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Doctor insights on: Gm Csf Allergy

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2.8 oligoclonal bands IgG in CSF. Zero serum bands in CSF. Why does Mayo Clinic standards require 4 oligoclonal IGg CSF for MS diagnosis?

2.8 oligoclonal bands IgG in CSF. Zero serum bands in CSF.  Why does Mayo Clinic standards require 4 oligoclonal IGg CSF for MS diagnosis?

Other causes: Oligoclonal bands can be present in some other conditions such as infections and inflammation of the central nervous system. Increasing the threshold for diagnosing MS by requiring at least 4 oligoclonal bands, allows to exclude these other causes and diagnose MS with greater certainty. ...Read more

Dr. John Chiu
2,689 doctors shared insights

Allergies (Definition)

Allergies occur when your immune system is triggered by envirionmental factors it should ignore--for example, pollen in the air, or dander on a cat or dog--and creates cells to fight against them. An allergic reaction typically causes itching, congestion, or drainage, and ...Read more


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Treating Skin Allergies (Checklist)

Use hydrocortisone
2x day
Do not use diphenhydramine topical cream
once
Avoid the offending agent (s)
once
Find out if you are allergic to nickel, as nickel is often the cause of skin allergies
once
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LP Done. Monocytes 1%, Serum IgG 587/mg/DL,Albumin 4100ml,IGG Index 1.1mg,WBC 23/mm3,RBC 1/mm3, CSF IGG 3.6 mg/DL,Lymphocytoid 97%, protein, neutrophils, glucose, CSF albumin all norm. Any ideas?

LP Done. Monocytes 1%, Serum IgG 587/mg/DL,Albumin 4100ml,IGG Index 1.1mg,WBC 23/mm3,RBC 1/mm3, CSF IGG 3.6 mg/DL,Lymphocytoid 97%, protein, neutrophils, glucose, CSF albumin all norm. Any ideas?

CSF Results: If I am reading the results correctly, there appears to be a mononuclear pleocytosis with normal protein, glucose and essentially normal immune response. The fluid analysis cn be seen in many disorders including viral meningitis. Need additional information. ...Read more

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Is there CSF IgG subclass deficiency? I have lowish IgG and IgG subclass deficiencies (1, 3, 4) and CSF IgG of 685 .

Is there CSF IgG subclass deficiency? 
I have lowish IgG and IgG subclass deficiencies (1, 3, 4)  and CSF IgG of 685 .

Csf labs: Lab values for cerebrospinal fluid tests must be interpreted in the context of the symptoms and signs and the time course, as well as imaging information. Your question cannot be answered in isolation. Please consult a neurologist. ...Read more

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What causes low csf glucose, high csf monocytes ?

What causes low csf glucose, high csf monocytes ?

TB: This is not a suitable topic for this forum, as a proper diagnosis would require a whole lot additional information. TB meningitis can produce this picture. See this site for more info. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335590/ ...Read more

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Igg synthesis (csf +serum) 20.1, IgG index 1.86, albumin CSF 11.8 , IgG CSF 6.4 , IgG 1080 , albumin 3.7, protein 34 and glucose 54 what do they mean?

Igg synthesis (csf +serum) 20.1, IgG index 1.86, albumin CSF 11.8 , IgG CSF 6.4 , IgG 1080 , albumin 3.7, protein  34 and glucose 54 what do they mean?

Lab Values: These are results from CSF (cerebral spinal fluid) tests that identify values that tell your physician whether you have normal or abnormal levels of Immune Globulin (igg), whether the ratio compared to your blood is correct; adequate protein(albumin) and sugar in the csf. All of these help to diagnose what type of problem may be occurring in your body and nervous system especially. ...Read more

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Do i worry for repeat, non anaphalatic unicap tryptase 15? And mature tryptase <1; IgE 28; occasional low WBC & neutrophils, asthma, itch, allergies?

Do i worry for repeat, non anaphalatic unicap tryptase 15?  And mature tryptase <1; IgE 28; occasional low WBC & neutrophils, asthma, itch, allergies?

Very unclear: You need further evaluation and clarification regarding the significance of your test results. Schedule appointment with your doctor and present you questions for specific answers. ...Read more

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Lumbar puncture results: Multiple IgG oligoclonal bands detected in CSF and serum, most bands unique to CSF. IgG value 9.43, range 6 - 15 Is this MS?

Consistent: But diagnosis of MS should be based on history, physical exam, results of MRI films, and spinal fluid is useful in ambiguous cases. However, elevation of oligoclonal bands can be seen in several disorders and NOT definitive on its own. Have your doctor now put the whole picture in place. Most likely MS, but other possibilities exist. ...Read more

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Gamma Globulin 1.8 slightly high The rest normal. No M-protein spike. IGE Serum 151 H IgG 1768 H What could cause these results...

Gamma Globulin 1.8 slightly high
The rest normal.
No M-protein  spike.
IGE Serum 151 H
IgG 1768 H 
What could cause these results...

Reassurance : You just have very high immunity. All this number show a very good defense mechanism. Sometimes the questions is: from what? May be your doctor can answer that question. ...Read more

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2 yrs rhinitis symptoms. Tried steroid sprays, allergy meds, scans, reflux, the lot! One possibility: v.high IgE Total on allergy blood test. Ideas?

2 yrs rhinitis symptoms. Tried steroid sprays, allergy meds, scans, reflux, the lot! One possibility: v.high IgE Total on allergy blood test. Ideas?

Treatment: There are several potential causes for rhinitis. In this case, high IgE is suggestive of allergy to environmental triggers (but in no way clearly diagnostic). More information is needed in order to suggest a specific strategy (eg allergy shots or immunotherapy), but no matter the cause; rest assured that we have options. ...Read more

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Can you explain my lumbar puncture results - CSF alpha Feto protein 0.555 Beta HCG 0.322(iu/l) I have a pineal tumour. Tested CSF for germ cell.

These values are OK: These levels do not look out of ordinary. You need to relate these levels to previous levels of these markers. if they were high before then this test might have some meaning. Your oncologist is your best guide to explain what it all means. ...Read more

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What does having an elevated CSF protein level of 87 mean?

What does having an elevated CSF protein level of 87 mean?

CSF protein: An elevated CSF protein cannot be taken out of context without knowing the cell count and glucose. Overall, the CSF protein does increase somewhat with age and in diabetics. ...Read more

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How effective are monoclonal IgE blockers in allergic rhinitis?

How effective are monoclonal IgE blockers in allergic rhinitis?

IgE antibodies : Theoretically, one would expect monoclonal IgE antibodies to be very effective in blocking the allergic response. In the US, this has not been rigorously tested to establish its effectiveness. It is not FDA approved therapy at this time. However, it is approved for IgE mediated asthmatic disease and can concomitantly help allergic rhinitis in those patients. ...Read more

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Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

False positive rate: There is 30% or so false positive rate of kappa/lambda ratio in people without MGUS, myeloma or other disorders. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more

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What can a LP high protein CSF level of 46 mean?

What can a LP high protein CSF level of 46 mean?

Many causes: CSF protein results can be high in many conditions. It is best to interpret the results in the context of all the other results of CSF fluid analysis. Some causes are viral meningitis, demyelinatinfg diseases, diabetes, brain abscess, syphillis, brain tumor, alcoholism, and epilepsy ...Read more

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Allergist said if cholinergic urticaria doesn't improve, take 20 mg Zyrtec; Max limit is 20 mg zyrtec + 1 tab 180mg allegra (fexofenadine). Safe? is it okay?

Allergist said if cholinergic urticaria doesn't improve, take 20 mg Zyrtec; Max limit is 20 mg zyrtec + 1 tab 180mg allegra (fexofenadine). Safe? is it okay?

Yes: Yes, these doses of antihistamines are safe. But make sure you stay hydrated (drink lots of water throughout the day while on this dose). ...Read more

Cerebrospinal Fluid (Definition)

The fluid that bathes the brain and spinal cord provides an exchange pathway and balancing system for brain and spinal cord metabolism, besides a cushioning system for routine impacts of our ...Read more


Csf (Definition)

Cerebrospinal fluid is the clear colorless fluid produced in the choroid plexus in the brain, and acts as a cushion or a buffer for the ...Read more