A 25-year-old male asked:
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why is there an increased risk of developing osteomyelitis in sickle cell anaemia patients having salmonella infection only? (pathogenesis)

3 doctor answers
Dr. Grace Torres-hodges
23 years experience Podiatry
Serum deficiency: Sickle cell patients have an abnormal red blood cell shape. Long bones, particularly at the epiphyseal plates in children, are most vulnerable due to the presence of blood vessels. Combine that with a serum deficiency, against salmonella, it increases the risk of osteomyelitis. Reference article - http://www.Ncbi.Nlm.Nih.Gov/pmc/articles/pmc1541118/.
Answered on Aug 25, 2013
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Dr. Bruce J. Stringer
47 years experience Radiology
Not just salmonella: The most common cause of osteomyelitis in patients with sickle cell disease is actually staphylococcus, not salmonella. Sickle patients develop areas of bone infarction which would be generally a setup for any infection.
Answered on Sep 4, 2013
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Dr. Michael Ginsburg
12 years experience Interventional Radiology
Sickle cell disease: Although salmonella frequently cause osteomyelitis in sickle cell dz patients, it isn't the most common cause - the most common cause remains staphylococcus. Sickle cell dz predisposes to infections including osteomyelitis due to: hyposplenism & infarcted bone (due to microvascular occlusion). Salmonella is thought to spread from intestine secondary to microinfarction of bowel caused by sickling.
Answered on Dec 1, 2014
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