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Doctor insights on: Cholestasis

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Dr. Ira Friedlander
79 Doctors shared insights

Cholestasis (Overview)

When the flow of bile (chole) is held back (stasis). It can be from the liver cells not moving it (often from medications), or from the biliary tree being plugged by stone, tumor, or scar.


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My wife has been diagnosed with cholestasis. How does this affect pregnancy?

My wife has been diagnosed with cholestasis. How does this affect pregnancy?

In bad way: Upon diagnosis, most providers will prescribe ursodeoxycholic acid. While there is no cure for for it, and no way to guarantee a successful outcome, studies have shown a slightly better fetal and maternal outcome from administration of ursodeoxycholic acid, whereas Cholestyramine appears to only relieve itching. Giving vit k during delivary.

Delivery by 37 completed weeks is considered crucial ...Read more

Dr. Ira Friedlander
79 Doctors shared insights

Cholestasis (Overview)

When the flow of bile (chole) is held back (stasis). It can be from the liver cells not moving it (often from medications), or from the biliary tree being plugged by stone, tumor, or scar.


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What causes cholestasis of pregnancy and what are the symptoms?

What causes cholestasis of pregnancy and what are the symptoms?

Itching & Jaundice: As well as elevated blood levels of bile acids. More common in scandinavia, south america, and multiple gestation pregnancy. An increased sensitivity of some women to the estrogen hormones of pregnancy lead to a reduced ability of their bodies to eliminate bile acids, causing them to accumulate. The condition usually resolves within 2-3 weeks of delivery. ...Read more

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Are yellow nails a sign of cholestasis I'm 38.4 weeks pregnant?

Not likely: It is highly unlikely that you are getting yellow nails from cholestasis without also having yellow eyes and skin. Also u would be having some itching as well from cholestasis of pregnancy. There is a condition called yellow nail syndrome which has nothing to do with gallbladder/liver disease. Check with your doc. Congrats on the pregnancy and good luck to you! ...Read more

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What exactly is cholestasis?

What exactly is cholestasis?

Bile flow: Usually means disruption (slowing or blockage) of bile flow from the liver. ...Read more

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Other than elevated liver enzyme levels, what other blood tests diagnose cholestasis?

Nothing: By definition it is a diagnosis of abnl blood work. That being said cholestatic changes can be seen with a liver biopsy. ...Read more

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What are the tests for intrahepatic cholestasis of pregnancy?

What are the tests for intrahepatic cholestasis of pregnancy?

LFTs, bile acids.: Liver function tests (alt/ast/alkaline phosphatase) and bile acids can clinch the clinical diagnosis of intrahepatic cholestasis of pregnancy - in the absence of cholelithiasis. ...Read more

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Can liver disease cause cholestasis?

Can liver disease cause cholestasis?

Sure, but...: Liver disease comes in many varieties and manifestations: cholestasis (either intrahepatic or extrahepatic) with jaundice; infiltrative (like fatty liver, amyloidosis); fibrotic (trending toward cirrhosis); congestive (blood backs up into the liver); ischemic; shock injury; toxic (either metabolic or drug-related); hepatitis (infectious or otherwise, the liver cells are sick); familial; cancer... ...Read more

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What does cholestasis mean?

What does cholestasis mean?

Bile flow: Usually means disruption (slowing or blockage) of bile flow from the liver. ...Read more

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What are tests, treatment for cholestasis of pregnancy?

What are tests, treatment for cholestasis of pregnancy?

Med, early delivery: Intrahepatic cholestasis is usually first noticed when a pregnant woman complains of itching all over the body but no rash. Testing will show abnormal bile salt levels and liver function tests. There is a medication that relieves the itching and lowers bile salt, but there is increased risk for stillbirth, so close monitoring of the pregnancy and delivery as soon as feasible is usual management. ...Read more

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Could I have icp (intrahepatic cholestasis of pregnancy)? What are the risks?

Icp causes itching: I have only had one patient with icp in 27 years of practicing obstetrics. Diagnosis is made by elevated bile salts (detectable by lab test) and the treatment is cholestyramine. Pregnancy outcome should be unaffected by the condition. So icp is rare and makes you miserable, but should not affect your baby. One case however hardly makes me an expert so second opinions welcome. ...Read more

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What are the chances of having cholestasis of pregnancy in consecutive pregnancies?

70% recurrance risk: Recurrance risk for cholestasis of pregnancy can be as high as 70% in subsequent pregnancies. There is no current therapy to lessen the risk or prevent those recurrances. ...Read more

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I have a kid and miscarried year ago. Want to get pregnant again. How should I prepare to avoid problems like cholestasis.?

High risk pregnany: Most likely cholestasis of pregnancy will reccur in future pregnancy. Establish care with an obstetrician who can manage high risk pregnancy. ...Read more

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What does cholestasis mean?

Bile flow: Usually means disruption (slowing or blockage) of bile flow from the liver. ...Read more

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What exactly is cholestasis?

Bile flow: Usually means disruption (slowing or blockage) of bile flow from the liver. ...Read more

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What is the definition or description of: cholestasis?

What is the definition or description of: cholestasis?

Bile plugged: This means the flow of bile (chole) is held back (stasis). It can be from the liver cells not moving it (often from medications), or from the biliary tree being plugged by stone, tumor, scar, or perhaps something else. ...Read more

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What is cholestasis of pregnancy?

What is cholestasis of pregnancy?

See below please: Cholestasis of pregnancy is a condition in which the normal flow of bile in the gallbladder is affected by the high amounts of pregnancy hormones. Cholestasis is more common in the last trimester of pregnancy. 1-2 pregnancies/1000 are affected by cholestasis. In severe cases, but not all, cholestasis may increase the risks for fetal distress, preterm birth, or stillbirth. Blood tests are key. ...Read more

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Can liver disease cause cholestasis?

Sure, but...: Liver disease comes in many varieties and manifestations: cholestasis (either intrahepatic or extrahepatic) with jaundice; infiltrative (like fatty liver, amyloidosis); fibrotic (trending toward cirrhosis); congestive (blood backs up into the liver); ischemic; shock injury; toxic (either metabolic or drug-related); hepatitis (infectious or otherwise, the liver cells are sick); familial; cancer... ...Read more

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Does cholestasis cause an itchy rectum?

No: Cholestasis should have no particular effect on the rectum itself. ...Read more

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Is cholestasis determined by a basic liver function panel?

Is cholestasis determined by a basic liver function panel?

History/Physical/Lab: Cholestasis is diagnosed by doing a complete medical history, physical examination, and blood tests that evaluate liver function, bile acids, and bilirubin. Additionally, an ultrasound can de done to rule out gall bladder stones causing blockage. 1-2 preg/1000 is affected by cholestasis of pregnancy. It may be related to adverse pregnancy events like preterm labor, or at worse, stillbirth. ...Read more

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My 10 year old son has cholestasis liver. What should be done?

My 10 year old son has cholestasis liver. What should be done?

GI Consult: He should see a pediatric gastroenterologist for a full evaluation of the cause of the cholestasis and for treatment. ...Read more

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Can cholestasis reoccur outside once you have had Cholestasis in Pregnancy?

Can cholestasis reoccur outside once you have had Cholestasis in Pregnancy?

Cholestasis: If someone developed cholestasis in pregnancy then they are at risk to get it again in future pregnancies. If they are having issues while not pregnant then a complete liver and and gallbladder evaluation should be done to look for underlying hepatic and biliary disease ...Read more

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My wife has been diagnosed with cholestasis. How does this affect pregnancy?

In bad way: Upon diagnosis, most providers will prescribe ursodeoxycholic acid. While there is no cure for for it, and no way to guarantee a successful outcome, studies have shown a slightly better fetal and maternal outcome from administration of ursodeoxycholic acid, whereas Cholestyramine appears to only relieve itching. Giving vit k during delivary.

Delivery by 37 completed weeks is considered crucial ...Read more

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I have a kid and miscarried year ago. Want to get pregnant again. How should I prepare to avoid problems like cholestasis.?

High risk pregnany: Most likely cholestasis of pregnancy will reccur in future pregnancy. Establish care with an obstetrician who can manage high risk pregnancy. ...Read more

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How is cholestasis of pregnancy diagnosed?

History/Physical/Lab: Cholestasis is diagnosed by doing a complete medical history, physical examination, and blood tests that evaluate liver function, bile acids, and bilirubin. Additionally, an ultrasound can de done to rule out gall bladder stones causing blockage. 1-2 preg/1000 is affected by cholestasis of pregnancy. It may be related to adverse pregnancy events like preterm labor, or at worse, stillbirth. ...Read more

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What causes cholestasis of pregnancy and what are the symptoms?

Itching & Jaundice: As well as elevated blood levels of bile acids. More common in scandinavia, south america, and multiple gestation pregnancy. An increased sensitivity of some women to the estrogen hormones of pregnancy lead to a reduced ability of their bodies to eliminate bile acids, causing them to accumulate. The condition usually resolves within 2-3 weeks of delivery. ...Read more

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Can intrahepatic cholestasis be a problem if pregnant?

Can intrahepatic cholestasis be a problem if pregnant?

Cholestasis: Cholestasis in pregnancy can be a serious problem. Usually occurs in the third trimester. It's caused by an excess accumulation of bile acids which can be toxic to the fetus. Leading to fetal distress and can even lead to fetal death. One of the most common symptoms is intense itching. Delivery at 36-37 weeks.
If not term, fetal monitoring and monitor liver enzymes and rx for itching. ...Read more

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In pregnancy, can u have cholestasis without the itching?

In pregnancy, can u have cholestasis without the itching?

Yes: Bloodwork will show cholestatic changes. Pruritis (itching) is common but not always present. ...Read more

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Can chronic sleep loss cause cholestasis? Can it cause liver problems?

Can chronic sleep loss cause cholestasis? Can it cause liver problems?

Not really.: Sleep loss is not known to cause liver disease or cholestasis. On the contrary, however, severe cholestasis can result in sleep loss, if the itching from the cholestasis makes it difficult to sleep. ...Read more