Doctor insights on:
Mcrc patient aged 65. Drs not willing to Give any 5-FU drugs due to chest tightness. Tried Xeloda (capecitabine) n irinotecan. What can we do now?
Define met site.: Regardless of site and extent of mets, primary resection essential. This eliminates any other site of spread. PET/CT will determine met areas after primary removed. If as is usual, mets are to liver, microwave ablation, or chemo embolization or radioactive microspheres given to liver to control disease. Any pulmonary nodes removed thru thorascope. Most protocols contain 5FU (fluorouracil). ...Read more
Follow instructions!: It is safe and effective when used as prescribed. It will irritate your skin, that's part of how it works, so expect it to be red and dry. Remember more is not better, so use it in a thin layer. Limit your sun exposure and use a moisturizer. Don't use it without a doctors recommendation. ...Read more
Yes: Yes it's safe if used as localized injection. There's minimal risk of significant systemic absorption if using small amounts. Important to limit total amount of drug injected so no problem with small scars but if there are lots of big keloids covering the body then need to treat small areas at a time to limit drug exposure. ...Read more
Inflammed: The purpose of 5Fu (fluorouracil) applied to a wart is to cause your immune system to react or inflame and destroy. The wart will become red, irritated, and potentially oozing. It may also be a little tender if large enough. ...Read more
Allergy/side effect: Side effects are known adverse reactions that occur due to the metabolism of the medication or the mechanism of action of the drug that just happens to be undesirable or toxic. Typical allergic reactions (type I hsr) consist of flushing, hives, itching, swelling, respiratory symptoms or GI symptoms. ...Read more
YES: Yes, sounds right. Xeloda (capecitabine) is a 5-FU oral prodrug given with Oxaliplatin IV usually for colorectal cancer. This regimen is known as XELOX. ...Read more
Male, 60, used carac (5-fu) for 4 weeks for many, minor actinic keratoses. A couple of mos. Later, many returned. Should I use it again? How long?
See your doctor: See the doctor that prescribed the Carac and let them see if they appear as actinic keratoses, or something else. It can be used more than once, if needed. ...Read more
Yes: 5-fu is a type of chemotherapy. It can be given by iv, or in certain cases as a cream that the patient inserts into the vagina with an applicator. I'm not sure why it has been recommended to you, but it has side effects you should understand. Ask your doctor for more information. Good luck! ...Read more
If dr reluctant to give any 5-FU chemo Due to patient chest issues, tried Xeloda (capecitabine) and irinotecan but failed. Wat other options?
Good reason: You did not state the type of cancer, the patient's age, or other medical conditions except for "chest issues."If chemotherapy is not working (5FU (fluorouracil) and Xeloda are the same drug in the end and irinotecan is another active drug in colon cancer) then using other drugs may be fruitless. Also if the patient has complications, continuing therapy may cause more harm than good. ...Read more
Yes, absolutely: 5fu (fluorouracil) based chemotherapy is the standard chemotherapy in colon cancer. Combination of 5-FU and oxaliplatin is widely used and a standard regiment of chemotherapy in colorectal cancer. A big randoomized clinical trial in colon cancer (mosaic study) has demonstrated the overall survival benefit of using combination of 5fu (fluorouracil)/oxaliplatin in stage iii colon cancer and limited case of stage ii disease. ...Read more
5 fluorouracil: 5fu (fluorouracil) is part of many regimens for many type of cancers- like- GI cancer (esophagus, stomach, colon, rectal, anal etc), head and neck, breast, etc. 5-FU is one of the oldest chemotherapy- has been used for more than 50 years to treat cancer. ...Read more
Vaginal dysplasia: 5-fu is usually reserved for severe vaginal dysplasia & is a treatment option. It's not usually used on the cervix & rarely used anymore for mild disease. Make sure you ask your doc why it's recommended for you. Good luck. ...Read more
Yes: 5-fu + Cisplatin is a regimen for metastatic cancers ei: anal, biliary, head & neck, esophageal and gastric to name a few. Although they may be other preferred regimens for these cancers. The oncologist will decide what option would be best. ...Read more
If a onco can't give 5 fu chemos to A pt with colorectal cancer with few mets due to chest issue, what other options are there that r effective.?
Met CRC: This is too complicated for a 400 character response. Not sure about the "why" can't give 5FU (fluorouracil). Common chemo regimens for metastatic colorectal carcinoma (met CRC) include FOLFOX, FOLFIRI both +/- bevacizumab (Avastin). Other drugs have activity in CRC including regorafenib. Here is NCCN patient information: http://www. Nccn. Org/patients/guidelines/colon/index. Html ...Read more
No: No it will not. No significant interactions known between those two. ...Read more
Common treatment: Recurrent keloid scars can be very challenging to treat. Kenalog (triamcinolone) - a steroid- is very commonly used to help prevent the regrowth of keloids. In some cases 5-fu may be used as well to treat bad keloids. The doses are usually very small and safe. You should discuss your concerns with your surgeon. ...Read more
Yes it can be done: These 3 drugs have been use din combination in the past. Not a great combination in general but it can be done. ...Read more
Top onco says 5-FU for 6 months is best protocol for 87 yr man. W/adenocarcinoma of stomach. Had partial gastrectomy & 9\26 positive lymph nodes. True?
Dubious: Unaware data supporting benefit of sole 5fu (fluorouracil) adjuvant therapy of n3 gastric adenocarcinoma after complete resection (negative margins). If a "young" 87 yo deemed able to tolerate aggressive treatment-then give standard rx (see nccn guidelines-but note 87 yo were not studied). While your onco well intentioned, consider second opinion and quality of life. Survival possible without chemo. ...Read more
In general, is Gemzar (gemcitabine) as chemo for pancreatic cancer more potent with many more side effects that most other agents, like 5-FU?
One of the best drug: Gemzar (gemcitabine) was the first approved drug and was superior to 5-FU for treating this cancer. So it continues to be the key drugs in the newer combinatiions being developed (or recently developed such as NAb-Paclitaxel+Gemzar (gemcitabine)). It does not have any serious toxicities just lowers the blood counts which is mostly inconsequential. ...Read more
Can 5-fu be used on hypertrophic scar on nose? It is an old scar from cystic pimple. Is there non-steroid alternative to 5-fu? Thanks.
Improve not remove: Many options exist for cosmetic improvement and include anti-inflammatories, peels, exfoliation, lasers, resurfacing, bleaching, excision, grafting, fillers, and much more, scars vary in their severity and so do the treatments. See a plastic surgeon, dermatologist or ENT for options. ...Read more
Fluorouracil, also called 5-fu for vaginal treatment. I was diag w/highrisk hpv, cin1 and was told to use 1app full 1x a wk what are the side effects?
Irritation....: ...In your vagina is the main side effect. Do not use if you could be pregnant. ...Read more
Pt is 65. We are stuck as they reluctant to give chemo due to 5 fu chest tightness. They are also refusing to ablate or operate. The liver met is single and small and lung nodule is 0.5 cm. There is a aortocaval node too. Should we get a 2 nd opinion?
Yes...: Always get a 2nd opinion in a case like this ...Read more
Top cancer dr wants to start 87 yr dad on 5-FU for 6 months b/c he says there are no side effects other than possible mouth sores & peeling skin. True?
Benefits VS risks: If your dad is very healthy 87 why not, should not deprive cancer treatments due age alone. If your dad is mentally incompetent, fragile, then family (health proxy) should decide with the advise from medical team. End stage of journey in this world, it is quality of life, not quantity is important, will make your decisions very simple. ...Read more