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Belchertown, MA
A 64-year-old male asked:

i know that divalproex sodium can increase shbg, thereby reducing free testosterone, but does it have any effect on total t in men?

1 doctor answer1 doctor weighed in
Dr. Gregory Lewis
Urology 44 years experience
See answer: You are correct. Most of the anti-epileptic drugs (aeds) increase shbg and reduce free t. Even though aeds may raise total t levels because of this effect on shbg, the total t levels almost always remain within the wide normal range for total t (~300-1100 ng/dl) depending on the reference range used by a given lab. Free t and albumin-bound t (bioavailable t) are the active forms of t in the body.

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Last updated Jan 21, 2014

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