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Doctor insights on: 0 Negative Inflammatory Arthritis

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Dr. Thomas Namey
2,426 doctors shared insights

Arthritis (Definition)

A condition where there is progressive degeneration of one or more joints. Symptoms may include joint pain, swelling, decreased motion, and stiffness. The two most common types of arthritis are osteoarthritis, which is associated first with articular cartilage breakdown with a component of inflammation, and rheumatoid arthritis, which is a systemic autoimmune disorder that affects joint linings first and secondarily ...Read more


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Mild Psoriasis sufferer, chronic pain right forarm & elbow. Blood tests 80 titre ana, positive anticentromere. Psoriatic arthritis or scleroderma?

Mild Psoriasis sufferer, chronic pain right forarm & elbow. Blood tests 80 titre ana, positive anticentromere. Psoriatic arthritis or scleroderma?

Occam's Razor: Usually Systemic Sclerosis and/or limited Scleroderma is not characterized by arthritis like you describe. The typical biomarker the anti Scl-70 (anti-topoisermorase). Symptoms have to be put into context and better described than elbow and forearm pain. This one you should see a rheumatologist about. Dermatology would be useful as well. Best of luck! ...Read more

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ANA 1:160 homogenous, anti ssDNA 42, normal Rh factor, ESR, anti dsDNA , neg HLA B27. Tests due to severe joint pain- is this indicative of lupus??

ANA 1:160 homogenous, anti ssDNA 42, normal Rh factor, ESR, anti dsDNA , neg HLA B27. Tests due to severe joint pain- is this indicative of lupus??

Might be.: These labs do not rule lupus out nor do they rule it in. I think your doc should keep looking and monitor your progress over time. Depending upon joints could represent parvovirus although that is just a wild guess. Your clinical picture and progress is most important. ...Read more

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Can anything other than myositis cause elevated jo 1 antibody? Possible false positive? Could I have been wrongly diagnosed w/ rheumatoid arthritis?

Can anything other than myositis cause elevated jo 1 antibody? Possible false positive? Could I have been wrongly diagnosed w/ rheumatoid arthritis?

Usually not RA.: Myositis can be associated with several types of autoantibodies: anti-jo1 antibodies are a type of anti-nuclear antibody. Anti-srp antibodies are mainly associated with, but are not specific for, polymyositis. The ccp antibody is most specific for ra. Keep in mind that certain meds for RA also work in myositis, such as Methotrexate and steroids. ...Read more

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What could a positive ANA of 1:640 speckled indicate if lupus and rheumatoid arthritis tests are negative?

What could a positive ANA of 1:640 speckled indicate if lupus and rheumatoid arthritis tests are negative?

Need more testing: ANA is a screening test. A positive result only indicates more testing might be needed. The speckled portion of the result is not very helpful on its own. About 5% of humans (1 in 20) have a positive ANA for no reason. ...Read more

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Ana positive, 1:320 centromere pattern. Some joint pain, some swelling, fatigue. Could I have lupus or scleroderma?

Ana positive, 1:320 centromere pattern.  Some joint pain, some swelling, fatigue.  Could I have lupus or scleroderma?

See below: Lab results need to be interpreted in the clinical context and the doctor who ordered the test is usually in the best position to do that. The information you provided suggests scleroderma/crest. See this site for more info and discuss with your doctor. http://www.mayoclinic.com/health/scleroderma/ds00362. ...Read more

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Had many negetive GI test. Fat malabsorption/pots/no reynards syndrome no skin problems back inflammation. ? Sclerederma, ibs, ankylosing spondylitis?

Had many negetive GI test. Fat malabsorption/pots/no reynards syndrome no skin problems back inflammation. ? Sclerederma, ibs, ankylosing spondylitis?

Spondyloarthropathy: Sero negative spondyloarthropathy is a possibity. Shares many features symptomatically with as, but without hla-b27 positive. If your back pain is associated with sacroiliac pain (buttock pain to back of thigh, maybe groin, but not past knee) then it would be suspect. This is one if those cases where specialist eval would help. Rheumatology is best suited for diagnosis and treatment. ...Read more

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I have joint pain and sometimes feel fever,twitching. Ana 1:40 but Rf, anti ccp , anti dna, anti sm,crp, Esr, scl-70 are negative, autoimmune disease?

I have joint pain and sometimes feel fever,twitching. Ana 1:40 but Rf, anti ccp , anti dna, anti sm,crp, Esr, scl-70 are negative, autoimmune disease?

Consultation advised: Unfortunately, Medicine is much too complicated to be able to give helpful advice on the basis of such limited information. An IN BOX Text consultation at Health Tap may be helpful.You would need to upload results of any tests, if available, as well as your medical history. You would NEED TO MAKE YOURSELF AVAILABLE for 24 hours to reply to any questions from your consultant.http://bit.ly/1OiIRcI ...Read more

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Causes of elevated CRP (18.4) and C4 comlement (46)? History: ana, ccp positive. Sjogren's symptoms but ssa/b neg. No arthritis. Fatigued.?

Causes of elevated CRP (18.4) and C4 comlement (46)? History: ana, ccp positive. Sjogren's symptoms but ssa/b neg. No arthritis. Fatigued.?

You have inflammatio: Your tests indicate inflammation. Sjogren's not associated with high inflammation. Ccp positivity fairly specific for ra. Chronic fatigue is common in both RA and sjogrens. And sjogren's (2') common in ra! responds well to Nuvigil or provigil! have you seen a rheumatology specialist to sort things out? ...Read more

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Ana 1:640 only +lab.On meds 4 undiffer connective tissue disease(sx: immense fatigue, jt pain, sicca, photosensitivity).Why other labs all neg & have sx?

Ana 1:640 only +lab.On meds 4 undiffer connective tissue disease(sx: immense fatigue, jt pain, sicca, photosensitivity).Why other labs all neg & have sx?

Surgery?: Depends on what surgery.... Surgery to help with pain is more successful if repairing something that is torn or broken or known to be correctable. ...Read more

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I tested positive for the ANA screen, 1:160 titer, speckled pattern. Rheumatoid factor 21, SED rate 22. Does this indicate Rheumatoid arthritis?

I tested positive for the ANA screen, 1:160 titer, speckled pattern. Rheumatoid factor 21, SED rate 22. Does this indicate Rheumatoid arthritis?

No: The rheumatoid factor was barely above negative. It is usually greater than 150 in RA. The CCP antibody is a much more specific test. The diagnosis of RA depends on several diagnostic criteria. The rheumatoid factor is nonspecific. ...Read more

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Rheumatoid arthiritis, + lupus antibodies, what does this mean?

Rheumatoid arthiritis, + lupus antibodies, what does this mean?

RA and lupus antibod: If the arthritis looks like RA and the RA antibodies are negative , the disease usually is less erosive and less distrctive to joints and can acrue more symptoms and signs of lupus. If the rheumatoid factor or ccp are positive, that makes the disease act more like ra. ...Read more

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Severe widespread joint pain/morning stiffness 9 mnth. Daily 20mg prednisone did not work, MRI of joints show no inflammation. RF DNA SM neg ANA 1:320?

Severe widespread joint pain/morning stiffness 9 mnth. Daily 20mg prednisone did not work, MRI of joints show no inflammation. RF DNA SM neg ANA 1:320?

Alternative: Despite ANA being positive, if you have no inflamm visible & prednisone had no effect, consider an alternative track: many foods cause sensitivities/joint/muscle pain without measurable inflammation.Sugar/Wheat/Gluten are among the most common.Consider seeing a doctor interested in 'Functional Medicine' & they can test for these sensitivities.Other thought: toxicities.These drs can test this, too. ...Read more

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What is this means Anti CCP 319.8 ,CRP -,and RAfactor+ in rheumatoid Arthritis ?

What is this means Anti CCP 319.8 ,CRP -,and RAfactor+ in rheumatoid Arthritis ?

See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, your test results are consistent with rheumatoid arthritis. ...Read more

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Av test positive .Ra factor positive .Joint pain .Ccp antibody test negative.Raised esr.Plz diagnose my disease.

Av test positive .Ra factor positive .Joint pain .Ccp antibody test negative.Raised esr.Plz diagnose my disease.

Cannot diagnose: Although these lab values are interesting, taken out of the context of your symptoms and findings on physical examination, plus further testing there is no way in which to diagnose over the internet. See a rheumatologist and get appropriately assessed. ...Read more

Dr. Robert Lowe
1,559 doctors shared insights

Painful Joints (Definition)

That term is not really a specific diagnosis, but rather somewhat of a general term. The medical term is arthralgias, which implies pain in multiple joint possibly coming from a single cause. Don't hesitate to be seen and evaluated for ...Read more