A 32-year-old member asked:
does ms involve the hypothalamus?
1 doctor answer
Dr. Bennett Machanic answered
52 years experience Neurology
Yes, it surely can: There is considerable evidence that involvement of the hypothalamic-pituitary-adrenal axis can play a role in fatigue. Many ms patients do develop a variety of sleep disorders and a loss of hypocretin-i-secreting cells may be due to autoimmune mechanisms, perhaps enhancing daytime sleepiness. (seems some overlap with hla-dr-2 typing, as related to both ms and narcolepsy).
Answered on Apr 2, 2020
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