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Doctor insights on: Cardiolipin Ig M

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Ana 12 profile it came back positive 1:40 speckled cardiolipin IgM 18.6?

Ana 12 profile it came back positive 1:40 speckled cardiolipin IgM 18.6?

See below: Both of these are low values and should not be used for a specific diagnosis. However, the most important feature is why were these labs drawn. For example what symptoms you were having to have the labs drawn and in that case they may mean slightly more, but just looking at the labs they are low values and dont point to one specific disease. ...Read more

Dr. Gregory Lanza
811 doctors shared insights

Immunoglobulin M (Definition)

There are 5 classes of immune proteins: igg, iga, igm, ige and igd. Igm fights infection. If you produce too little then infections may occur and you have hypogammaglobulinemia. If you have too much you ...Read more


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I have a swollen painful leg. I had a d-dimer 300, globulin 36 & neutrophil 6.44. Recent test anti-cardiolipin IgM was in 82u/ml pt 13.8 is it ok?

I have a swollen painful  leg. I had a d-dimer 300, globulin 36 &  neutrophil 6.44. Recent test anti-cardiolipin IgM was in 82u/ml pt 13.8 is it ok?

Cause of leg pain: Superficial phlebitis can cause this as well as non thrombotic problems such as cellulitis, infections, connective tissue problems etc. See a doc to separate out the confusion. There is always a reason for a painful leg. ...Read more

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I am being tested for Lupus my APTT ratio was 1.16 slightly raised and my cardiolipin IGM was 102ug/l ESR raised but ANA was normal.

I am being tested for Lupus my APTT ratio was 1.16 slightly raised  and my cardiolipin IGM was 102ug/l ESR raised but ANA was normal.

Need more data : This will depend on more information that I have at this point. then ANA could be negative if only a binding essay was used rather than an immunofluorescent assay. You may fulfill criteria for lupus anticoagulant . You will need to have your physician clarify these tests which Lab did them and how accurate they are. ...Read more

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My anti-cardiolipin IgM was in nov 133 / 82 in jan & in feb it came down to 9.38. Should i still be referred & do I need it checked again if so when?

My anti-cardiolipin IgM was in nov 133 / 82 in jan & in feb it came down to 9.38. Should i still be referred & do I need it checked again if so when?

Ask first: Ask first why the test is being run. If there is a suspected blood clotting disorder, yes, you should see a specialist such as a hematologist. If there is an autoimmune disease process, you should see a rheumatologist. If neither of these apply, then question why the test is being run. ...Read more

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I was told that even though My cardiolipin IgM has been high 3 times over a 100 each time since Nov. I should not worry because my IGG is normal.True?

I was told that even though My cardiolipin IgM has been high 3 times over a 100 each time since Nov. I should not worry because my IGG is normal.True?

Depends....: The anti-cardiolopin ab is a screening test; if (+) it does not necessarily mean you have a clinical disease. In addition, there are other tests that are thought to be more sensitive and specific for the diagnosis of antiphospholipid syndrome. Have you had the beta 2 glycoprotein test? Have you ever had 2 documented episodes of blood clots? If no clots and beta 2 (-), then "not to worry". ...Read more

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Ana 12 profile it came back positive 1:40 speckled cardiolipin IgM 18.6?

See below: Both of these are low values and should not be used for a specific diagnosis. However, the most important feature is why were these labs drawn. For example what symptoms you were having to have the labs drawn and in that case they may mean slightly more, but just looking at the labs they are low values and dont point to one specific disease. ...Read more

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My anti-cardiolipin IgM 133u/ml(nov), 82u/ml(feb). Who do I need to see with regards to this? What speciality.

My anti-cardiolipin IgM 133u/ml(nov), 82u/ml(feb). Who do I need to see with regards to this? What speciality.

See details: If this is the only issue, see a hematologist. If it is related to lupus or another connective tissue disorder, see a rheumatologist. ...Read more

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My anti-cardiolipin IgM was checked to rule out mctd. It was in nov 133 / 82 in jan & in feb it came down to 9.38. Does it need to be tested again?

My anti-cardiolipin IgM was checked to rule out mctd. It was in nov 133 / 82 in jan & in feb it came down to 9.38. Does it need to be tested again?

See details: Anticardiolipins never rule in or rule out mctd. They are used to diagnosis specific clotting disorders that can be associated with connective tissue disorders. The levels of anticardiolipins vary up and down and in your case they should be checked once or twice a year, not every month or two. I would urge taking an 81 mg asa daily as protection if your doctor agrees. ...Read more

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My anti-cardiolipin IgM was in nov 133u/ml, 31st jan 82u/ml and on the 4th feb it came down to 9.38 mpl. Can it drop that much in 5 days? Is it error?

My anti-cardiolipin IgM was in nov 133u/ml, 31st jan 82u/ml and on the 4th feb it came down to 9.38 mpl. Can it drop that much in 5 days? Is it error?

Yes: Igm response is an acute response to an infection or inflammation and can drop very quickly if the process has subsided or controlled by medication. ...Read more