Doctor insights on:
Acute Inflammatory Pattern On Electrophoresis
Ana positive 1:80 homogeneous pattern & 1:160 centromere pattern...Additional tests needed or just by centromere pattern crest & scleroderma r present?
Mild Psoriasis sufferer, chronic pain right forarm & elbow. Blood tests 80 titre ana, positive anticentromere. Psoriatic arthritis or scleroderma?
Occam's Razor: Usually Systemic Sclerosis and/or limited Scleroderma is not characterized by arthritis like you describe. The typical biomarker the anti Scl-70 (anti-topoisermorase). Symptoms have to be put into context and better described than elbow and forearm pain. This one you should see a rheumatologist about. Dermatology would be useful as well. Best of luck! ...Read more
Can chronic low & giant platelets (80-125) w/o a cause be ITP in adult w. Henoch Schonlein? In/out of HSP remission, Plts same, WBC/RBC vary low-norml
Hsp: hsp doesn't cause any changes in platelet count. I am not sure what do you mean been in and out of remission. The chronic issues with hsp is the blood in the urine, butost of the time it is microscopic. Blood pressure need to be monitored. If you have other issues with platelet count, you probably need to see hematologist to help you sort it out ...Read more
Not sure: The ANA is a nonspecific test and can be seen in numerous disorders and even in normal individuals. The ANA must be evaluated in light of the clinical picture and more specific lab testing. Depending on the CRP test used, a value of 4.8 may be normal or it may be elevated. ...Read moreSee 1 more doctor answer
I know ARD diagnosis depends on the whole clinical picture. Probability-wise, which ARDs are associated with a nuclear coarse speckled ANA pattern?
Depends on other lab: There are a number of rheumatologic diseases that could have that ANA pattern, and it's also possible to have a positive ANA without having a disease. Diagnosis depends on more than just the ANA -- your doctor will probably do other tests, and with all the lab results plus your physical exam, be able to give you a diagnosis. ...Read more
Can inflammation from a severe lupus flare cause an elevated d dimer of 1600? Crp over 200. Esr 50.
See below: Elevated CRP and ESR can be signs of lupus glare up. Lupus can cause hypercoagulable state (meaning you can form clots in the body even if you don't need to). D- dimer is a test for to check for by products of clots in the body. Elevated d dimer needs to be attended by doctor asap. ...Read more
ANA 1:160 homogenous, anti ssDNA 42, normal Rh factor, ESR, anti dsDNA , neg HLA B27. Tests due to severe joint pain- is this indicative of lupus??
Can hypothermia in an elderly pt be a symptom of an acute transformation of overlap myeloproliferative/myelodysplacticty disorder? Pt has hi WBC & CRP
Hypothermia/mds: Elderly often feel cooler than younger individuals. Hypothermia ( how low?) may be a sign of infection /sepsis just like high fever. If one has myelodysplastic syndrome , would check for UTI, a common cause of infection,subtle pneumonia.Also check thyroid, adrenal function. Elevated WBC is a concern for sepsis and transformation. Go to the ER for blood cultures and evaluation. ...Read moreSee 1 more doctor answer
Crp .1 mg/l. Ra/anti-dsdna antibs/ana all negative. Why might hematology report indicate "suggested reactive or inflammatory process"? Also noted subset of reactive lymphocytes, occasionally atypical.
See below : Reactive (atypical) lymphocytes are usually due to viral illness or stressor on the body. It could be due to a medicine reaction or autoimmune disorder as well. Your CRP level of 0.1 is very low which is good. And your ra/anti ds dna are negative. So overall they didn't find anything abnormal and they called it possibly due to reactive process. ...Read moreSee 1 more doctor answer
Biopsy petechiae right arm: spongiotic psoriasiform dermatitis w/purpura. Drug eruption in a pt. W/underlying psoriasis or eruptive psoriasis exacerbated by a drug. What does this mean? Drug allergy?
See your doctor: This is what is called a "descriptive" path report. In these cases we construct a list of conditions that can produce this type of reaction pattern then try to narrow it down if possible. In these cases a good solid history needs to be taken to identify any possible cause (drug or other). I am afraid this can be a challenging process and sometimes we do not find the actual diagnosis. Good luck. ...Read moreSee 1 more doctor answer
ANA 1:320 Homogenous pattern, positive ssDNA, and chromatin antibodies 60 u/ml. Fatigue and joint pain. Is lupus a possibility?
Yes: 1:320 along with positive ssDNA Ab and the symptoms you are having makes Systemic Lupus a strong possibility. I suggest seeing a Rheumatologist so they can also evaluate and potentially initiate treatments. ...Read more
The modified ny criteria for diagnosing anspon includes clinical symptoms. Does acute chronic iritis count as a clinical condition?
Low positive ana, dual pattern speckled, centromere. Positive aca and positive histone ab igg. After c/o skin rash and moderate right hip pain.
Need to be evaluated: A low titer (concentration) ANA test is not particularly helpful to make a diagnosis. Even with a particular pattern (speckled) and anti-centromere antibodies and anti-histone antibodies. Your rash and hip pain are more important as well as inflammatory markers like an ESR and a CBC if they are normal or not. See your doctor and ask for a referral to a rheumatologist if you are concerned. ...Read more
Blood work results: "elevated rheumatoid factor & ccp c/w ra; elevated jo 1 (34h) & anti histone (1.2h) antibodies, mng" what should this mean to me?
Cause of chronic elevated T cell counts with a monoclonal T cell beta gene rearrangement. Bouts of itching reddened skin. Some LGL's noted Normal CBC?
See dermatologist: How do you know the monoclonal T cell status? This suggests mycosis fungoides. I recommend that you see a dermatologist. ...Read more
Feel great - incidental finding ANA 1:160 after acute sinusitis. Then had Anti-DNA, Ant-Smith, SSA/SSB, RNP, SCL-70, Centromere, and Thyroid labs all normal. Does this exclude autoimmune disorder?
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