A 24-year-old female asked:
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is stopping diphenhydramine for sleep going to cause any rebound insomnia or other symptoms? if so how long to overcome rebound symptoms?

2 doctor answers
Dr. Bennett Werner
44 years experience Cardiology
No : There shouldn't be any rebound from stopping diphenhydramine. The sleeping effects of daily Diphenhydramine tend to wear off if it's taken every day. It never gets to the point of rebounding. But be aware that without the soporific effects, you may possibly have insomnia independently of any medicine withdrawal effect, since that was the original reason you started using it.
Answered on Jun 25, 2014
Dr. Nour Baltagi
30 years experience Pediatrics
Dependance: I am not aware of any dependance related to this drug (antihistamine), but the symptome of insomnia probably needs to be addressed probably with some lifestyle changes and some physical activity during the day to make you feel more tired and desiring to sleep without medications. Hope this is somewhat helpful.
Answered on Jun 14, 2014
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Short term: These otc meds are for short term purposes only. But insomnia should be addressed further if it becomes chronic as there ate many causes to this.
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