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Doctor insights on: Fluorescence In Situ Hybridization Cml All Bcr Abl Trans 9 22

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Can chronic myelogenous leukemia (bcr/abl) have any effect on cellular metabolism?

Can chronic myelogenous leukemia (bcr/abl) have any effect on cellular metabolism?

Why this question???: Unless you are doing some research yourself, this question has zero relevance for your/anyone's treatment for cml. So let us keep life simple and straightforward and not complicate it for all of us who are trying to help patients in desperate need for quick and simple guidance! ...Read more

In Situ (Definition)

Means localosed in place. Medical terms is for carcinoma "localized and did not spread out" it is really description of precancerous condition with bad name that disturbs many patients. Carcinoma in situ is not a killer. If left untreated will develop into invasive cancer ...Read more


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If a person had bcr-abl in low amount in blood. Do they have cml?

Maybe not: It depends on the test. With fish a few positive cells out of 200 can be expected based on overlapping signal and the way the test is done. If the technique was pcr very low level positives have been seen in people without cml. ...Read more

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Years of persistent unknown luekocytosis(15-25k)&thrombosis(465-525).Jak2 and bcr-abl=negative. Et? Or what kind of "hidden" issue could be causative?

Years of persistent unknown luekocytosis(15-25k)&thrombosis(465-525).Jak2 and bcr-abl=negative. Et? Or what kind of "hidden" issue could be causative?

Many: There are many causes of this picture. Perhaps the most common is hidden infection or inflammation and iron deficiency. Other causes include chronic myeloid leukemia with other rare mutation, chronic neutrophilic leukemia, myelofibrosis, etc. You probably would benefit from hematology consultation. Lap score many be useful as well. ...Read more

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In Bone marrow test BCR-ABL Translocation ratio is 56.31% is it serious condition or not please provide the corresponding treatment for the result?

In Bone marrow test BCR-ABL Translocation ratio is 56.31% is it serious condition or not  please provide the corresponding treatment for the result?

CML: Refer your test report for interpretation. This usually indicates a positive BCR-ABL translocation, specific for the diagnosis of CML (chronic myelogenous leukemia) in the right clinical presentation. CML is a very treatable disease now with oral pills such as Gleevec, Tasigna, (nilotinib) and Sprycel with very high response rate. Good luck! Of note, this can also occur in ALL. ...Read more

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WBC Count is high,BCR-ABL Translocation ratio is 56.31% in bone marrow test. what is the exact problem? Please provide the solution

WBC Count is high,BCR-ABL Translocation ratio is 56.31% in bone marrow test. what is the exact problem? Please provide the solution

Demand an answer: You have chronic granulocytic leukemia or one of its close relatives and you should have been told. There's no "solution" in terms of an easy cure, but this is a manageable illness. You owe it to yourself both to get the full picture from your physicians, and read up on this family of illnesses and the treatment options -- medication versus (at your young age) possible curative transplant Rx. ...Read more

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Have low platelet, splenomegaly,high LDH, B2M and C-reactive protein, normal marrow, cytometry and pet scan,normal WBC, possible CML? fish ?PCR need?

Autoimmune: Sounds like the good news is cancer had been ruled out. The tests and physical problems you listed can have many causes. Infections especially viral, are a cause. Medications or environmental exposures are possible. Autoimmune diseases are also a big possibility. Your next step should be a rheumatologist. ...Read more

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What's the type of inheritance of chronic myelogenous leukemia (cml)?

Not inherited: CML is associated with chromosome damage (the philadelphia chromosome). This is not inherited. The damage is to bone morrow stem cells and occurs long after birth. So the disease is not passed on to children. ...Read more

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What is chronic myelogenous leukemia (cml)?

What is chronic myelogenous leukemia (cml)?

White cell cancer: The bone marrow cells that produce granulocytes (needed to fight infections) grow out of control and are present in large numbers in the blood and other organs. The disease is quite treatable these days because of targeted therapy and long lasting remissions are possible in most people. ...Read more

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What sort of disease is chronic myelogenous leukemia (c.M.L.)?

Bcr-abl: CML is a clonal disorder (cancer) of the white blood cells in the blood (= -emia part). Other leukemias include cll, aml, all, etc. CML is often diagnosed by testing on peripheral blood or bone marrow. The bcr-abl translocation (philadelphia chromosome) is found in cml. Treatment may be a variety of pills. The most common initial treatment has been gleevec (imatinib). Other drugs are available. ...Read more

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What complications arise when a person with chronic myelogenous leukemia (cml) becomes pregnant?

What complications arise when a person with chronic myelogenous leukemia (cml) becomes pregnant?

Difficult situation: This has happened to many women taking Imatinib (Gleevec) for CML. Most women have had a normal baby, others aborted the baby with help from a Gynecologist. I believe it is safe to carry the baby to term but there is some risk the drugs can harm the bay but it is not proven. So if you want to keep the baby then you should take this risk, but be closely monitored by a CML expert. First 3 months are ...Read more

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What are different ways to treat chronic myelogenous leukemia?

What are different ways to treat chronic myelogenous leukemia?

CML: CML is associated with philadelphia chromosome that result in the abnormal bcr-abl fusion gene. This becomes the target of treatment in cml. Oral tyrosine kinase inhibitor (tki) is the treatment of cml. The 1st generation is gleevec. Other tki that is more specific to block the bcr/abl fusion gene also available- sprycel and tasigna (nilotinib). Bone marrow transplant is available only for specific case. ...Read more

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What is the definition or description of: Chronic myelogenous leukemia?

CML: there are two types of CML ,juvenile and adult . each manifests marked clinical , hematological,and cytogenetic differences. ...Read more

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What's the genotype of chronic myelogenous leukemia?

9-22 translocation: A portion of chromosome 9 is tranferred to chromosome 22...When a cytogeneticist looks at this...They see the characteristic "philodephia chromosome" named after the city where the research was conducted. ...Read more

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Can chronic myelogenous leukemia affect cellular metabolism?

It is Complex!: Why is it so important to know the answer to this question for your practical purpose and guidance, it does not. But if you want to conduct research on this matter be my guest! ...Read more

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What happens genetically that causes chronic myelogenous leukemia?

What happens genetically that causes chronic myelogenous leukemia?

Translocation: A big word but dna is always recombining when cells divide. In this case, a piece of dna from chromosome 9 moves over to chromosome 22 which essentially turns on a switch that produces an enzyme that promotes uncontrolled cell division and leukemia. Modern drugs are targeted to prevent the action of this enzyme. ...Read more

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What is chronic myelogenous leukemia?

A blood cancer: CML is a blood cancer that develops slowly (hence chronic). If untreated it will eventually be life threatening. It is associated a unique chromosomal injury, the philadelphia chromosome. New drugs (tkis) target this damage and reliably produce remissions in early stage patients that often are long lasting. ...Read more

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Dangers of chronic myelogenous leukemia?

Can be fatal: This is a disease that was associated with a shortened life span. The discovery of a specific cancer cell mutation and medications that attack that mutation have dramatically affected the outcome. This is now a disease that people can live for many years and be functional and productive. ...Read more

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How should I treat chronic myelogenous leukemia?

How should I treat chronic myelogenous leukemia?

By oncologist: This is a somewhat indolent form of leukemia which responds to treatment and can be carried for many years without major illenss. You could only have known about this if you had a bone marrow and blood test from your oncologist whose recommendations i would continue to follow. ...Read more

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What are the tests for chronic myelogenous leukemia?

What are the tests for chronic myelogenous leukemia?

Blood, bone marrow: Common tests include blood review, floww cytometry, and a bone marrowe and biopsy. ...Read more

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Dr. Julio Hajdenberg
58 doctors shared insights

Cml (Definition)

Chronic myelogenous leukemia (CML), is a type of blood cancer where the slow overgrowth of the immune cells of the blood leads to a weakened immune system, lymph node and spleen enlargement, fatigue from anemia, and ...Read more


Dr. Liawaty Ho
60 doctors shared insights

Chronic Myelogenous Leukemia (Definition)

there are two types of CML ,juvenile and adult . each manifests marked clinical ...Read more