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Doctor insights on: 2 Step Tb Test

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Dr. Scott Lindquist
613 doctors shared insights

Mycobacterium Tuberculosis Infection (Definition)

Mycobacterium tuberculosis is an infectious organism that spreads by droplets coughed out by an infected person. Infection is established initially in lungs, but can spread within lungs & to other body parts, or can become latent, with reactivation occurring years to decades later. With effective treatment, it can be completely eliminated although drug resistant ...Read more


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What to do if I had 2 positive home pregnancy tests, 2 negative urine tests @ clinic, & 1 negative blood test @ lab?

What to do if I had 2 positive home pregnancy tests, 2 negative urine tests @ clinic, & 1 negative blood test @ lab?

Not pregnant: If blood HCG is negative, you are not currently pregnant. Call GYN if you go more than 8 weeks from your last period without getting another period.For more info: www.askyourgynecologist.org ...Read more

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2 false pos ELISA HIV tests, all 1 1/2 years post exposure. Neg western blot, ifa, naat and 2 neg oraquick home tests. What is my HIV status? Help!

2 false pos ELISA HIV tests, all 1 1/2 years post exposure. Neg western blot, ifa, naat and 2 neg oraquick home tests. What is my HIV status? Help!

Likely negative: There is typically a "window" of 3-6 months after exposure where you could be HIV positive but test negative. Since you didn't get your testing until well after that, i'd say the confirmatory tests (western blot, ifa) are what you should go by. The elisa is very sensitive and can have false positives- that's why we rely on the confirmatory tests. I would consider your status to be negative. ...Read more

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Tuberculosis vaccinated, TB test positive...Will my ANA be positive because of TB test positive due to vaccine?

Tuberculosis vaccinated, TB test positive...Will my ANA be positive because of TB test positive due to vaccine?

No: There is no cross reaction between them. By the way, up to 5% of normal individuals may test positive to ANA test, usually at low titer. ...Read more

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False positive hep c antibody tests? I have had 2 positive tests 1.04, 1.15 and one negative test. Also 2 negative PCR tests, 18 wks after needle stic

False positive hep c antibody tests? I have had 2 positive tests 1.04, 1.15 and one negative test. Also 2 negative PCR tests, 18 wks after needle stic

Hep C unlikely: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, give than Hep C pcr test was negative at 18 weeks after exposure, it is unlikely that you have Hep C infection. ...Read more

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What is happening when 2 tests show a positive negative in hepatitis c?

What is happening when 2 tests show a positive negative in hepatitis c?

Antibody and RNA?: Most likely, what you are asking is why an hcv antibody test can be positive, while the follow up hcv RNA (viral load) test is negative. About 25% of people who are exposed to hcv will spontaneously clear their infection. That means the antibody is positive (the immune system remembers the exposure) but there is no active viral infection. These people can still get infected if re-exposed. ...Read more

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Tb skin test negative, quentform TB test negative, bone marrow biopsy results indicative of TB (reacts to ziehl niehlssen), PCR negative. How come?

Tb skin test negative, quentform TB test negative, bone marrow biopsy results indicative of TB (reacts to ziehl niehlssen), PCR negative. How come?

No...actually: The zn stain is a broad stain for acid fast bacilli of which mycobacterium tuberculosis is one of many. The specific tests like quantiferon or the pcr test are against you having tb. The culture is the "gold standard" but you will need to wait for it. It might turn out be a cousin of TB and that too will grow out of culture. Stay on TB meds until they are certain of the AFB positive organism. ...Read more

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2 TB skin tests. Bumps measured 15cm. RN stated I possibly have LTBI & ordered QuantiFERON Gold in-tube test. Could anything cause a false positive?

2 TB skin tests. Bumps measured 15cm. RN stated I possibly have LTBI & ordered QuantiFERON Gold in-tube test. Could anything cause a false positive?

Not at 15cm, but...: The bump is more likely 15mm, because 15cm is 6 inches and HUGE. A 15mm bump on a screening test is big but may still be a false positive (a screening test means the patient has NO symptoms of tuberculosis). If a patient has contacted somebody with TB, or has current symptoms, she likely has a true positive unless her bump is due to past BCG vaccine. The Quantiferon-TB blood test is very accurate ...Read more

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How can u get 1 positive chlamydia test swab only- and get negative tests right after? Had 2 confirmatory tests after- w/ swab/urine-negative

How can u get 1 positive chlamydia test swab only- and get negative tests right after? Had 2 confirmatory tests after- w/ swab/urine-negative

Trust positive test: If u had cervical swab positive for chlamydia, I would trust that result, and not have done confirmatory tests which may have not been collected properly. The risk of untreated Chlamydia far outweighs the risk of side-effects from treatment. Make sure your partner(s) get tested and treated, and do not resume sex with them until at least 7 days after u both have been treated. Use condoms. ...Read more

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CMIA 4th gen antibody screening test (not antigen) for hiv 1 & 2 @50 days is 0.15 non reactive.Is antibody screening without antigen accurate @7thweek?

CMIA 4th gen antibody screening test (not antigen) for hiv 1 & 2 @50 days is 0.15 non reactive.Is antibody screening without antigen accurate @7thweek?

Conclusive at 6+ wk: Official advice by many agencies is that stand-alone HIV antibody tests are not conclusive until 3 months. However, with the modern tests in current use, including the test you had, the results actually are conclusive any time 6 or more weeks after exposure. Feel free to have another test at 3 months if another negative result will help you get beyond your fears. But i really isn't necessary. ...Read more

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Is a 2 month(62 days) HIV antibodies test accurate? I tested negative. Someone?

Is a 2 month(62 days)  HIV antibodies test accurate? I tested negative.  Someone?

Get HIV nucleic acid: Test. The antibody tests are generally accurate, but there is a wide variation in the time taken by different individuals to make antibodies. Testing for HIV nucleic acid, if negative, would be more reassuring. ...Read more

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Elisa hbsag was negative in may 2013 befr my dnc.Now another lab test shows hbsag positive during blood test fr fertility treatmnt.can tis be true?

Elisa hbsag was negative in may 2013 befr my dnc.Now another lab test shows hbsag positive during blood test fr fertility treatmnt.can tis be true?

Yes, but...: If a person converts from HepBsAg negative to HepBsAg positive, her primary care doctor can evaluate her and order a larger panel of Hepatitis B tests to see what is going on. If HepBsAg is confirmed to be positive, the patient is contagious with HepB viruses (which are spread through blood and bodily fluids contact). That means all household contacts should have their HepB immunity confirmed. ...Read more

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Will tremponal tests (eia, ClIA ) become positive before non tremponal tests (rpr,vdrl)?

Will tremponal  tests (eia, ClIA ) become positive before non tremponal tests (rpr,vdrl)?

It can happen: Revised reply: disregard earlier one if you saw it. At first I misunderstood the question. The newer TP specific IgG/IgM tests (EIA etc) and RPR/VDRL have similar seroconversion times, typically 4-6 weeks. The IgG tests often are positive first, but exact frequency of this isn't yet known -- more study needed. Apologies again if any confusion from earlier reply. ...Read more

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Lab comment under negetive HIV result:to assess seroconversio plz repeat after 2 weeks.why?

Lab comment under negetive HIV result:to assess seroconversio  plz repeat after 2 weeks.why?

Only if new exposure: This depends on the time since the last possible exposure to HIV. The statement reminds your doctor that if you have been exposed recently, another test may be necessary. Depending on the exact test that was done, it takes 4 to 8 weeks for antibody tests to turn positive, rarely up to 3 months for some, especially the oral fluids test or older (first or second generation) tests. ...Read more

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5days late now 2 expensive test came positive 2 cheap test was negative. Doctor urine test negative. Am i pregnant? Please need help.

5days late now 2 expensive test came positive 2 cheap test was negative. Doctor urine test negative. Am i pregnant? Please need help.

Blood test : If you are getting different results from different urine tests then the only way to confirm which is correct is to do a blood bhcg hormone test. Without that we would be simply guessing which test to believe. ...Read more

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What is a control:positive in a western blot test? All 10 bands negative & interpretation says neg for hiv 1&2. Lab said it's a test setting. Help!

What is a control:positive in a western blot test? All 10 bands negative & interpretation says neg for hiv 1&2. Lab said it's a test setting. Help!

Quality control: In a lab test, the control is the test done by the lab at the same time as when the lab tests the patient's sample. If the control test worked properly, meaning it was positive when a positive control result was expected, or it was negative when a negative control result was expected, then the lab knows that the testing done on the patient's sample is reliable and accurate. ...Read more

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Hep-c test =positive and anti HCV antibody test result = negative what it mean ? And is it require to take HBV vaccination?

Hep-c test =positive and anti HCV antibody test result = negative what it mean ? And is it require to take HBV vaccination?

Unrelated issue: It sounds like the screening test for hcv was positive, but not confirmed. This would not speak to the need or lack thereof for hepatitis b vaccination. ...Read more

Dr. Klaus d Lessnau
1,212 doctors shared insights

Tuberculosis (Definition)

A potentially serious infectious bacterial disease that ...Read more