Top
30
Doctor insights on: Can I Be Positive For Cml Even Though I Have Had Two Negative Bone Marrow Biopsies

Share
1

1
Bone marrow biopsy/aspiration (chronic cytopenias/fatigue) f/u appt delayed 4 karyotyping. Is that usually to check CML or what else is possible? Thx

Bone marrow biopsy/aspiration (chronic cytopenias/fatigue) f/u appt delayed 4 karyotyping. Is that usually to check CML or what else is possible? Thx

Karyotype important: There are many things that cause low counts. CML isn't one of them - that causes high counts. Getting the genetic testing is very important for making an accurate diagnosis no matter what the diagnosis. I always make my patients wait for that before they come in for their follow-up appointment. I know it's hard to wait, but it's better to get the full and accurate picture all at once. ...Read more

Dr. Jerome Zacks
2 doctors shared insights

Biopsy (Definition)

Biopsy is tissue removed by needle or cutting to remove part of a body part. It is usually a small amount of material that is processed by a pathologist. Most of the time it is stained and looked at through a microscope to arrive at a diagnosis. Special processes are done for some tissues or problems. The purpose is to tell what the problem is (diagnosis). ...Read more


2

2
I have had two bone marrow biospy, both came back negative, but my platelets still drop n, can I have a stroke?How do I cure it, wht is it

I have had two bone marrow biospy, both came back negative, but my platelets still drop n, can I have a stroke?How do I cure it, wht is it

Depends: You may have other reasons that impaired production for low platelets; you could have an overactive spleen (as in cirrhosis or itp), or the platelets may be consumed in circulation. You should be under the care of a hematologist, especially if you have been getting bone marrow biopsies. ...Read more

3

3
My dr says my last two bone marrow biopsys show fibrousis but not enough to diagnosis is there such a thing, is there anything else I can do?

My dr says my last two bone marrow biopsys show fibrousis but not enough to diagnosis is there such a thing, is there anything else I can do?

Yes: Get a second pathologist to look at the marrow. Some folks simply have a bit more connective tissue in the marrow. I'm going to assume the burning question is whether you have myelofibrosis / myeloid metaplasia (you're young for it); histopathology is often inconclusive and perhaps a jak2 gene mutation check is in order. Even if positive, consider the "no treatment" option if offered. ...Read more

4

4
My blood test for jak2 was negative but blood counts are still rising would you recomend bone marrow biopsy?

My blood test for jak2 was negative but blood counts are still rising would you recomend bone marrow biopsy?

Yes: Jak2 testing is supportive of certain myeloproliferative diagnsoses, but the clinical decision to pursue the bm biopsy will be driven by the extent and pace of rise and your symptoms. ...Read more

5

5
Is there any condition that could cause both neutropenia and hypothyroidism? All orderedblood tests and bone marrow biopsy came back normal/negative.

Is there any condition that could cause both neutropenia and hypothyroidism? All orderedblood tests and bone marrow biopsy came back normal/negative.

Unrelated: Hypothyroidism is very common condition, so it is not uncommon to have other conditions that can coexist independent of each other. Neutropenia is often caused by bone marrow damage of some kind or other, although on rare occasions it can be congenital(since birth, cause unknown). The degree of neutropenia matters. So you should give us all the numbers of your CBC...such as WBC count & Neutrrophil ...Read more

6

6
Chronic osteomylitis, bone marrow biopsy normal, jak-2 mutation negative, erythropoitin level normal, s.Ferritin level 5 but hb.17.8.What is its reason ?

Chronic osteomylitis, bone marrow biopsy normal, jak-2 mutation negative, erythropoitin level normal, s.Ferritin level 5 but hb.17.8.What is its reason ?

Many possibilities: Your question is why your hemoglobin is at the top-of-normal (or maybe a tiny bit above) for a person of your age and gender. I'm much, much more concerned about your chronic osteomyelitis. I'd consider a right-to-left cardiac shunt, osler-weber-rendu lung shunt, sleep apnea, high-affinity hemoglobin, an obscure mutation. It's not dangerous in itself & could "just be you.". ...Read more

8

8
Tb skin test negative, quentform TB test negative, bone marrow biopsy results indicative of TB (reacts to ziehl niehlssen), PCR negative. How come?

Tb skin test negative, quentform TB test negative, bone marrow biopsy results indicative of TB (reacts to ziehl niehlssen), PCR negative. How come?

No...actually: The zn stain is a broad stain for acid fast bacilli of which mycobacterium tuberculosis is one of many. The specific tests like quantiferon or the pcr test are against you having tb. The culture is the "gold standard" but you will need to wait for it. It might turn out be a cousin of TB and that too will grow out of culture. Stay on TB meds until they are certain of the AFB positive organism. ...Read more

9

9
Hemoglobin dropped 9.8 to 8.9 in less than 2 mos. Iron, B12 ok, no hep, no hiv. Now being checked for lupus-already have psoriasis. If that's negative then do bone marrow biopsy. Is this really bad?

Hemoglobin dropped 9.8 to 8.9 in less than 2 mos. Iron, B12 ok, no hep, no hiv. Now being checked for lupus-already have psoriasis. If that's negative then do bone marrow biopsy. Is this really bad?

Check for bleeding: Occult blood loss can also cause HGB to drop as can unfortunately, some types of cancers. I don't mean to scare you but have you had an abdominal ultrasound, checked for hidden blood in stool, etc. If not, you should.
Are you also fatigued or have any abnormalities? Ask doctor to be very diligent in your work up. Have you had an serum protein electrophoresis. You should have complete anemia check. ...Read more

11

11
Adult male,bone marrow biopsy show Erythroid hyperplasia RBC borderline on high side,thrombocytopenia fluctuate, Splenomegaly,negative for infections.

Adult male,bone marrow biopsy show Erythroid hyperplasia
RBC borderline on high side,thrombocytopenia fluctuate,
Splenomegaly,negative for infections.

CBC Results: If you can send us the complete blood count (CBC) report which includes Hb, WBC, Platelet counts done from 2 different dates, we can tell you if there is anything serious or how to manage your concerns. WE need to know the number of platelets(Count). RBC numbers are not useful...instead we use hemoglobin as a better test to reflect any problems with RBCs. ...Read more

12

12
Could splenic lymphoma exist even with Negative Bone marrow biopsy & negative PET/CT , but splenomegaly occur? other causes has ruled out.

Could splenic lymphoma exist  even with Negative Bone marrow biopsy & negative PET/CT , but splenomegaly  occur? other causes has ruled out.

Yes/No: Lymphoma can ,on rare occasions, involve spleen alone, sparing all other organs. But PET will show increased uptake(high SUV) and CT would show enlargement of Spleen.
So depending on your symptoms and the degree of enlargment of your spleen, your doctor may, somewhere along the line, consider removal of the spleen(splenectomy). But this step would only be taken if your spleen is causing U any harm ...Read more

14

14
Can you tell me how do bone marrow biopsies work?

See below: Bone marrow biopsy and aspirate are done to diagnose disorders of blood and bone marrow. This site provides a short description of the procedure and indications for the procedure.
http://www.nlm.nih.gov/medlineplus/ency/article/003934.htm. ...Read more

15

15
Is a bone marrow biopsy painful?

Is a bone marrow biopsy painful?

Yes and no: Any biopsy will be painful but in the hands of an experienced doctor and proper sedation (local novocaine) it can be a much more tolerable process. Pain killers such as tylenol (acetaminophen) afterwards for 24-58 hours can be a help too. ...Read more

16

16
What amount is a bone marrow biopsy?

What amount is a bone marrow biopsy?

Bone marrow biopsy?: I am not clear what you are asking--do you want to know how much bone marrow is removed during a bone marrow biopsy?
Generally, 5-15 cc's of marrow is removed during a bone marrow aspiration and then a 2-3 cm small piece of the bone marrow is removed for the biopsy.

If you were trying to get other information please add a more detailed question. ...Read more

17

17
Does a bone marrow biopsy cause pain?

Does a bone marrow biopsy cause pain?

Yes: A bone marrow biopsy unfortunately can be a painful procedure. It is only performed when the benefits outweigh the risks, however. ...Read more

18

18
When do you need a bone marrow biopsy?

Blood disorders: A number of blood disorders like undiagnosed anemia, leukemia, high red cell count, low white cell or platelet count may warrant a bone marrow biopsy. See this site for more info.

http://www.webmd.com/cancer/bone-marrow-aspiration-and-biopsy ...Read more

19

19
Can getting a bone marrow biopsy hurt?

It will hurt: Even with a local anesthetic and some sedation, you can expect a fair amount of pain. Be brave and remember that it's being done to promote your improved health. ...Read more

20

20
What is a bone marrow biopsy done for ?

What is a bone marrow biopsy done for ?

Bone marrow biopsy: Hi, Bone Marrow biopsy is usually performed when a blood cell disorder is suspected, blood cell disorders are: Leukemia, aplastic anemia, multiple mylemoa and etc and some infectious processes. ...Read more

22

22
What makes an a bone marrow biopsy abnormal?

Change in components: A bone marrow biopsy in a normal person will find the pattern of cells most often seen in a healthy person of that age.This would include red cells and their precursers (builders), white cells & precursers, platelet precursers & others. In illness, the pattern changes, and some or all may be abnormal. Tumor cells may take over every space& or few if any normal cells may be seen. ...Read more

23

23
How painful is a bone marrow biopsy typically?

It depends: Some people have a higher pain tolerance than others. Even at the hands of the most skilled physician, a bone marrow biopsy is at least uncomfortable. ...Read more

24

24
Why could someone require a bone-marrow biopsy?

Many Indications: Bone marrow biopsy is most useful in diagnosis and staging of blood cancers (leukemia, lymphoma, multiple myeloma, etc). Also indicated for evaluating unexplained anemia, leukopenia, thrombocytopenia, pancytopenia, or unexplained elevated blood counts. It is also useful for fever of unknown origin, or as a confirmation that bone marrow transplantation is successful. ...Read more

25

25
Where on the body is a bone marrow biopsy done?

Where on the body is a bone marrow biopsy done?

The hip: Biopsies are taken from the upper back portion of the hip. Occasionally, if a suction aspiration is needed, a breastbone puncture can be used. ...Read more

26

26
Are bone marrow biopsies and aspirations risky?

Low risk: There is always risk involved in any procedure. Some have greater risk than others. Generally speaking, bone marrow biopsies are low risk, but your hematologist would be the best person to assess whether the risk outweighs the potential benefit, which is the real question. ...Read more

27

27
Does getting a bone marrow biopsy typically hurt?

Depends: If your receive conscious sedation, you will not have noticeable pain during the procedure. Afterward, you may have pain for a day or so unless there is an untoward complication. I had one and it hurt minimally for 24 hours. I had conscious sedation. ...Read more

28

28
How can you make a bone marrow biopsy less painful?

Sedation: Light sedation can be used, in addition the soft tissues should be numbed to the periosteum, the outer layer of bone. ...Read more

29

29
What can I do about pain in the bone marrow biopsy?

Bone marrow biopsy: If it is done after adequate local anesthesia is used with lidocaine, it should not hurt, maybe little pressure or discomfort at site. After procedure you can take an aleve, advil or tylenol (acetaminophen) to alleviate the pain. ...Read more

30

30
What is the probablity of a clean bone marrow biopsy?

What is the probablity of a clean bone marrow biopsy?

Clarify your questio: In what setting? It depends on what disease, how long you have that, do you have systemic symptoms etc? For more indolent disease - like cll for instance- the chance to see involvement to the bone marrow is pretty high as the disease may have been there for years. For acute leukemia- definitely bone marrow will be abnormal. ...Read more

Bone Marrow (Definition)

Bone marrow is the flexible tissue found in the interior of bones. In humans, red blood cells are produced in the heads of long bones, in a process known as hematopoesis. On average, bone marrow constitutes 4% of the total body mass of humans; in an adult weighing 65 kilograms (140 lb), bone marrow accounts for approximately ...Read more


Bone (Definition)

Bone is a living growing tissue made mostly of collagen (protein that provides soft framework) & the mineral calcium phosphate that adds strength & hardens the framework. Two types of bone are found in the body; cortical (dense compact outer layer) & trabecular (makes up inner layer, ...Read more