Doctor insights on:
Fluorescence In Situ Hybridization Cml All Bcr Abl Trans 9 22
Why this question???: Unless you are doing some research yourself, this question has zero relevance for your/anyone's treatment for cml. So let us keep life simple and straightforward and not complicate it for all of us who are trying to help patients in desperate need for quick and simple guidance! ...Read more
Means localosed in place. Medical terms is for carcinoma "localized and did not spread out" it is really description of precancerous condition with bad name that disturbs many patients. Carcinoma in situ is not a killer. If left untreated will develop into invasive cancer ...Read more
After a stem cell transplant 15 years ago, my BCR-ABL blood test is again positive for CML.
What do you suggest as the best medication on the market?
Oncologist: I suggest which ever medications your oncologist recommends. ...Read more
Years of persistent unknown luekocytosis(15-25k)&thrombosis(465-525).Jak2 and bcr-abl=negative. Et? Or what kind of "hidden" issue could be causative?
Many: There are many causes of this picture. Perhaps the most common is hidden infection or inflammation and iron deficiency. Other causes include chronic myeloid leukemia with other rare mutation, chronic neutrophilic leukemia, myelofibrosis, etc. You probably would benefit from hematology consultation. Lap score many be useful as well. ...Read more
In Bone marrow test BCR-ABL Translocation ratio is 56.31% is it serious condition or not please provide the corresponding treatment for the result?
CML: Refer your test report for interpretation. This usually indicates a positive BCR-ABL translocation, specific for the diagnosis of CML (chronic myelogenous leukemia) in the right clinical presentation. CML is a very treatable disease now with oral pills such as Gleevec, Tasigna, (nilotinib) and Sprycel with very high response rate. Good luck! Of note, this can also occur in ALL. ...Read more
WBC Count is high,BCR-ABL Translocation ratio is 56.31% in bone marrow test. what is the exact problem? Please provide the solution
Demand an answer: You have chronic granulocytic leukemia or one of its close relatives and you should have been told. There's no "solution" in terms of an easy cure, but this is a manageable illness. You owe it to yourself both to get the full picture from your physicians, and read up on this family of illnesses and the treatment options -- medication versus (at your young age) possible curative transplant Rx. ...Read more
Have low platelet, splenomegaly,high LDH, B2M and C-reactive protein, normal marrow, cytometry and pet scan,normal WBC, possible CML? fish ?PCR need?
Autoimmune: Sounds like the good news is cancer had been ruled out. The tests and physical problems you listed can have many causes. Infections especially viral, are a cause. Medications or environmental exposures are possible. Autoimmune diseases are also a big possibility. Your next step should be a rheumatologist. ...Read more
White cell cancer: The bone marrow cells that produce granulocytes (needed to fight infections) grow out of control and are present in large numbers in the blood and other organs. The disease is quite treatable these days because of targeted therapy and long lasting remissions are possible in most people. ...Read moreSee 1 more doctor answer
Bcr-abl: CML is a clonal disorder (cancer) of the white blood cells in the blood (= -emia part). Other leukemias include cll, aml, all, etc. CML is often diagnosed by testing on peripheral blood or bone marrow. The bcr-abl translocation (philadelphia chromosome) is found in cml. Treatment may be a variety of pills. The most common initial treatment has been gleevec (imatinib). Other drugs are available. ...Read more
Difficult situation: This has happened to many women taking Imatinib (Gleevec) for CML. Most women have had a normal baby, others aborted the baby with help from a Gynecologist. I believe it is safe to carry the baby to term but there is some risk the drugs can harm the bay but it is not proven. So if you want to keep the baby then you should take this risk, but be closely monitored by a CML expert. First 3 months are ...Read more
CML: CML is associated with philadelphia chromosome that result in the abnormal bcr-abl fusion gene. This becomes the target of treatment in cml. Oral tyrosine kinase inhibitor (tki) is the treatment of cml. The 1st generation is gleevec. Other tki that is more specific to block the bcr/abl fusion gene also available- sprycel and tasigna (nilotinib). Bone marrow transplant is available only for specific case. ...Read moreSee 1 more doctor answer
9-22 translocation: A portion of chromosome 9 is tranferred to chromosome 22...When a cytogeneticist looks at this...They see the characteristic "philodephia chromosome" named after the city where the research was conducted. ...Read more
It is Complex!: Why is it so important to know the answer to this question for your practical purpose and guidance, it does not. But if you want to conduct research on this matter be my guest! ...Read more
Translocation: A big word but dna is always recombining when cells divide. In this case, a piece of dna from chromosome 9 moves over to chromosome 22 which essentially turns on a switch that produces an enzyme that promotes uncontrolled cell division and leukemia. Modern drugs are targeted to prevent the action of this enzyme. ...Read moreSee 1 more doctor answer
A blood cancer: CML is a blood cancer that develops slowly (hence chronic). If untreated it will eventually be life threatening. It is associated a unique chromosomal injury, the philadelphia chromosome. New drugs (tkis) target this damage and reliably produce remissions in early stage patients that often are long lasting. ...Read moreSee 1 more doctor answer
Can be fatal: This is a disease that was associated with a shortened life span. The discovery of a specific cancer cell mutation and medications that attack that mutation have dramatically affected the outcome. This is now a disease that people can live for many years and be functional and productive. ...Read more
By oncologist: This is a somewhat indolent form of leukemia which responds to treatment and can be carried for many years without major illenss. You could only have known about this if you had a bone marrow and blood test from your oncologist whose recommendations i would continue to follow. ...Read moreSee 2 more doctor answers
Sure, i've heard of chronic myelogenous leukemia. But now that I have it, I want to know what is really happening in my body.?
Cancer of WBC: CML is a chronic leukemia- cancer of the white blood cells. The bad news is that you have cancer. The good news is that you can control-perhaps to "cure" this leukemia with pill that you take at daily basis. The prognosis majority is very good. Only for a few cases-that people need bone marrow transplantation for cml- nowadays. For further detail info- read at www.Nccn.Com for patient resource. ...Read moreSee 1 more doctor answer
Multiple: There are medications called tyrosine kinase inhibitors. They block this enzyme and treat the leukemia. There are currently three on the market, imatinib, nilotinib and dasatinib. Other treatments include bone marrow transplant but rarely done now because these medications are available. Hope this helps. ...Read moreSee 1 more doctor answer
Usually: Holistic doctors so not have any magic cures for CML but they can help you handle the stress of having a chronic illness, reduce your body's load of toxins, optimize your nutritional status ; immune funtion, support and protect your body from adverse side effects of chemotherapy and give advice on complementary natural therapies such as herbs and homeopathy. This can be very helpful, . ...Read more
I live in a college town with many healers who use Asian treatments. Will they work on chronic myelogenous leukemia?
High deductible. Limited coverage of outpatient care. Would really help to know what tests, evaluations are required to diagnose chronic myelogenous leukemia and follow it after treatment.?
Nccn.org: Awful predicament. CML is one of the success stories with the new therapies, but proper follow up is important to assure optimal long term survival on the new oral agents. There are good patient assistance programs to assist with your medications. Review the web address above and CML page with your doc to plan the needed tests. ...Read more
CBC showed high Neutrophils and MPV, should I be worried about Chronic myelogenous leukemia? I have several symptoms that may suggest it's a posibilit
Need to examine:
All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Talk to the doctor who ordered the tests. Having said that, it would have helped to have the actual values rather than "high".
Wish you good health! - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex, if you have sex. ...Read more
Need to see all the : Results. How high is the count? What does the blood smear look like? A mild elevation of monocytes probably is not indication of any disease. Please note that all lab results need to be interpreted in the clinical context and your doctor is in the best position to do that. ...Read more
Very good: Most people diagnosed with CML today are treated with imatinib or a similar drug like nilotinib or desitanib. These medications will often put people into remission. If you obtain a cytogenetic/molecular and hematologic remission people often live for years. The biggest risk is transformation to an aggressive leukemia, though this does not frequently occur. Many factors determine prognosis. ...Read more
Sure: Nowadays this is quite manageable in most cases. If you choose to drink, do it wisely. ...Read more
Ask your doctor: Such questions are better explained by your treating doctor, but you have to ask them him/hr. Your WBC count is still a bit high. It is easy to get CML into remission which means a WBC count of < 10, 000 and disappearance of your genetic abnormality which is called philadelphia chromosome. The modern treatments are also expected to produce a molecular remission...Ask your doctor about what you hav. ...Read more
Yes : CML used to be bad, 50% dead in 5 years. Today treatment with tyrosine kinase inhibitors results in 95% of patients being alive 5 years after diagnosis. So far, treatment with tkis does not seem to permanently eliminate the leukemia, requiring continued rx. A smaller proportion of patients who fail tki rx can get transplants and be truly cured, but at the risk of complications. See a good hem/onc! ...Read more