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Doctor insights on: Diphenhydramine

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Dr. John Chiu
1,049 doctors shared insights

Diphenhydramine (Overview)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common cold or symptom drug).


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What amount diphenhydramine is an overdose?

What amount diphenhydramine is an overdose?

It depends: Diphenhydramine was a major cause of seizures reported to a poison center. At a dose of 7.5mg/Kg (a total dose of 500 mg [20 OTC tablets] for a 150 pound person) many p0eople will develop severe reactions. In doses over 1g (40 tablets) the drug may be lethal. ...Read more

Dr. John Chiu
1,049 doctors shared insights

Diphenhydramine (Overview)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common cold or symptom drug).


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Can you really die from an overdose of diphenhydramine?

Can you really die from an overdose of diphenhydramine?

Yes.: There are numerous studies & case reports in the medical literature of deaths due to either accidental or intentional overdoses of Diphenhydramine (benadryl). The drug has a high therapeutic index meaning the dose needed to cause death is many times higher than that needed to produce beneficial effects. Its always a good idea to be cautious with all drugs - prescribed, otc, herbal or homeopathic. ...Read more

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Can you please describe the effects and factors of taking over 22 pills of diphenhydramine hci 25 mg?

Can you please describe the effects and factors of taking over 22 pills of diphenhydramine hci 25 mg?

Wow: Is this a suicidal attempt? If so , see a psychiatrist asap. The short answer would be excessively dry mouth, fast heart rate, constipation, urinary retention, and drowsiness from its anticholinergic actions. ...Read more

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Can people that have heart bypass surgery use diphenhydramine?

Yes: Benadryl
invented by dr george rieveschl of cincinnati
is an incredibly safe drug. ...Read more

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Using diphenhydramine(50mg pill) for sleep I have a high tolerance, I'm a 22 yr old female 111lbs. Would 100mg be ok since 50mg doesn't work?

Using diphenhydramine(50mg pill) for sleep I have a high tolerance, I'm a 22 yr old female 111lbs. Would 100mg be ok since 50mg doesn't work?

No: Regardless of your tolerance, 100 mg of Benadryl (diphenhydramine) is not a safe or studied dose. You can still experience slowing of reflexes and thought processes even if you do not feel sleepy with Benadryl (diphenhydramine). You should see a sleep specialist to help you with your insomnia. ...Read more

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Is it safe to take diphenhydramine after surgery?

Is it safe to take diphenhydramine after surgery?

Most likely: Benedryl is pretty innocuous. If you happen to have some itching or allergy reaction from any of your surgery meds or dressings, you may take it. Same if you need sleep and just need the benedryl for sedation. Take your other medications as prescribed, and let your surgeon about any other meds you are taking, just to keep him/her informed. ...Read more

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Sure death from diphenhydramine overdose?

Sure death from diphenhydramine overdose?

Benadryl (diphenhydramine) overdose: Benadryl (diphenhydramine) overdose is highly toxic, potentially fatal, and their is no known antidote. Death would depend on the dose taken and the time it takes to get definitive care (like having stomach pumped and IV fluids). ...Read more

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What is the lethal dose of diphenhydramine for a 110 pound woman?

Therapeutic dose: The therapeutic dose is 1mg/kg. Would be ~ 50mg. ...Read more

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What are the side effects of diphenhydramine?

What are the side effects of diphenhydramine?

Several: The most common side effect of taking too much Benadryl (diphenhydramine) would be excessive drowsiness. Other possible side effects include dizziness, headache, constipation, urinary retention, and heart palpitations. ...Read more

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Yesterday around 4 am after a night of drinking i took 125mg of diphenhydramine hci to help me sleep. How long till it is out of my system?

Risky business: Theoretically, the half-life of Benadryl (diphenhydramine) is 8 hours. But you took. A whopping dose, a real benadryl-alcohol mickey finn. That can lead to dizziness, drowsiness ; potential overdose. Don't drive till you're sure you're alert. Btw, i hope you don't choose to do this to yourself again. Drugs ; drinking don't mix. We don't want you to join the " 29 club"! ...Read more

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How long would alcohol stay in your system? How long would I have to wait until I could take diphenhydramine as a sleep aid after my last drink?

How long would alcohol stay in your system? How long would I have to wait until I could take diphenhydramine as a sleep aid after my last drink?

Depends: Alcohol elimination depends on various factors including concomitant food consumption, other comorbidities, etc. Diphenhydramine is another sedating drug and isn't recommended to be taken with alcohol. See your physician for a full discussion. http://www.nlm.nih.gov/medlineplus/alcohol.html ...Read more

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Do Benadryl (diphenhydramine) and Adderall interact with each other?

Do Benadryl (diphenhydramine) and Adderall interact with each other?

Drug interactions.: Benadryl (diphenhydramine) can be sedating (typically) or stimulating (unusual) . When a reaction occurs opposite to what is typically experienced, it is called a paradoxical reaction. A pharmacist can run a drug interaction screen for you and this is why it is wise to get all of your medications from a single source. Decongestants are stimulants and often used in combination with Benadryl (diphenhydramine) and could be a bad mix. ...Read more

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Are there any interactions between diphenhydramine and l-theamine? Can both be taken together safely in recommended amounts for sleep?

Are there any interactions between diphenhydramine and l-theamine? Can both be taken together safely in recommended amounts for sleep?

No: I am not sure what l-theanine is. However, the only dietary supplements/herbals i know of which should be avoided when taking Diphenhydramine are valerian, st. John's wort, kava kava, and gotu kola; as the combination may enhance CNS depression. I am doubtful that whatever l-theanine is will compound any sedative effects you may experience with Diphenhydramine alone. ...Read more

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Is it safe to mix diphenhydramine with dimenhydrate?

Is it safe to mix diphenhydramine with dimenhydrate?

I wouldn't. : They are very similar drugs and closely related chemically. Their side effects are identical and would be additive if you took the two together. ...Read more

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Is taking 200mg of diphenhydramine too much to fall asleep? I have not even been able to sleep well with that amount but afraid to take more.

Dose is too high: That dosage is a bit high and any additional probably won't add any additional sedative value. I would suggest other alternatives, such as doxylamine or prescription strength hypnotics. Also a natural alternative melatonin does help improve sleep cycles, while not short term effective may prove to help in the longer term. An evaluation of sleep patterns also may help. Napping/evening foods, etc. ...Read more

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Is diphenhydramine adictave?

No: The antihistamine is does not have addictive qualities. Yet a person can become habit driven to continue any product/medication/coffee/food etc.Habituation is a strong force in ones life to continue past patterns. If stopped, a longing for that product can be quite strong, but it does not produce the physical addiction entails. ...Read more

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Can i cut diphenhydramine in half?

Can i cut diphenhydramine in half?

Depends: Some Diphenhydramine comes in capsules and some in solid pills. You can cut the pills but the capsules will just squish, break open and spill the contents. If capsules are all you have, you can dissolve the contents in water and drink half or something we do with patients at times is to mix it with jello and have them eat the proper amount. ...Read more

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Is 150 mg of diphenhydramine okay?

too much: This is too much diphenhydramine, you should not take such high doses before checking with a doctor or guided by a doctor. ...Read more

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Can i cut a diphenhydramine in half?

Tabs, yes: It is not practical to cut a capsule, but a scored tablet can be easily cut with a pill cutter. There are many formulations of Diphenhydramine in case a lower than usual dose is required. ...Read more

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What color are diphenhydramine pills?

DiphenhydramineColor: Usually they are pink or pink and white if capsules; but I do not know if soem generic version scould be white. ...Read more

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Can I take 75mg of Diphenhydramine HCI?

Probably but why?: Adult dosing is 25-50 mg every 4-6 hours as needed. Maximum dosing is listed as 100mg per dose up to a total of 300 to 400mg per day. I'm just wondering your reason for taking 75mg, as this medicine is sedating, and can make you sleepy. If the 25-50 mg isn't strong enough, maybe there's something else better for you to try. Discuss this with your doctor, who might have a better suggestion for you. ...Read more

Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more