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Doctor insights on: Graft Versus Host Disease

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What are the symptoms of graft-versus-host disease?

What are the symptoms of graft-versus-host disease?

There can be many...: Acute GVHD presents as a skin rash, gut symptoms (nausea or diarrhea) or jaundice. Chronic GVHD commonly causes dry eyes and dry mouth but they can also get quite sore. More serious symptoms of chronic GVHD include sclerosis (scarring or thickening) of the skin, or reduced flexibility due to connective tissue inflammation (fascitis). Pulmonary airflow obstruction may cause shortness of breath. ...Read more

Dr. Richard Roberts
231 doctors shared insights

Genetic Disease (Definition)

A genetic disease is a disease that is caused by a defect in the genetic (dna) material in a gene(s). It can be inherited and mosy pose a risk to other family members and/or to future children. For many genetic diseases there are molecular tests that allow detection of a change(s) called mutations, we can also detect deltions or other changes to the gene's dna that can also result ...Read more


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Can radiology be used to diagnose graft-versus-host disease?

Physical examination: ...and biopsies are the mainstay of diagnosis of graft vs. host disease. Radiology is used mostly to exclude other causes of symptoms, such as an ultrasound of the liver to exclude biliary obstruction, or CT of the chest to exclude infection. ...Read more

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What is the difference between graft-versus-host disease and rejection?

GVHD is a reaction..: of engrafted immune cells against the patients healthy tissues. It leads to inflammation and side effects in a variety of tissues. Rejection is the opposite. It is a reaction of the patients immune system against the engrafted cells. In the case of a bone marrow transplant, rejection would cause disappearance of the cells in the marrow and a drop in blood cell production. ...Read more

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Hodgkins lymphoma graft-versus-host disease, what is this?

Cellular immunity: Graft vs. host disease (GVHD) occurs when T lymphocytes from a donor cause inflammation in the normal tissues of a patient. This is a common side effect of allogeneic bone marrow transplants because billions of T cells are infused along with the bone marrow stem cells. It can also occur as a rare, unintended consequence of blood transfusion in Hodgkins patients. ...Read more

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Treating Pelvic Inflammatory Disease (Checklist)

Ask your doctor for further STD testing
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Ask your partner to get tested for STDs
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Take all of your medication exactly as prescribed
Once
Use condoms when having intercourse to prevent STD transmission
Once
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What is the medical definition of graft-versus-host disease?

GVHD: occurs when bone marrow stem cells and/or immune cells have been engrafted from one individual into another. Except in identical twins, differences in cellular antigens cause engrafted cells to react against the host tissues and cause an inflammatory injury. Acutely, symptoms may affect the skin, liver, or gut; whereas chronic GVHD may affect the eyes, mouth, fascia, and lungs. ...Read more

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What is an appropriate diet for someone with graft-versus-host disease?

What is an appropriate diet for someone with graft-versus-host disease?

A healthy diet: is important for GVHD patients, but it may not be much different than for the rest of us. If the mouth or gut is affected, then the key is to find foods the patient can tolerate. Sometimes simple, easy to digest foods are best. If a GVHD patient requires corticosteroid treatment (prednisone) then a healthy diet should be balanced by exercise to prevent weight gain and loss of muscle mass. ...Read more

Dr. Benjamin Lerner Dr. Lerner
<b>4</b> doctors agreed:
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Managing Peripheral Vascular Disease (Checklist)

Try to continue walking
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Make sure that your risk factors, such as blood pressure and cholesterol, are addressed
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Inspect your feet daily, and call your medical doctor if you experience any wounds
Daily
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Are there any new treatments or drugs that can help with graft versus host disease?

Mainstays of therapy: for GVHD are corticosteroids; either systemic (prednisone) or topically, e.g triamcinolone. Cyclosporine and tacrolimus help minimize corticosteroid exposure. Sirolimus and mycophenylate mofetil are effective, as are methotrexate and azathioprine in refractory cases. B-cell therapies such as rituximab and bortezomib are promising. PUVA and ECP are light therapies with less systemic side effects. ...Read more

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Looking for top specialist for overlapping graft vs host disease. Husband suffering from steroid refractory skin gvhd. Nothing works. ?

Looking for top specialist for overlapping graft vs host disease. Husband suffering from steroid refractory skin gvhd.  Nothing works. ?

GvHD can be: Challenging. Photophoresis can be a nice adjunct if is available at your treatment center. This is a complex area and details of past therapy needed to give specific thoughts. ...Read more

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Is it typical to get graft vs. host digestive problems in first 90 days after bone marrow transplant? How does this affect long term prognosis?

Yes: It can happen within first 3 months or after. Graft vs host disease that is not too severe can be a sign of the graft vs leukemia effect but severe gvhd can itself cause mortality. ...Read more

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Living with Celiac Disease (Checklist)

Schedule a visit with a dietitian
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When eating out, inform your waitstaff you are intolerant of gluten
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What other diseases/infections am I at risk for when getting a cadaver tendon graft? (I know the chances are very low, I would still like to know)

Hepatitis: There's talk of both B and C having been transmitted. Nobody knows whether West Nile, prion disease, or HTLV-I or HTLV-2 can be transmitted. ...Read more

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Wanted to know if dental bone grafts work for peridontal disease?

Wanted to know if dental bone grafts work for peridontal disease?

Usually does...: Bone grafting is indicated for loose teeth due to a periodontal disease, but the teeth would have to be free of infection and stabilized with a fixed splint if the graft is to be successful. ...Read more

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Dr. Jessica Allan Dr. Allan
<b>1</b> doctor agreed:
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Living with Crohn's Disease (Checklist)

Find a gastroenterologist and follow their treatment regiment
Once
Stop smoking
Once
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Is it true that with bone grafting, all-on-four and etc, mostly anyone can get dental implants even if they lost teeth from gum disease?

Is it true that with bone grafting, all-on-four and etc, mostly anyone can get dental implants even if they lost teeth from gum disease?

Limitations: There are limitations to all treatments. For example, you can get periodontal disease around implants. Please see your Dentist for an evaluation as to whether implants and crowns or implant supported dentures would be applicable for your situation. Your Dentist may recommend teaming with an Oral Surgeon or Periodontist, or may recommend that you see a Prosthodontist. Go for exam and advice. ...Read more

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Dr. Matthew Majzun
20 doctors shared insights

Interstial Lung Disease (Definition)

Interstitial lung disease is a group of various conditions that affect the thin tissue between the airspaces in the lung. These disorders lead to thickening, fibrosis & scarring of the lung over time, making it difficult for patients to breathe. They can be caused by exposure to environmental toxins, certain drugs, infections, autoimmune disorders, genetic problems ...Read more


Dr. Tracy Lovell
526 doctors shared insights

Autoimmune Disease (Definition)

In auto immune disease the enemy is from with in . As name implies "auto" is self and "immune " is immune system . One 's own immune system for unknown reason turns against self and destroys or damages tissues or cells . List of auto immune disease are many and growing . End result is destruction of of tissues such as thyroid , pancreas or cells such as white ...Read more