Doctor insights on:
17 Hydroxyprogesterone Baseline
CAH: This is most commonly do to non-classical congenital adrenal hyperplasia or ncah. If 17-hydroxyprogesterone levels are just slightly above normal, the correlation may not be very clear cut. If 17 -hydroxyprogesterone level is elevated and pcos symptoms are present, ncah should be considered. ...Read more
My doc has prescribed me 17 hydroxyprogesterone, androsstenedione, 25 hydroxy d tests. Bt i think i hv cushings. Wil these indicate cortisol levels too?
No: Elevated 17 hydroxyprogesterone and androstenedione are indicative of certain forms of late onset congenital adrenal hyperplasia (cah) a condition that usually leads to mild cortisol deficiency. Cushing syndrome is cortisol excess. The two could share some signs but are quite different. Cushing syndrome is screened for with 24h urine free cortisol and overnight Dexamethasone suppression test. ...Read more
I'm having a 17-hydroxyprogesterone (17-OHP) lab to test for non-classical form of CAH. When is the best time during my menstrual cycle to have this?
A 17-OHP test can be: done any time in the menstrual cycle. You may need to fast for 8 hrs. before the test. Birth control pills, steroids & other meds alter results; tell your MD all prescription, OTC, herbal & illicit drugs you take. If your 17-OHP level is equivocal, your doctor may order an ACTH test & molecular genetic studies for CYP21 gene mutations on Chr. 6p21.33 for definitive diagnosis. ...Read more
No 21OH-ase defect: 17 hydroxyprogesterone screens for a congenital condition, congenital adrenal hypertrophy (cah) which can lead to abnormalities of normal cortisol production and excessive adrenal male hormone production. These can present at birth, in childhood, adolescence, or adulthood depending on the nature and severity of the defect. The sensitivity of the baseline test can be increased with acth stimulation. ...Read more
Not really: the hydroxyprogesterone family all tend to be anti-androgenic. Hope this was helpful. Best of luck. Dr. R ...Read more
Hydroxyprogesterone hexanoate is made from 16-dehydropregnenolone acetate,does it have androgenic activity?
I am being tested for Cushings Disease. High DHEA-S, Hydroxyprogesterone and Cortisol levels, anything else I should be concerned about?
Concerned: Yes you should be concerned but relax - your doctor will carefully go through the conditions you listed and probably see if you have additional issues. If you can, try and let the doctor know when you began to realize that something was a bit wrong. Please keep me posted. ...Read more
What if the DHEA-S is high and you are not taking supplements? Mine has been flagged high twice in 7 months, so has my hydroxyprogesterone + cortisol
Hydroxyprogesterone hexanoate is androgen precursor with elimination half-life 7.8 d,for an injection 5ml of 250 mg/mL what is such androgenic effect?
A Hairy Proposition: In women, excess amounts of androgens can cause such "virilizing" effects as acne, hirsutism (excess hair growth in "inappropriate" places, like the chin or upper lip) and thinning hair. Long-time use is associated with serious health consequences, such as insulin resistance and diabetes, high cholesterol, high blood pressure and heart disease. It all sounds like lots of fun, doesn't it? ...Read more
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