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Lorton, VA
A 34-year-old male asked:

How effective is iui with clomid for couples with unexplained infertility? my wife and i have been off birth control since july 2010. all of our test results have been normal. i'm extremely frustrated and depressed that we aren't pregnant yet. i'm los

4 doctor answers6 doctors weighed in
Dr. Miguel Cano
Obstetrics and Gynecology 30 years experience
Next step: Congratulations that there hasn't been a test with bad news. With normal ovulation, nl sperm & motility, nl tubes, hormone levels, uterus & cervix - the next step is bypassing the vaginal & cervix environment with iui. Clomid (clomiphene) also makes sense to optimize ovulation & timing of insemination. I know it's frustrating, but trust your doc, don't forget to have fun & love your partner regardless.
Dr. Gerard Honore
Fertility Medicine 29 years experience
Diagnosis?: You are seeing several answers here, that's good. Cc with IUI is often succesful; i won't quote 'rates' because they vary with female age and actual numbers on semen analysis. True unexplained infertility is not common, remember it doesn't mean you 'don't know what's wrong' it means that all tests have been done without a diagnosis. Do you really have unexplained? If not, get a diagnosis.
Dr. Jay Nemiro
Fertility Medicine 45 years experience
Not very: In my experience, clomid-iui is not very effective. Although, couples clearly get pregnant, pregnancy rates are around 8-12% per cycle. At this point, make sure the entire infertility work-up is negative including less common tests- antisperm antibodies, mycoplasma, ca125 to r/o endometriosis. Also, the fda warns only to use Clomid (clomiphene) for 6 cycles in a lifetime.
Dr. Collin Smikle
Obstetrics and Gynecology 36 years experience
Fertility: You didn't mention her age. Still, if you have been trying for 3 years and all the tests have been normal to date, Clomid (clomiphene) and IUI may be helpful but you may want to consider more aggressive treatment if you are planning to have more than 1 child. If she got pregnant now, she may still have challenges in the future and you should consider this when deciding the type of treatment.

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Last updated Oct 3, 2016

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