A 2-year-old male asked:
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long term use of children's benadryl (diphenhydramine) vs zyrtec. which one works best with the least chance of becoming tolerant or non responsive ? should i alternate

2 doctor answers
Dr. Sathish Adigopula
19 years experience Pediatrics
.: You could possibly alternate but cetirazine is a better option than Diphenhydramine as there is less sedation. If you are looking for long term medications you could look into local treatment including nasal sprays and eye drops.
Answered on May 19, 2016
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Dr. Ajay Pathak
18 years experience General Practice
Allergy Meds: One should see an allergist to identify the allergens ang get appropriate treatment. Long term use of Benadryl (diphenhydramine) or zurtec specially at young age without physician supervision is harmful.
Answered on Apr 25, 2015
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Yes.: There should not be any significant interaction although both meds are in the same class.
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Dr. Andrew Murphy
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Not really: These are both antihistamines. If both are needed then physician guidance should be sought.

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