have heriditary pancreatitis. Had islet cell done. 2 year out. My lym are high 5.26 WBC 12.7. Is this still within a ok range. I worry about cancer.

I have heriditary pancreatitis. Had islet cell done. 2 year out. My lym are high 5.26 WBC 12.7. Is this still within a ok range. I worry about cancer.

A rare inherited: Condition characterized recurrent episodes of acute pancreatitis. It can progress to chronic pancreatitis. Yes, there is a link to an increased lifetime risk of pancreatic cancer. Are you having any symptoms now? Any screening for cancer done? Like mri, ct scan, ercp, ultrasuound, ca-19-9 level. You should have a primary care physician following you and also a gastroenterologist that know you. ...Read more

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


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Dialysis patient. 1 transfusion. My antibody count was to high to be admitted to a study on stem cells. Living donor. Anyway to lower antibodies count?

Dialysis patient. 1 transfusion. My antibody count was to high to be admitted to a study on stem cells. Living donor. Anyway to lower antibodies count?

Not really: Antibody titers increase as a reaction to the antigen. Antigens are molecules (structures) on cells that give them a unique identity -- and so give you a reference to "self" or "not-self." in this case, you are making antibodies to something that cross reacts with the stem cell study (or equivalent). You can try to calm the immune system down (this is what medications do), but it is iffy. ...Read more

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What might cause hyperthyroid, high anti-centromere b antibodies, enlarged red blood cells and high iron saturation, normal serum iron, low TIBC/UIBC?

What might cause hyperthyroid, high anti-centromere b antibodies, enlarged red blood cells and high iron saturation, normal serum iron, low TIBC/UIBC?

THIS IS A "LONGSHOT": But this set of symptoms (SYNDROME) sound like HASHIMOTO's THYROIDITIS and PERNICIOUS Macrocytic anemia also may be AUTO-IMMUNE!!!
in nature ie: the body falsely detects NORMAL TISSUE as being "FOREIGN" and develops auto-antibodies against (in this case) your thyroid gland and your bone marrow)
This is a guess....just a "thought". hope it helps!
Dr Z ...Read more

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My blood test showed an elevated level of tg antibodies. Does that mean I have cancerous cells running around? Had papillary thyroid cancer a year ago

My blood test showed an elevated level of tg antibodies. Does that mean I have cancerous cells running around? Had papillary thyroid cancer a year ago

Not necessarily.: Having elevated tg antibodies primarily means that the more important tg test itself will be falsely lower than its true value. (no conversion formula exists.)

if your tg antibodies are only 20 or so, with an undetectable tg level, it is hard to know what that means. If your tg antibodies are much higher, then concern for the presence of thyroid cancer would increase. ...Read more

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I've been diagnosed with cmml. What is the treatment, prognosis (how long does one have to live with this. Is it painful became ill and white cell count was 89000, got under control with antibiotics. Monocytes have been high for at least 6 six years.

I've been diagnosed with cmml. What is the treatment, prognosis (how long does one have to live with this. Is it painful became ill and white cell count was 89000, got under control with antibiotics. Monocytes have been high for at least 6 six years.

It: It is good that you are trying to read and find out more about your condition. Chronic myelomonocytic leukemia is a serious diagnosis, but there are many new aggressive treatments for your condition. This is a website from american cancer society that I find very helpful:

http://www. Cancer. Org/cancer/leukemia-chronicmyelomonocyticcmml/index

be sure that you feel completely comfortable with your hematologist and that you get aggressive treatment, as there are many treatments available.

Be careful when reading literature, because we all worry about the worst situations, which literature mainly addresses. Be sure to talk to other patients who have had this and you will hear more positive stories of success also. ...Read more

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Blood in urin on antibiotics and not clearing up test said white blood cell count high what does that mean?

Blood in urin on antibiotics and not clearing up test said white blood cell count high what does that mean?

Sign of infection: An elevated white blood cell (WBC) usually indicates an infection. That it is not clearing up may indicate a different antibiotic is needed. Check with your physician. ...Read more

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Just been diagnosed with chronic myelomonocytic leukemia. What is the treatment. Is this painful and is the treatment painful. Became ill and white cell count went very high but got under control with antibiotics, monocytes have been high for at least 6 ye

Just been diagnosed with chronic myelomonocytic leukemia. What is the treatment. Is this painful and is the treatment painful. Became ill and white cell count went very high but got under control with antibiotics, monocytes have been high for at least 6 ye

Chemotherapy: In most cases, like any other leukemia, the treatment consists of combination chemotherapy and the options are best discussed with your oncologist. Chemotherapy does have various side effects and those should also be discussed with your oncologist before starting treatment. ...Read more

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High white blood cell count, bad headaches for weeks (antibiotics won't work), and lump behind ear (hard & tender, but moves slightly) is it lymphoma?

High white blood cell count, bad headaches for weeks (antibiotics won't work), and lump behind ear (hard & tender, but moves slightly) is it lymphoma?

Yes, but...: I didn't know about your high white count when I answered before. An infection or inflammatory problem is still most likely. See a healthcare provider again. The lump behind your ear being tender argues against lymphoma. Most lymphomas cause large, rubbery lymph nodes that aren't tender. You could have a bad sinus infection. Try not to let fear keep you from getting the health care you need! ...Read more

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High fever sore throat, skin sores, painless after fever broke, white blood cells fighting virus?, then died, harmless? Treatment? Antibiotics ness.?

High fever sore throat, skin sores, painless after fever broke, white blood cells fighting virus?, then died, harmless? Treatment? Antibiotics ness.?

See your physician: Skin rash with fever can be due to numerous potential viral or bacterial infections. See your primary care physician or a dermatologist for a work up including further lab work, cultures, and possible skin biopsy. This will hopefully guide treatment. ...Read more

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What disease dose this lead too?! Elevated white blood cells count Elevated serum lactate Blood couture positive No antibiotics present in system

What disease dose this lead too?! Elevated white blood cells count Elevated serum lactate Blood couture positive No antibiotics present in system

+ blood culture: If you have positive blood cultures you most likely need to be treated with intravenous antibiotics, otherwise you can develop serious and life-threatening complications like an infection/abscess in the heart valves or a stroke. Make sure you get the proper medical treatment! ...Read more

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I had a common cold but all types of my white blood cells are elevated? Had antibiotic the day after I had a CBC test?

I had a common cold but all types of my white blood cells are elevated? Had antibiotic the day after I had a CBC test?

Hmm: Unfortunately viruses can cause elevated white blood cells. I would speak to the doctor who prescribed the antibiotics and follow up with them. Good luck. ...Read more

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When patient has autoimmune flares that cause weeks of glucose intolerance and diabetes-type symptoms that resolve, would it be useful to test for antibodies to gad, insulin or islet cells?

When patient has autoimmune flares that cause weeks of glucose intolerance and diabetes-type symptoms that resolve, would it be useful to test for antibodies to gad, insulin or islet cells?

Possibly: Autoimmune diseases tend to occur together, so checking for antibodies for type 1 dm can be helpful to assess for that diagnosis. Glucose tolerance should not fluctuate with a flare in gad/insulin/islet abs. It it more likely to be from treatment of the autoimmune flare (steroids) or stress from the flare. ...Read more

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What is an islet cell cancer?

What is an islet cell cancer?

Tumor of pancrease (pancrelipase): Islet cells are the cells located in the pancrease (pancrelipase) that make insulin. A tumor can form there from a degrading of the islet cell into an abnormal form and then cancerous. Hope this helps. ...Read more

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What about neuroendocrine (islet cell tumors)?

What about neuroendocrine (islet cell tumors)?

Interesting tumor: Overally, neuroendocrine tumors are often capable of over-producing hormones that your body naturally makes. Islet cells are cells that are naturally present in the pancreas and produce a number of hormones, most notably insulin. Insulin helps you break down and digest sugars. Patients with an islet cell tumor can produce too much Insulin resulting in weight & gain and low blood sugars. ...Read more

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Should I be concerned if my wife wants an islet cell transplant. What do you think?

Should I be concerned if my wife wants an islet cell transplant. What do you think?

Weigh the options: Islet cell transplants are performed, and many patients have been helped by them. In particular, to treat the terrible symptom of hypoglycemic unawareness. Like any surgical procedure there are risks and benefits that should be carefully discussed and understood before you go forward with the procedure. ...Read more

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Can you tell me how to find out if the islet cell transplant is for me, or if im eligable for it?

Evaluate carefully: You need to have a careful discussion of your degree of diabetes, and the risks and benefits of the procedure. Find a local transplant center that does the proceed and go over these issues point by point. Procedure itself, results short and long term, medications needed, their side effects, etc. Contact the american society of transplant surgeons for centers in your region. ...Read more

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What is the definition or description of: Islet cell carcinoma?

What is the definition or description of: Islet cell carcinoma?

Pancreatic islets: Islet cell tumors of the pancreas represent the second form of lesion, the first representing lesions of ductal origin that lead to the classic pancreatic carcinoma, most frequently arising in the head.
The second group of tumors, those of neuroendocrine origin arise in clustered cells known as islets and which are mainly benign When malignant they spread with a survival of about 5% ...Read more

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I've developed islet cell carcinoma. What should I be watching out for in the future?

I've developed islet cell carcinoma. What should I be watching out for in the future?

Difficult to say: Islet cell tumors are rare forms of cancer that arise in the endocrine tissues of the pancreas. They can secrete a variety of hormones, including insulin, glucagon, gastrin, and vasoactive intestinal peptide, resulting in a myriad of clinical syndromes. However, the majority are not associated with a hormonal syndrome, and therefore, yours may have been detected incidentally. I need more info. ...Read more

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Can you tell me how are b-cells and antibodies presented with antigen?

Form hybridoma: When an antigen is given to an animal, B cells in serum produce a polyvalent antibody prep. When antigen is given to an animal and spleen cells (B) are fused with malignant B cells, a hybrid clone is formed producing monoclonal antibodies to the specific protein antigen. ...Read more

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Do beta cells grow back if you can block the diabetes antibodies against them?

Do beta cells grow back if you can block the diabetes antibodies against them?

No (not yet): So far, trials of powerful immune-suppression drugs have not been able to prevent type 1 diabetes in kids who have antibodies or other predisposition. This research is ongoing, however. Check out trialnet for more information. ...Read more

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Is the islet cell transplant a solution for those with chronic pancreatitis?

Is the islet cell transplant a solution for those with chronic pancreatitis?

Not at this time: Rx is to treat the diabetes (can be difficult), pain relief, supplemental enzymes, avoiding alcohol, sometimes surgery. ...Read more

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Rehsus blood red cell antibodies, what are these?

Useful in pregnancy: Rhesus (Rh) factor is an inherited protein found on the red blood cells. If your blood has it, you're Rh positive. If your blood lacks it, you're Rh negative. Rh positive is the most common blood type. Having an Rh negative blood type is not a problem but It becomes important if the mother who is Rh negative develop Rh antibodies, from an Rh+ fetus; as these can cross placenta and cause problems. ...Read more

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How can HIV stimulate b cells to produce antibodies?

How can HIV stimulate b cells to produce antibodies?

Infection: Like any infection by a foreign "invader", HIV induces an antibody in an effort to fight back. The issue is that HIV kills T cells, a different type of immune cell. B cells are activated to make the antibody but the antibodies are not strong enough to stop HIV from infecting, replicating inside of and then killing T cells. ...Read more

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Can you tell me how HIV stimulate b cells to produce antibodies?

Homework: Physicians do not do their patients homework for them. Plagiarism is frowned upon in education. Your question would take up an entire chapter in a textbook. Go read the chapter and answer your assignment in your own words. ...Read more

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What's the difference on Antibodies/Antigens on the exterior of the cell vs the interior while testing and worried about the sensitivity/accuracy?

Please Clarify: Your question is very vague. There are thousands of Antibodies and millions of Antigens. If not more. Which in specfic are you interested to find out about. Please think it through what exactly do you want to know? ...Read more

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What's the latest on "islet cell transplantation" for type 1 diabetics?

What's the latest on "islet cell transplantation" for type 1 diabetics?

Not so good: We have a long way to go. The edmunton protocol, the latest attempt at transplanting islet cells is not working out as well as we would like for patients with type 1 diabetes.
There are other attempts on the horizon - stay tuned. ...Read more

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Pancreatectomy with autologous islet cell transplantation: what does this mean?

Saving insulin: When an islet cell transplant has to be performed it means that the pancreatectomy was total. The pancreas is an exocrine (digestive juice) and endocrine gland from the Islets of Langerhans. When all are removed, islet transplant helps retain endocrine activity including insulin production. ...Read more