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Doctor insights on: Diphenhydramine

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Dr. John Chiu
1,047 doctors shared insights

Diphenhydramine (Overview)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common cold or symptom drug).


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What amount diphenhydramine is an overdose?

What amount diphenhydramine is an overdose?

It depends: Diphenhydramine was a major cause of seizures reported to a poison center. At a dose of 7.5mg/Kg (a total dose of 500 mg [20 OTC tablets] for a 150 pound person) many p0eople will develop severe reactions. In doses over 1g (40 tablets) the drug may be lethal. ...Read more

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Dr. John Chiu
1,047 doctors shared insights

Diphenhydramine (Overview)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common cold or symptom drug).


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Can you really die from an overdose of diphenhydramine?

Can you really die from an overdose of diphenhydramine?

Yes.: There are numerous studies & case reports in the medical literature of deaths due to either accidental or intentional overdoses of Diphenhydramine (benadryl). The drug has a high therapeutic index meaning the dose needed to cause death is many times higher than that needed to produce beneficial effects. Its always a good idea to be cautious with all drugs - prescribed, otc, herbal or homeopathic. ...Read more

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Can you please describe the effects and factors of taking over 22 pills of diphenhydramine hci 25 mg?

Can you please describe the effects and factors of taking over 22 pills of diphenhydramine hci 25 mg?

Wow: Is this a suicidal attempt? If so , see a psychiatrist asap. The short answer would be excessively dry mouth, fast heart rate, constipation, urinary retention, and drowsiness from its anticholinergic actions. ...Read more

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Can people that have heart bypass surgery use diphenhydramine?

Yes: Benadryl
invented by dr george rieveschl of cincinnati
is an incredibly safe drug. ...Read more

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Using diphenhydramine(50mg pill) for sleep I have a high tolerance, I'm a 22 yr old female 111lbs. Would 100mg be ok since 50mg doesn't work?

Using diphenhydramine(50mg pill) for sleep I have a high tolerance, I'm a 22 yr old female 111lbs. Would 100mg be ok since 50mg doesn't work?

No: Regardless of your tolerance, 100 mg of Benadryl (diphenhydramine) is not a safe or studied dose. You can still experience slowing of reflexes and thought processes even if you do not feel sleepy with Benadryl (diphenhydramine). You should see a sleep specialist to help you with your insomnia. ...Read more

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Is it safe to take diphenhydramine after surgery?

Is it safe to take diphenhydramine after surgery?

Most likely: Benedryl is pretty innocuous. If you happen to have some itching or allergy reaction from any of your surgery meds or dressings, you may take it. Same if you need sleep and just need the benedryl for sedation. Take your other medications as prescribed, and let your surgeon about any other meds you are taking, just to keep him/her informed. ...Read more

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Sure death from diphenhydramine overdose?

Sure death from diphenhydramine overdose?

Benadryl (diphenhydramine) overdose: Benadryl (diphenhydramine) overdose is highly toxic, potentially fatal, and their is no known antidote. Death would depend on the dose taken and the time it takes to get definitive care (like having stomach pumped and IV fluids). ...Read more

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What is the lethal dose of diphenhydramine for a 110 pound woman?

Therapeutic dose: The therapeutic dose is 1mg/kg. Would be ~ 50mg. ...Read more

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What are the side effects of diphenhydramine?

What are the side effects of diphenhydramine?

Several: The most common side effect of taking too much Benadryl (diphenhydramine) would be excessive drowsiness. Other possible side effects include dizziness, headache, constipation, urinary retention, and heart palpitations. ...Read more

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Yesterday around 4 am after a night of drinking i took 125mg of diphenhydramine hci to help me sleep. How long till it is out of my system?

Risky business: Theoretically, the half-life of Benadryl (diphenhydramine) is 8 hours. But you took. A whopping dose, a real benadryl-alcohol mickey finn. That can lead to dizziness, drowsiness ; potential overdose. Don't drive till you're sure you're alert. Btw, i hope you don't choose to do this to yourself again. Drugs ; drinking don't mix. We don't want you to join the " 29 club"! ...Read more

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How long would alcohol stay in your system? How long would I have to wait until I could take diphenhydramine as a sleep aid after my last drink?

How long would alcohol stay in your system? How long would I have to wait until I could take diphenhydramine as a sleep aid after my last drink?

Depends: Alcohol elimination depends on various factors including concomitant food consumption, other comorbidities, etc. Diphenhydramine is another sedating drug and isn't recommended to be taken with alcohol. See your physician for a full discussion. http://www.nlm.nih.gov/medlineplus/alcohol.html ...Read more

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Do Benadryl (diphenhydramine) and Adderall interact with each other?

Do Benadryl (diphenhydramine) and Adderall interact with each other?

Drug interactions.: Benadryl (diphenhydramine) can be sedating (typically) or stimulating (unusual) . When a reaction occurs opposite to what is typically experienced, it is called a paradoxical reaction. A pharmacist can run a drug interaction screen for you and this is why it is wise to get all of your medications from a single source. Decongestants are stimulants and often used in combination with Benadryl (diphenhydramine) and could be a bad mix. ...Read more

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Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more