Doctor insights on:
19911 A>G Mutation Analysis
Protein, ur(mg/24 h) - (0-150 mg/24 hr) 324 h protein, total urine - (0-84 mg/gcr) 161 h creatinine clearance - (85.0 - 125.0) 140.6 h creatinine, ur(mg/h) - (41.7 - 83.3) 84.2 h.. My kidneys okay?
May not be okay...: Based on one set of test, a definitive conclusion can not be drawn. In fact, a good history, physical exam, serial tests in conjunction with other related tests are required to deduce a conclusion and give a reasonable advice. But, for sure, you need a close follow-up by a related professional such as pcp or nephrologist. Best. ...Read moreSee 1 more doctor answer
In genetics, a mutation is a change in the nucleotide sequence of the genome of an organism, virus, or extrachromosomal genetic element. Mutations result from unrepaired damage to dna or to RNA genomes (typically caused by radiation or chemical mutagens), from errors in the process of replication, or from the insertion or deletion of segments of dna ...Read more
Semen analysis report: count 30 million volume 7, pH 7.5, motility 30%, normal morphology 80%, viscosity good. Total motile sperm 63 mil. Good?
Semen: Your count of 30 million is good although your motility is low. Volume is over the top. ...Read more
CML 10/12. Gleevec .5 log at 6 mths. Sprycel (dasatinib) .5 log at 6 mths. Stem cell transplant 4/14. 7/14 Blast crisis - 65% blast BM + Aspergillus F lung Help?
Difficult case: it is a complicated case obviously. first and foremost the infection has to be treated. i would suggest you to follow up with ID and oncologist very closely. importantly is to check if there is certain mutation like T315i mutation as this mutation is resistant to gleevec, sprycel, tasigna (nilotinib) - and should be treated with ponatinib or aurora kinase inhibitor etc. discuss with oncologist. God bless ...Read more
Blood: creatinine 1.80; GFR 41. Follow-up labs 48 hrs later: creatinine 1.50; GFR 53. Imm% - 1.8; imm count - .16. Wbc normal. No symptoms. 46-w-male?
Kidney down briefly?: Both are a bit high for a man in his mid-40s especially if your bodybuilding days are over. Might you have been recovering from a subclinical bout of Ibuprofen nephropathy? It's very common and causes partial renal shutdown. Drink plenty of water if you use nsaids nad consider a follow at your next regular appointment. ...Read more
Why PCR isnt good test for HIV diagnosis? Is it high Cost or low Accuracy?
PCR RNA is better or DNA @ 6 mnth?
Neg 3 DNA & 1 RNA PCR are 100% accurate?
My dad 70 yrs has macrocytic anemia. Hemoglobin 9.5, hematocrit 28. Hematologist gave maltofer pill a day. In a month hemoglobin 10 hematocrit 30?
What is the question: Please rephrase your question to get a better answer. Please discuss in detail with his hematologist. The fact that hematologist gave the iron- means that your hematologist thinks there is a component of iron deficiency. So, continue iron and f/u with your md. However, it does not fit exactly with macrocytosis. Other work up still needs to be done to see explanation for macrocytosis. ...Read moreSee 1 more doctor answer
14/male results/ catecholamine norm?
Norepinephrine, supine 136.0 pg/ml
* epinephrine, <10 pg/ml
*dopamine, <10 pg/ml
norepinephrine, stand 457.0 pg/ml
epinephrine, 14.0 pg/ml
dopamine, 16.0 pg/m
I had the following test results- what do they mean? Rfactor -7, ANA choice screen - positive, rnp antibody- 2.0, DNA da antibody 5
My father in law had his prostate removed a little over 1yr. Blood test: hemoglobin 9.8 iron 27 hct 31 MCV 71 RBC 4.4 mchc 31 MCH 22 RDW 19.6. Help?
Are the WBC results 15.6, 14.4, 11.4, 13.5, 12.7, 16.7, 14.4 13.3, 12.4, 15.3, 13.9, 14.4 & 17.8 slightly, moderately or highly elevated in general?
Blood tests: There are a few diseases that leap out from blood tests. Most of the time, however, blood tests don't tell the doctor much on their own. These results fall into the second group. Good health to you. It is reassuring that the results do not consistently keep rising. ...Read more
Wbc 13.2 RBC 4.73 hemoglobin 10.2 hematocrit 33.8 mvc 72 MCH 21.6 mchc 30.2 RDW 16.2 platelets 816, 000.Thoughts?Should i be worried with the platelets
Probably reactive: You are anemic and the numbers are suspicious for iron deficiency. If you are a healthy 34 year-old who menstruates regularly, you could easily be low in iron. The plaelet count is very high, but is likely reacting to the low iron and should come down if it is replaced. The elevated white cells (WBC) is not as easy to understand. Inflamation, infection, other? Could use more info. Good luck. ...Read more
Ivf hCG 1st 12 days post 5 days transfer 1st 61, 48 hlater 95, 48hl 75, 48hl up 108, 48 hl 42, 96 hl up 90, 1 week l. 550. 1wl 1016 ectopic?
Too early: It's too early to tell at this point. ...Read more
Chloride 94.9 L, Anion Gap 16.1 H, AST 58 H, Immature Granulocytes ABS 0.01 H,Ketones urine SMALL NEG. A, specific gravity urine <1.005 L. ?
Blood work showed lymph's @ 16.9% with reference range of 20.0 - 50.0. Platelet count was 65 with reference range150-400 thou/u. What could this mean?
Need more info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, if your absolute lymphocyte count is low then along with the low platelet count it suggests a problem with production in the bone marrow. It would be prudent to consult a hematologist. ...Read more
Normocyt, WNL RDW, anemia-hgb 13, rbc 4.3. PO Fe for 1 yr w/ no improvement. Fe 58, ferritin 15, TIBC 347. Asymptomatic. Thoughts on IV iron?
Too aggressive: With the numbers you're presenting I'm not sure who put the idea of doing IV iron into your thought process. Hb-13 for age 74 isn't far off of expected norms for age. If you want to do SOMETHING check thyroids, serum zinc, serum magnesium, & serum Vitamin D. Eat more spinach, beans, dried fruit, seafood, & poultry. Questions? www.healthtap.com/drsaghafi Use Key Code: PDXFNR to make appointment. ...Read more
Bloodpresure was 190/109 @ 6am 8:30am 153/93 @10am 167/ 128 what could be
causing this swing in presure? Normal BP 120-138/ 60-84
Today my doctor prescribe a infertility medicns i.E tinidazole , l_methylfolate, chymoral forte, third generation cephalosporin.Is that good medicn?
30 y/o F
free testosterone 7.9 (%1.6)
Sex hormone-binding globulin 42
Free t4 1.01
Free t3 (liothyronine) 2.9
vitamin D 32
Information needed: please provide some context for your question, as I do not understand what you are asking with these numbers alone or what your concern is. ...Read more
According to atp-iii guidelines hdl-c >59 mg/dl is considered a negative risk factor for chd. What does this mean?
43 y/o, male. RBC count was 4.45 million / mm3 in July and Dec. Other CBC tests are normal. Any clinical significance or concern ?
Normal can vary. : Your number of red cells can fluctuate based on various things including fluid intake. If hemoglobin and cell volumes are still normal there is little worry in these slight deviation from normal. ...Read more
Can you definitively rule out lynch syndrome in patients tested neg for msi/ihc without germline mutation analysis? If not, what additional indications are required for md to order germline analysis?
See below: Lynch sydrome is caused by a germline mutation in a gene leading to msi. Combined testing for msi, and using ihc to look for genetic abnormalities leading to msi are the best tests to determine if you have lynch syndrome. Further genetic testing could be done in people who test positive for msi or ihc. Please see: http://www.Mayoclinic.Com/health/lynch-syndrome/ds00669/dsection=tests-and-diagnosis. ...Read moreSee 1 more doctor answer
If a mutation is new & SIFT analysis predicts deleterious, but you only fit some of the criteria for the diagnosis, do you give the diagnose?
Thyroseq v2 was mutations NOT detected but analysis limited due to low amount of thyroid epithelial cells.So this test was useless?
Totally: B"sd absolutely right - genetic studies should only be done on an appropriate tissue specimen. To my knowlege, specimens are screened for adequacy before such testing. If the biopsy was indicated in the first place then it must be repeated - usually after an appropriate interval to allow the "needled" tissue to heal. ...Read more
Can I be diagnosed with Gilbert's syndrome only based on my blood bilirubin levels although my 1& 2 UGT1A1 gene analysis came normal (no mutations)?
PossibleOtherVariant: Although your 1&2 UGT1A1 Gene analysis is normal.This variant account for 50%of alleles in many populations.However several allallelic polymorphic variants of this region occur.The most common of which results from adding another dinucleotide repeat TA to the promotor region resulting in A(TA7)AA .So there are other variants in people from south east asia,East Asians and pacific islanders ...Read more
Hello,i am twice i have abortion and i made Androgen analysis and this is the result( Tag Androgen in exon 1 of androgen receptor gens typ of mutation 23 high risk of abortion) Doctor what do you think about this analysis and what is the cure for it
Not Standard Care: Doctors in the US generally do not send genetic analyses as detailed as yours b/c we do not fully know what to do with results like that which may not bear significance on future pregnancies. We usually examine chromosomes but not genes. Is that genetic analysis from YOU or from the remnants of the pregnancy? For more information, see a genetic counselor. ...Read more
Mutation is a change: In genetics, a mutation is a change in the nucleotide sequence of the genome of an organism, virus, or extrachromosomal genetic element. Mutations result from unrepaired damage to dna or to RNA genomes (typically caused by radiation or chemical mutagens), from errors in the process of replication, or from the insertion or deletion of segments of dna by mobile genetic elements. ...Read more
Good and bad effects: Mutations are genetic changes that can eliminate a problem, cause a problem or introduce a new solution to the environment. Since most mutations create problems, they have achieved a bad name. But most evolutionary change comes about from the effects of new mutations. ...Read more
Clarify: Blood does not mutate. Genes mutate. A genetic mutation (germline as inherited, somatic as in a neoplastic growth) might affect the blood. Someone who knows their subject won't use the term "blood mutation." perhaps there is a misunderstanding. ...Read more
New protein: Most mutations are problematic and create difficulty or are eliminate with normal bodily defenses. Rarely a mutation makes a new protein which has a useful function manifested as a change in the body or metabolism which confers and advantage and will therefore likely survive to the next generation. ...Read more
Yes, a gene mutation: Hemophilia "a" is a hereditary bleeding disorder where there is a deficiency in clotting factor viii (factor viii is needed for blood clotting). It is inherited on the x-chromosome (sex-linked). Men only have 1 "x", so if their "x" is mutated, they will have the disease. Women have 2 "x's", so they can have 1 mutated "x" and 1 normal "x", and be a carrier of the disease, with mild or no symptoms. ...Read moreSee 1 more doctor answer
X-linked mutation: Barth syndrome, also known as 3-methylglutaconic aciduria type II (MGCA2), is caused by mutation in the tafazzin gene (TAZ) on chromosome Xq28. Each boy born to a carrier mother has a 50% chance of having it. Each daughter of a carrier mother has a 50% chance of being a carrier. All daughters of men with Barth Syndrome are carriers. https://www.barthsyndrome.org/home has information & resources. ...Read more
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