Doctor insights on:
Mcrc patient aged 65. Drs not willing to
Give any 5-FU drugs due to chest tightness . Tried Xeloda (capecitabine) n irinotecan . What can we do now ?
Define met site.: Regardless of site and extent of mets, primary resection essential. This eliminates any other site of spread. PET/CT will determine met areas after primary removed. If as is usual, mets are to liver, microwave ablation, or chemo embolization or radioactive microspheres given to liver to control disease. Any pulmonary nodes removed thru thorascope. Most protocols contain 5FU (fluorouracil). ...Read more
Follow instructions!: It is safe and effective when used as prescribed. It will irritate your skin, that's part of how it works, so expect it to be red and dry. Remember more is not better, so use it in a thin layer. Limit your sun exposure and use a moisturizer. Don't use it without a doctors recommendation. ...Read more
Yes: Yes it's safe if used as localized injection. There's minimal risk of significant systemic absorption if using small amounts. Important to limit total amount of drug injected so no problem with small scars but if there are lots of big keloids covering the body then need to treat small areas at a time to limit drug exposure. ...Read moreSee 1 more doctor answer
Allergy/side effect: Side effects are known adverse reactions that occur due to the metabolism of the medication or the mechanism of action of the drug that just happens to be undesirable or toxic. Typical allergic reactions (type i hsr) consist of flushing, hives, itching, swelling, respiratory symptoms or GI symptoms. ...Read more
Male, 60, used carac (5-fu) for 4 weeks for many, minor actinic keratoses. A couple of mos. Later, many returned. Should I use it again? How long?
Not a standard treat: Cytoxan (cyclophosphamide) and 5-fu jused to be used as first line chemo for breast cancer, but there are much more effacious drugs available now. I would not use these drugs now as first line treatment fofr anything except in special circumstances. ...Read moreSee 1 more doctor answer
Yes: 5-fu is a type of chemotherapy. It can be given by iv, or in certain cases as a cream that the patient inserts into the vagina with an applicator. I'm not sure why it has been recommended to you, but it has side effects you should understand. Ask your doctor for more information. Good luck! ...Read more
If dr reluctant to give any 5-FU chemo
Due to patient chest issues, tried Xeloda (capecitabine) and irinotecan but failed . Wat other options ?
Good reason: You did not state the type of cancer, the patient's age, or other medical conditions except for "chest issues."If chemotherapy is not working (5FU (fluorouracil) and Xeloda are the same drug in the end and irinotecan is another active drug in colon cancer) then using other drugs may be fruitless. Also if the patient has complications, continuing therapy may cause more harm than good. ...Read more
Yes, absolutely: 5fu (fluorouracil) based chemotherapy is the standard chemotherapy in colon cancer. Combination of 5-FU and oxaliplatin is widely used and a standard regiment of chemotherapy in colorectal cancer. A big randoomized clinical trial in colon cancer ( mosaic study) has demonstrated the overall survival benefit of using combination of 5fu (fluorouracil)/oxaliplatin in stage iii colon cancer and limited case of stage ii disease. ...Read moreSee 1 more doctor answer
If a onco can't give 5 fu chemos to
A pt with colorectal cancer with few mets due to chest issue , what other options are there that r effective. ?
Met CRC: This is too complicated for a 400 character response. Not sure about the "why" can't give 5FU (fluorouracil). Common chemo regimens for metastatic colorectal carcinoma (met CRC) include FOLFOX, FOLFIRI both +/- bevacizumab (Avastin). Other drugs have activity in CRC including regorafenib. Here is NCCN patient information: http://www.nccn.org/patients/guidelines/colon/index.html ...Read more
No: No it will not. No significant interactions known between those two. ...Read more