Doctor insights on:
Can I Be Positive For Cml Even Though I Have Had Two Negative Bone Marrow Biopsies
Bone marrow biopsy/aspiration (chronic cytopenias/fatigue) f/u appt delayed 4 karyotyping. Is that usually to check CML or what else is possible? Thx
Karyotype important: There are many things that cause low counts. CML isn't one of them - that causes high counts. Getting the genetic testing is very important for making an accurate diagnosis no matter what the diagnosis. I always make my patients wait for that before they come in for their follow-up appointment. I know it's hard to wait, but it's better to get the full and accurate picture all at once. ...Read more
Biopsy is tissue removed by needle or cutting to remove part of a body part. It is usually a small amount of material that is processed by a pathologist. Most of the time it is stained and looked at through a microscope to arrive at a diagnosis. Special processes are done for some tissues or problems. The purpose is to tell what the problem is (diagnosis). ...Read more
I have had two bone marrow biospy, both came back negative, but my platelets still drop n, can I have a stroke?How do I cure it, wht is it
Depends: You may have other reasons that impaired production for low platelets; you could have an overactive spleen (as in cirrhosis or itp), or the platelets may be consumed in circulation. You should be under the care of a hematologist, especially if you have been getting bone marrow biopsies. ...Read more
My dr says my last two bone marrow biopsys show fibrousis but not enough to diagnosis is there such a thing, is there anything else I can do?
Yes: Get a second pathologist to look at the marrow. Some folks simply have a bit more connective tissue in the marrow. I'm going to assume the burning question is whether you have myelofibrosis / myeloid metaplasia (you're young for it); histopathology is often inconclusive and perhaps a jak2 gene mutation check is in order. Even if positive, consider the "no treatment" option if offered. ...Read more
My blood test for jak2 was negative but blood counts are still rising would you recomend bone marrow biopsy?
Yes: Jak2 testing is supportive of certain myeloproliferative diagnsoses, but the clinical decision to pursue the bm biopsy will be driven by the extent and pace of rise and your symptoms. ...Read more
Is there any condition that could cause both neutropenia and hypothyroidism? All orderedblood tests and bone marrow biopsy came back normal/negative.
Unrelated: Hypothyroidism is very common condition, so it is not uncommon to have other conditions that can coexist independent of each other. Neutropenia is often caused by bone marrow damage of some kind or other, although on rare occasions it can be congenital(since birth, cause unknown). The degree of neutropenia matters. So you should give us all the numbers of your CBC...such as WBC count & Neutrrophil ...Read more
Chronic osteomylitis, bone marrow biopsy normal, jak-2 mutation negative, erythropoitin level normal, s.Ferritin level 5 but hb.17.8.What is its reason ?
Many possibilities: Your question is why your hemoglobin is at the top-of-normal (or maybe a tiny bit above) for a person of your age and gender. I'm much, much more concerned about your chronic osteomyelitis. I'd consider a right-to-left cardiac shunt, osler-weber-rendu lung shunt, sleep apnea, high-affinity hemoglobin, an obscure mutation. It's not dangerous in itself & could "just be you.". ...Read more
Tb skin test negative, quentform TB test negative, bone marrow biopsy results indicative of TB (reacts to ziehl niehlssen), PCR negative. How come?
No...actually: The zn stain is a broad stain for acid fast bacilli of which mycobacterium tuberculosis is one of many. The specific tests like quantiferon or the pcr test are against you having tb. The culture is the "gold standard" but you will need to wait for it. It might turn out be a cousin of TB and that too will grow out of culture. Stay on TB meds until they are certain of the AFB positive organism. ...Read more
Hemoglobin dropped 9.8 to 8.9 in less than 2 mos. Iron, B12 ok, no hep, no hiv. Now being checked for lupus-already have psoriasis. If that's negative then do bone marrow biopsy. Is this really bad?
Check for bleeding:
Occult blood loss can also cause HGB to drop as can unfortunately, some types of cancers. I don't mean to scare you but have you had an abdominal ultrasound, checked for hidden blood in stool, etc. If not, you should.
Are you also fatigued or have any abnormalities? Ask doctor to be very diligent in your work up. Have you had an serum protein electrophoresis. You should have complete anemia check. ...Read more
+ ANA test, severe neutropenia with large granular lymphocytes, high monocytes and lymphocytes. Osteoarthritis. Bone marrow biopsy negative. Idea?
Felty syndrome: Get your doc to ask hematologist to do clonality test on blood large granular lymphs by flow cytometry and gene clonality rearrangement ...Read more
Adult male,bone marrow biopsy show Erythroid hyperplasia
RBC borderline on high side,thrombocytopenia fluctuate,
Splenomegaly,negative for infections.
CBC Results: If you can send us the complete blood count (CBC) report which includes Hb, WBC, Platelet counts done from 2 different dates, we can tell you if there is anything serious or how to manage your concerns. WE need to know the number of platelets(Count). RBC numbers are not useful...instead we use hemoglobin as a better test to reflect any problems with RBCs. ...Read more
Could splenic lymphoma exist even with Negative Bone marrow biopsy & negative PET/CT , but splenomegaly occur? other causes has ruled out.
Lymphoma can ,on rare occasions, involve spleen alone, sparing all other organs. But PET will show increased uptake(high SUV) and CT would show enlargement of Spleen.
So depending on your symptoms and the degree of enlargment of your spleen, your doctor may, somewhere along the line, consider removal of the spleen(splenectomy). But this step would only be taken if your spleen is causing U any harm ...Read more
My blood counts are low and the hematologist did a bone marrow aspiration and biopsy even though I have no symptoms. Is this normal?
Bone marrow biopsy?:
I am not clear what you are asking--do you want to know how much bone marrow is removed during a bone marrow biopsy?
Generally, 5-15 cc's of marrow is removed during a bone marrow aspiration and then a 2-3 cm small piece of the bone marrow is removed for the biopsy.
If you were trying to get other information please add a more detailed question. ...Read more
Change in components: A bone marrow biopsy in a normal person will find the pattern of cells most often seen in a healthy person of that age.This would include red cells and their precursers (builders), white cells & precursers, platelet precursers & others. In illness, the pattern changes, and some or all may be abnormal. Tumor cells may take over every space& or few if any normal cells may be seen. ...Read more
Many Indications: Bone marrow biopsy is most useful in diagnosis and staging of blood cancers (leukemia, lymphoma, multiple myeloma, etc). Also indicated for evaluating unexplained anemia, leukopenia, thrombocytopenia, pancytopenia, or unexplained elevated blood counts. It is also useful for fever of unknown origin, or as a confirmation that bone marrow transplantation is successful. ...Read more
Depends: If your receive conscious sedation, you will not have noticeable pain during the procedure. Afterward, you may have pain for a day or so unless there is an untoward complication. I had one and it hurt minimally for 24 hours. I had conscious sedation. ...Read more
Sedation: Light sedation can be used, in addition the soft tissues should be numbed to the periosteum, the outer layer of bone. ...Read more
Clarify your questio: In what setting? It depends on what disease, how long you have that, do you have systemic symptoms etc? For more indolent disease - like cll for instance- the chance to see involvement to the bone marrow is pretty high as the disease may have been there for years. For acute leukemia- definitely bone marrow will be abnormal. ...Read more
Bone marrow is the flexible tissue found in the interior of bones. In humans, red blood cells are produced in the heads of long bones, in a process known as hematopoesis. On average, bone marrow constitutes 4% of the total body mass of humans; in an adult weighing 65 kilograms (140 lb), bone marrow accounts for approximately ...Read more
Bone is a living growing tissue made mostly of collagen (protein that provides soft framework) & the mineral calcium phosphate that adds strength & hardens the framework. Two types of bone are found in the body; cortical (dense compact outer layer) & trabecular (makes up inner layer, ...Read more
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